Traumatic Brain Injury and Neurovascular Disturbances

Loss of C3 and CD14 reduces region-specific neuroinflammation in a murine polytrauma model

This study shows that loss of C3 and CD14 reduces neuroinflammation in a murine polytrauma model, with differential effects across brain regions.

A 3D Human Neuron-on-Chip Platform to Monitor Neuronal Injury Responses

This study introduces a 3D Neuron-on-Chip platform to study neuronal injury responses in human prefrontal cortex neurons, revealing biphasic injury responses and stage-specific inflammatory signaling.

Rubicon modulates neuroimmune responses following traumatic brain injury

This study shows that Rubicon promotes neuroinflammation and oxidative stress after traumatic brain injury by affecting autophagy and ROS production, and suggests it as a potential therapeutic target.

Neuronal Toll-like Receptor-4 regulation of Matrix Metalloproteinase-9 Activity Mediates Dentate Circuit Dysfunction after Traumatic Brain Injury

This study identifies a TLR4-MMP-9 signaling axis that drives early post-TBI dentate gyrus circuit dysfunction and behavioral deficits in rodents.

GFAP Degradation in TBI: Linking Novel Modified Products to Astrocyte Pathology and Patient Outcome

This study identifies novel GFAP breakdown products and modifications in TBI patients, linking them to astrocyte pathology and clinical outcomes.

Imaging traumatic brain injuries in mice with potassium channel PET tracer 3F4AP

This study evaluates [18F]3F4AP PET imaging for detecting demyelination in traumatic brain injury models in mice, showing increased tracer uptake correlating with histological evidence of myelin loss.

Upregulation of interleukin-1β and interleukin-18 in traumatic brain injury patients and their potential as biomarkers

This study investigates the upregulation of IL-1β and IL-18 in traumatic brain injury patients and assesses their potential as biomarkers.

Telomerase mRNA-Lipid nanoparticles attenuate neuroinflammation after traumatic brain injury in mice

This paper shows that delivering telomerase mRNA via lipid nanoparticles reduces neuroinflammation and oxidative stress after traumatic brain injury in mice.

Temporal and cell-type specific SPAK-NKCC1 disruption following severe TBI in the developing gyrencephalic brain.

This study examines age-dependent changes in NKCC1 and SPAK expression following TBI in piglets, identifying potential therapeutic targets for pediatric TBI.

Mechanical stretch disrupts calcium dynamics and redistributes Piezo1 in human astrocytes

This study uses a 2D stretch injury model to show that mechanical stretch disrupts calcium dynamics, mitochondrial function, and Piezo1 distribution in human astrocytes, with temporary effects at moderate injury severity.

Nrg1 regulates cortical wiring and motor recovery upon traumatic injury

This study shows that Nrg1 is crucial for adult cortical repair after traumatic injury, as its deletion impairs structural connectivity and motor recovery, especially in aged mice.

Controlled Release of Bone Morphogenetic Protein-2 Improves Motor Function After Traumatic Brain Injury in a Rat Model

This study evaluates a hydrogel-based approach for single-stage traumatic brain injury treatment in rats, showing improved motor function and reduced brain atrophy through controlled release of BMP-2.

Basophils activate splenic B cells and Dendritic cells via IL-13 signaling in acute Traumatic Brain Injury

The paper identifies basophil recruitment to the spleen following TBI and shows their activation of B cells and dendritic cells via IL-13 signaling, enhancing protein translation through NORAD.

NPD1/GPR37 axis protects painful traumatic brain injury and its complications

This study shows that NPD1/GPR37 signaling protects against TBI-induced neuropathic pain and its complications by modulating demyelination, glial responses, and neuroinflammation.

Differential DNA Methylation of the Brain-Derived Neurotrophic Factor Gene is Observed after Pediatric Traumatic Brain Injury Compared to Orthopedic Injury

This study finds that BDNF DNA methylation differs between children with traumatic brain injury and orthopedic injury, particularly in the acute phase.

Analysis of markerless limb tracking reveals chronic and progressive motor deficits after a single closed head injury in mice

A spatial gene expression signature of the mouse brain post-injury at the focal point of contusion

This study examines spatial gene expression changes in the mouse brain after focal TBI, identifying region-specific transcriptional responses and the role of immune cells in modulating post-injury gene activity.

The NOX2-ROS-NLRP3 inflammasome axis in traumatic brain injury

This paper investigates the role of NOX2-ROS-NLRP3 inflammasome axis in traumatic brain injury and shows that inhibiting NOX2 with GSK2795039 reduces neuroinflammation and improves neurobehavioral outcomes in mice.

Traumatic Brain Injury Exacerbates Alcohol Consumption and Neuroinflammation with Decline in Cognition and Cholinergic Activity

This study shows that traumatic brain injury increases alcohol consumption and impairs cognition by reducing cholinergic activity and increasing microglial cells in mice.

Fate mapping of peripherally derived macrophages reveals a long-lasting engrafted population that maintains a distinct transcriptomic profile for up to 8 months after Traumatic Brain Injury

This study tracks the fate of monocyte-derived macrophages (MDMs) after traumatic brain injury (TBI) and finds they persist in the brain for up to 8 months, maintaining a distinct transcriptomic profile and phagocytic activity.

A neuroprotective tetrapeptide for treatment of acute traumatic brain injury

This study evaluates the neuroprotective effects of the tetrapeptide CAQK in TBI models, showing reduced injury size, inflammation, and functional deficits.

Cognitive dysfunction following brain trauma results from sex-specific reactivation of the developmental pruning processes

This study identifies a sex-specific reactivation of developmental pruning processes as a cause of cognitive dysfunction after brain trauma and shows the pathway is reversible.

Caloric restriction worsens decision-making impairments and gut dysbiosis after brain injury in male rats

Chronic Behavioral and Seizure Outcomes following Experimental Traumatic Brain Injury and Comorbid Klebsiella pneumoniae Lung Infection in Mice

This study investigates the long-term effects of Klebsiella pneumoniae infection following traumatic brain injury in mice, finding no significant impact on neurobehavioral outcomes or seizure development.

Release of extracellular matrix components after human traumatic brain injury

This study measures sulfated glycosaminoglycan (sGAG) levels in ventricular CSF, blood, and urine of TBI patients to assess extracellular matrix damage and its correlation with injury characteristics.

Vaccines for immunological defense against traumatic brain injury

This paper develops a vaccine formulation to reduce inflammation after traumatic brain injury by inducing immunosuppressive cells and improving motor function in mice.

Spreading depolarizations exhaust neuronal ATP in a model of cerebral ischemia

This study measures intracellular neuronal ATP changes during spreading depolarizations in cerebral ischemia models, showing ATP depletion under oxygen and glucose deprivation.

Simulated ischemia in live cerebral slices is mimicked by opening the Na+/K+ pump: clues to the generation of spreading depolarization.

The paper shows that palytoxin mimics ischemia-induced spreading depolarization in brain slices by activating the Na+/K+ pump, suggesting a potential therapeutic target for ischemic brain injury.

Biphasic Changes in Hippocampal Granule Cells after Traumatic Brain Injury

This study examines changes in hippocampal granule cell excitability and synaptic transmission after TBI, finding biphasic alterations in synaptic input patterns over time.

AI-assisted In-silico Trial for the Optimization of Osmotherapy following Ischaemic Stroke

This paper develops an AI-assisted in-silico trial to optimize osmotherapy protocols for ischaemic stroke by predicting intracranial pressure and personalizing treatment based on patient-specific data.