Traumatic Brain Injury and Neurovascular Disturbances

Impact Induces Phagocytic Defect in Reactive Microglia

This study uses a TBI-on-a-chip model to show that impact injury reduces microglial phagocytosis and alters lipid metabolism, affecting neuroinflammation and neurodegeneration.

Continuous monitoring of cerebrovascular autoregulation using functional ultrasound imaging in the piglet brain.

This study evaluates functional ultrasound (fUS) for continuous monitoring of cerebrovascular autoregulation in piglets, showing improved stability and reproducibility compared to standard methods.

Cognitive dysfunction following brain trauma results from sex-specific reactivation of the developmental pruning processes

This study identifies a sex-specific reactivation of developmental pruning processes as a cause of cognitive dysfunction after brain trauma and shows the pathway is reversible.

Coordinate-Dependent Neuroinflammation and Metabolic Disruption Following Experimental Traumatic Brain Injury

This study examines how the site of traumatic brain injury affects microglial activation and neuronal damage, revealing coordinate-specific neuroinflammatory and metabolic changes.

Caloric restriction worsens decision-making impairments and gut dysbiosis after brain injury in male rats

Chronic Behavioral and Seizure Outcomes following Experimental Traumatic Brain Injury and Comorbid Klebsiella pneumoniae Lung Infection in Mice

This study investigates the long-term effects of Klebsiella pneumoniae infection following traumatic brain injury in mice, finding no significant impact on neurobehavioral outcomes or seizure development.

NLRP3 inhibition maintains microglia architecture and enhances behavioral recovery after traumatic brain injury

This study investigates the role of NLRP3 inhibition in reducing neuroinflammation and improving behavioral recovery after traumatic brain injury.

ASC contributes to sustained glial reactivity and mild cognitive impairment after closed-head injury

This study shows that ASC sustains neuroinflammation and contributes to cognitive deficits after mild closed-head injury.

Oxytocin release modulates acute neuroinflammation and improves brain development after pediatric traumatic brain injury

This study shows that oxytocin release reduces acute neuroinflammation and improves long-term brain development after pediatric traumatic brain injury in mice.

Release of extracellular matrix components after human traumatic brain injury

This study measures sulfated glycosaminoglycan (sGAG) levels in ventricular CSF, blood, and urine of TBI patients to assess extracellular matrix damage and its correlation with injury characteristics.

Vaccines for immunological defense against traumatic brain injury

This paper develops a vaccine formulation to reduce inflammation after traumatic brain injury by inducing immunosuppressive cells and improving motor function in mice.

Physics-Informed Digital Twin Can Predict Cerebral Blood Flow and Cerebral Vascular Regulation Mechanisms in Neurocritical Care Patients

This paper introduces CereBRLSIM, a digital twin that predicts cerebral blood flow and CVR mechanisms in neurocritical care patients with higher accuracy than machine learning models.

Spreading depolarizations exhaust neuronal ATP in a model of cerebral ischemia

This study measures intracellular neuronal ATP changes during spreading depolarizations in cerebral ischemia models, showing ATP depletion under oxygen and glucose deprivation.

Simulated ischemia in live cerebral slices is mimicked by opening the Na+/K+ pump: clues to the generation of spreading depolarization.

The paper shows that palytoxin mimics ischemia-induced spreading depolarization in brain slices by activating the Na+/K+ pump, suggesting a potential therapeutic target for ischemic brain injury.

Idebenone Enhances the Early Microglial Response to Traumatic Brain Injury and Mitigates Acute Gene Expression Changes to Ephrin-A and Dopamine Signaling Pathways

This study shows idebenone enhances microglial activation after TBI but reduces gene expression changes in dopamine and Ephrin-A signaling pathways.

Intracranial hypertension drives astrocyte-mediated neuroinflammation through Piezo1-dependent EGFR activation

This study identifies a mechanosensitive astrocyte signaling pathway linking intracranial pressure to neuroinflammation via Piezo1-dependent EGFR activation.

Temporal Dynamics of Azot Expression Following Traumatic Brain Injury.

This study examines Azot expression dynamics after traumatic brain injury in Drosophila, showing increased apoptotic elimination of 'loser' cells and expanded cell competition to include both neurons and glia.

Biphasic Changes in Hippocampal Granule Cells after Traumatic Brain Injury

This study examines changes in hippocampal granule cell excitability and synaptic transmission after TBI, finding biphasic alterations in synaptic input patterns over time.

A Pilot Study to Establish a Penetrating Traumatic Brain Injury Rat Model for Implantation of a 3D Printed Scaffold

This study establishes a TBI rat model with BBB disruption and tests the biocompatibility of a PLGA/rGO scaffold, finding mild TBI evidence and no foreign body rejection after 30 days.

AI-assisted In-silico Trial for the Optimization of Osmotherapy following Ischaemic Stroke

This paper develops an AI-assisted in-silico trial to optimize osmotherapy protocols for ischaemic stroke by predicting intracranial pressure and personalizing treatment based on patient-specific data.

Genetic Modifiers Influencing the Acute and Long-Term Responses to Traumatic Brain Injury in Drosophila

This study investigates genetic modifiers of traumatic brain injury responses in Drosophila using a high-throughput trauma model, identifying factors that influence acute and long-term outcomes.

Glutamate uptake is transiently compromised in the perilesional cortex following controlled cortical impact

This study shows that glutamate uptake is temporarily reduced in the perilesional cortex after TBI, contributing to excitotoxicity, but returns to normal levels by 14 days post-injury.

The transcriptional response of cortical neurons to concussion reveals divergent fates after injury

This study examines how cortical neurons respond to mild TBI, identifying ATF3 as a marker for stress-responsive neurons and showing that layer V neurons die while layer II/III neurons survive.

Cisternostomy facilitates clearance of metabolic waste from cerebrospinal fluid in patients with traumatic brain injury

This study identifies metabolites cleared by cisternostomy in TBI patients, showing their correlation with clinical improvement.

Sound-Enhanced Sleep Depth Reduces Traumatic Brain Injury Damage and Sequelae and Supports Microglial Response

A post-injury immune challenge with lipopolysaccharide following adult traumatic brain injury alters neuroinflammation and the gut microbiome acutely, but has little effect on chronic outcomes

This study shows that LPS treatment after TBI causes acute neuroinflammation and gut microbiome changes but does not affect long-term outcomes.

Type 1 lymphocytes accumulate in the thalamus and produce interferon-γ to restrict seizure susceptibility after brain injury

The paper shows type 1 lymphocytes produce interferon-γ in the thalamus after brain injury, reducing seizure susceptibility by limiting neural hyperexcitability.

Minimally invasive serial collection of cerebrospinal fluid reveals sex-dependent differences in neuroinflammation in a rat model of mild traumatic brain injury

This study uses minimally invasive CSF collection in a rat mTBI model to show males have a more robust inflammatory response than females.

Imaging the large-scale and cellular response to focal traumatic brain injury in mouse neocortex

This study uses in vivo calcium imaging to examine neural activity and behavioral changes in mice after focal traumatic brain injury, revealing spatial and temporal adaptations in the cortex.

The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI

This study shows that FGFR inhibition with Rogaratinib reduces microglia reactivity and synaptic loss in TBI by dampening neuroimmunological responses.