Traumatic Brain Injury and Neurovascular Disturbances

Severe traumatic brain injury temporally affects cerebral blood flow, endothelial cell phenotype, and cilia

This study shows that severe traumatic brain injury disrupts cerebral blood flow and leads to loss of ciliary protein ARL13B in endothelial cells.

A Pvr-AP-1-Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury

The paper identifies a Pvr-AP-1-Mmp1 signaling pathway activated in astrocytes after traumatic brain injury and shows endocytosis regulates its activity.

antiCD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8 T cell cytotoxicity after traumatic brain injury

This study shows that anti-CD49d antibody treatment reduces age-related inflammatory responses and CD8 T cell cytotoxicity after traumatic brain injury in mice.

Identification of key genes and enriched biological processes in diabetes-associated traumatic brain injury through weighted gene correlation network and bioinformatics analysis

High-dimensional proteomic analysis for pathophysiological classification of Traumatic Brain Injury

This study uses high-dimensional proteomic analysis to identify TBI-specific plasma protein changes linked to injury patterns and pathophysiology in humans.

Vascular responses of hypercapnia challenge in mice

This study examines vascular responses to hypercapnia in mice, showing that 5 minutes of 5% CO2 is sufficient for 95% CBF increase but recovery takes longer than the built-up phase.

Early hippocampal high-amplitude rhythmic spikes predict post-traumatic epilepsy in mice

The paper identifies early high-amplitude rhythmic spikes in the hippocampus of mice after traumatic brain injury as predictive of post-traumatic epilepsy.

Return of intracranial beta oscillations and traveling waves with recovery from traumatic brain injury

This study identifies beta oscillations and traveling waves as biomarkers of recovery from traumatic brain injury using intracranial electrode data.

The Surgical Method of Craniectomy Differentially Affects Acute Seizures, Brain Deformation and Behavior in a TBI Animal Model

This study compares the effects of hand and electric drilling craniectomy on TBI in rats, finding that electric drilling causes more tissue damage and seizures.

Loss of AMPK potentiates inflammation by activating the inflammasome after traumatic brain injury in mice.

This study shows that loss of AMPK after traumatic brain injury in mice worsens inflammation and behavioral outcomes by increasing inflammasome activation and proinflammatory cytokines.

Skull bone marrow-derived immune cells infiltrate the damaged cortex and exhibit anti-inflammatory properties

This study shows skull bone marrow-derived immune cells infiltrate the injured brain, exhibit anti-inflammatory properties, and differ from blood-derived macrophages in their phenotype and distribution.

Cortical inhibitory parvalbumin interneurons exhibit metabolic specializations coordinated by PGC-1α that are lost in rodents and humans after traumatic brain injury

The paper shows that PV-INs have unique metabolic specializations lost after TBI, which can be rescued by 2-deoxyglucose, and identifies PGC-1α and lncRNAs as key factors in this dysfunction.

A larval zebrafish model of TBI: Optimizing the dose of neurotrauma for discovery of treatments and aetiology

This paper develops a larval zebrafish model of TBI to optimize injury severity for studying treatment and aetiology, observing correlations between injury levels and clinical phenotypes like seizures and tau aggregation.

Cerebral hypoperfusion exacerbates traumatic brain injury in male but not female mice.

This study shows that cerebral hypoperfusion worsens traumatic brain injury outcomes in male mice but not female mice, with distinct gene expression changes observed in males.

Blast Traumatic Brain Injury Induces Long-Term Alterations in Inflammatory Gene Expression in Chinchilla Brains

This study examines long-term inflammatory gene expression changes in chinchilla brains after blast traumatic brain injury, finding prolonged neuroinflammation in multiple brain regions even after mild exposure.

Histological comparison of repeated mild weight drop and lateral fluid percussion injury models of traumatic brain injury (TBI) in female and male rats.

This paper compares two TBI models in rats, finding that lateral fluid percussion causes more severe and lasting disruptions than repeat mild weight drop.

Brief Apnea and Hypoventilation Reduces Seizure Duration and Shifts Seizure Location for Several Hours in a Model of Severe Traumatic Brain Injury.

The paper investigates how brief apnea and hypoventilation (A&H) after seizures in a severe TBI model reduces seizure duration and shifts seizure location for several hours.

IDO-1 inhibition improves outcome after fluid percussion injury in adult male rats

This study shows that inhibiting IDO1 reduces KP activity and improves memory and anxiety-like behaviors in rats after fluid percussion injury.

Shared inflammatory glial cell signature after brain injury, revealed by spatial, temporal and cell-type-specific profiling of the murine cerebral cortex

The paper identifies a shared inflammatory glial cell signature after brain injury using spatial and single-cell transcriptomics in mice, showing common injury-regulated genes across astrocytes, microglia, and oligodendrocyte precursor cells.

A model of traumatic brain injury using human iPSC-derived cortical brain organoids

This study uses high-intensity focused ultrasound to induce traumatic brain injury in human iPSC-derived cortical organoids, revealing key pathological features like tau phosphorylation and neurodegeneration.

Probiotic treatment causes sex-specific neuroprotection after traumatic brain injury in mice

This study shows that probiotic treatment reduces TBI severity and behavioral deficits in male mice but not female mice.

Acute and Chronic Neural and Glial Response to Mild Traumatic Brain Injury in the Hippocampus

This study uses a novel ex vivo model to investigate acute and chronic neural responses to mild traumatic brain injury in the hippocampus, linking injury forces to cellular and functional changes.

Delayed cerebrovascular dysfunction and social deficits after traumatic brain injury

This study shows that traumatic brain injury leads to delayed cerebrovascular dysfunction and social deficits in mice, with reduced cerebral blood flow and vascular density linked to impaired social behavior.

Sex-dependent improvement in traumatic brain injury outcomes after liposomal delivery of dexamethasone in mice.

This study shows that liposomal dexamethasone reduces TBI lesion volume and inflammation in male mice but not females.

Model matters: Differential outcomes in traumatic optic neuropathy pathophysiology between blunt and blast-wave mediated head injuries.

This study compares blunt and blast-wave mediated head injuries in mice, finding distinct visual system injury patterns and histological outcomes.

Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

This study shows that traumatic brain injury disrupts functional connectivity in mice, with recovery and state-dependent changes in connectivity and theta power during stillness.

Optimization of a Translational Murine Model of Closed-head Traumatic Brain Injury

This study optimizes a murine closed-head TBI model by reducing variability across injury severity and sex, improving translational relevance.

Synaptic Zn2+ contributes to deleterious consequences of spreading depolarizations

This study investigates the role of synaptic Zn2+ release in spreading depolarizations and shows that pharmacological chelation can improve recovery in vulnerable conditions.

Sleep Disruption in a Mouse Model of Chronic Traumatic Brain Injury

This study develops a chronic TBI mouse model and finds that TBI leads to lifelong sleep/wake disturbances, circadian disruptions, and neuropathology.

Translating from mice to humans: using preclinical blood-based biomarkers for the prognosis and treatment of traumatic brain injury

This study reviews preclinical blood biomarkers for traumatic brain injury, finding that NfL and GFAP show promise for prognosis and pharmacodynamic studies.