Traumatic Brain Injury and Neurovascular Disturbances

THERAPEUTIC EFFECTS OF AN INSULIN-LIKE GROWTH FACTOR I SENSITIZER IN TRAUMATIC BRAIN INJURY

This study shows that AIK3, an IGF-1 sensitizer, improves sensorimotor, neurological, and cognitive functions in mice with mild TBI.

Rapid Intracellular Delivery of Human Heat Shock Protein 72 Inhibits Neurodegeneration and Oxidative Damage After a Traumatic Brain Injury

This study shows Fv-HSP72 reduces neurodegeneration and oxidative stress in rats with traumatic brain injury.

Towards Identifying a Molecular Activator of Spreading Depolarization Generated by the Ischemic Brain

This study identifies a compound released by ischemic brain tissue that promotes spreading depolarization and shows it synergizes with NKA inhibition to cause RBC hemolysis.

Intranasal CRISPR- lipid nanoparticles targeting MAPK9 reduce neuroinflammation after traumatic brain injury

This paper develops an intranasal CRISPR-based therapy targeting MAPK9 in microglia to reduce neuroinflammation after traumatic brain injury, showing reduced inflammation and no toxicity.

GFAP Degradation in TBI: Linking Novel Modified Products to Astrocyte Pathology and Patient Outcome

This study identifies novel GFAP breakdown products and modifications in TBI patients, linking them to astrocyte pathology and clinical outcomes.

Imaging traumatic brain injuries in mice with potassium channel PET tracer 3F4AP

This study evaluates [18F]3F4AP PET imaging for detecting demyelination in traumatic brain injury models in mice, showing increased tracer uptake correlating with histological evidence of myelin loss.

Upregulation of interleukin-1β and interleukin-18 in traumatic brain injury patients and their potential as biomarkers

This study investigates the upregulation of IL-1β and IL-18 in traumatic brain injury patients and assesses their potential as biomarkers.

Telomerase mRNA-Lipid nanoparticles attenuate neuroinflammation after traumatic brain injury in mice

This paper shows that delivering telomerase mRNA via lipid nanoparticles reduces neuroinflammation and oxidative stress after traumatic brain injury in mice.

Impact of innate immune activation on T cell dynamics and functional recovery following traumatic brain injury

This study investigates how innate immune activation, particularly IL-1β, affects T cell dynamics and functional recovery after traumatic brain injury in mice.

Therapeutic Targeting of Microglial Hexokinase-2 Recalibrates Inflammasome Activation and Improves Functional Recovery After Traumatic Brain Injury

Temporal and cell-type specific SPAK-NKCC1 disruption following severe TBI in the developing gyrencephalic brain.

This study examines age-dependent changes in NKCC1 and SPAK expression following TBI in piglets, identifying potential therapeutic targets for pediatric TBI.

Increased CD3 Immunoreactive Cells Persist Chronically in the Brain Parenchyma in Association with Focal Cortical Contusion following Experimental TBI

This study shows that T-cell infiltration persists chronically in the brain after focal cortical contusion in swine, but not with inertial injury, suggesting an adaptive immune response to TBI.

PRECISE TBI Model Catalog: Increasing Accessibility and Reproducibility in TBI research

The paper introduces a centralized catalog of preclinical TBI models to improve reproducibility and accessibility by consolidating metadata from published studies.

Differential sex-dependent responses of circulating steroid hormones and cortical gene expression in a preclinical traumatic brain injury model

This study examines sex-dependent changes in circulating steroid hormones and cortical gene expression following traumatic brain injury in mice, revealing sex-specific alterations in hormone levels and gene expression related to immune and tissue responses.

Mechanical stretch disrupts calcium dynamics and redistributes Piezo1 in human astrocytes

This study uses a 2D stretch injury model to show that mechanical stretch disrupts calcium dynamics, mitochondrial function, and Piezo1 distribution in human astrocytes, with temporary effects at moderate injury severity.

Nrg1 regulates cortical wiring and motor recovery upon traumatic injury

This study shows that Nrg1 is crucial for adult cortical repair after traumatic injury, as its deletion impairs structural connectivity and motor recovery, especially in aged mice.

Improved myelin clearance and cognitive outcomes after TBI in female mice are mediated by ovarian steroids and sex chromosomes

This study shows that ovarian steroids and sex chromosomes influence myelin clearance and cognitive outcomes after TBI in female mice through astrocyte-mediated mechanisms.

Repeated Mild Head Injury Establishes a Senescent Cranial Bone Marrow Niche that Impairs Brain Metabolism

This study shows that repeated mild head injury leads to senescence in cranial bone marrow, impairing brain metabolism and causing systemic inflammation.

Controlled Release of Bone Morphogenetic Protein-2 Improves Motor Function After Traumatic Brain Injury in a Rat Model

This study evaluates a hydrogel-based approach for single-stage traumatic brain injury treatment in rats, showing improved motor function and reduced brain atrophy through controlled release of BMP-2.

Basophils activate splenic B cells and Dendritic cells via IL-13 signaling in acute Traumatic Brain Injury

The paper identifies basophil recruitment to the spleen following TBI and shows their activation of B cells and dendritic cells via IL-13 signaling, enhancing protein translation through NORAD.

NPD1/GPR37 axis protects painful traumatic brain injury and its complications

This study shows that NPD1/GPR37 signaling protects against TBI-induced neuropathic pain and its complications by modulating demyelination, glial responses, and neuroinflammation.

Differential DNA Methylation of the Brain-Derived Neurotrophic Factor Gene is Observed after Pediatric Traumatic Brain Injury Compared to Orthopedic Injury

This study finds that BDNF DNA methylation differs between children with traumatic brain injury and orthopedic injury, particularly in the acute phase.

Analysis of markerless limb tracking reveals chronic and progressive motor deficits after a single closed head injury in mice

A spatial gene expression signature of the mouse brain post-injury at the focal point of contusion

This study examines spatial gene expression changes in the mouse brain after focal TBI, identifying region-specific transcriptional responses and the role of immune cells in modulating post-injury gene activity.

The NOX2-ROS-NLRP3 inflammasome axis in traumatic brain injury

This paper investigates the role of NOX2-ROS-NLRP3 inflammasome axis in traumatic brain injury and shows that inhibiting NOX2 with GSK2795039 reduces neuroinflammation and improves neurobehavioral outcomes in mice.

Traumatic Brain Injury Exacerbates Alcohol Consumption and Neuroinflammation with Decline in Cognition and Cholinergic Activity

This study shows that traumatic brain injury increases alcohol consumption and impairs cognition by reducing cholinergic activity and increasing microglial cells in mice.

Fate mapping of peripherally derived macrophages reveals a long-lasting engrafted population that maintains a distinct transcriptomic profile for up to 8 months after Traumatic Brain Injury

This study tracks the fate of monocyte-derived macrophages (MDMs) after traumatic brain injury (TBI) and finds they persist in the brain for up to 8 months, maintaining a distinct transcriptomic profile and phagocytic activity.

Delayed protective effect of chronic variable stress on optic tract axonal degeneration after experimental TBI

This study shows that chronic variable stress after TBI initially worsens axonal degeneration but later provides a delayed protective effect, possibly through changes in microglial and astrocytic phagocytic activity.

A neuroprotective tetrapeptide for treatment of acute traumatic brain injury

This study evaluates the neuroprotective effects of the tetrapeptide CAQK in TBI models, showing reduced injury size, inflammation, and functional deficits.

Evidence for the Transient Presence of Atypical Astrocytes in Mice Following a Single, Closed-Head Mild Traumatic Brain Injury

This study shows that a single closed-head mild traumatic brain injury (mTBI) in mice temporarily increases atypical astrocytes (AtAs) but they do not persist long-term, unlike in repeated mTBI.