Traumatic Brain Injury and Neurovascular Disturbances

Neuroprotective Effects of Naltrexone in a Mouse Model of Post-Traumatic Epilepsy

This study shows that naltrexone prevents neuroinflammation and epileptogenesis in a mouse model of post-traumatic epilepsy.

WGCNA and Machine Learning for Screening Potential Biomarkers in traumatic brain injury

This study identifies potential biomarkers for traumatic brain injury using WGCNA and machine learning, finding seven hub genes with diagnostic value.

Neurons protect themselves by active shrinkage upon axonal transection

The paper shows that axotomy triggers neuronal shrinkage to expel water and prevent swelling, reducing cell death risk.

Mitochondrial dysfunction underlies impaired neurovascular coupling following traumatic brain injury

This study investigates how cortical spreading depolarization (CSD) after traumatic brain injury (TBI) leads to mitochondrial dysfunction, vascular changes, and neurobehavioral deficits in rats.

Noninvasive, automated and reliable detection of spreading depolarizations in severe traumatic brain injury using scalp EEG

This paper introduces an automated algorithm for noninvasive detection of spreading depolarizations in severe TBI patients using scalp EEG, achieving 74% true positive rate with low false positive rate.

Selective neuroimmune modulation by type I interferon drives neuropathology and neurologic dysfunction following traumatic brain injury

This study shows that type I interferon signaling worsens neuropathology and neurologic dysfunction after traumatic brain injury by modulating neuroimmune responses.

Neuronal Tau Pathology Worsens Late Phase White Matter Degeneration After Traumatic Brain Injury in Transgenic Mice

Actomyosin-II Proactively Shields Axons of the Central Nervous System from Mild Mechanical Stress

The paper identifies actomyosin-II-driven radial contractility as a mechanism protecting central axons from mild mechanical stress and shows its protective role in a traumatic brain injury model.

Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue model.

This study investigates mitochondrial dysregulation's role in neurodegeneration after contusion injury using a 3D in vitro triculture model of human brain cells.

Fruit flies subjected to TBI exhibit genotype-dependent changes in seizure incidence and duration

This study develops a fruit fly model of post-traumatic seizures (PTS) and finds that seizure incidence and duration vary with genetic background and time post-injury.

Brief oxygen exposure after traumatic brain injury speeds recovery and promotes adaptive chronic endoplasmic reticulum stress responses.

This study shows that brief oxygen exposure after traumatic brain injury in adolescents reduces mortality, improves visual function, and alters endoplasmic reticulum stress responses.

Leveraging the power of 3D brain-wide imaging and mapping tools for brain injury research in murine models

The paper describes a whole-brain imaging pipeline to study neuronal activity changes after traumatic brain injury in mice, finding reduced c-Fos cell density in injured brains.

Stem cell factor and granulocyte colony-stimulating factor promote remyelination in the chronic phase of severe traumatic brain injury

This study shows that SCF+G-CSF treatment enhances remyelination in the chronic phase of severe TBI by promoting oligodendrocyte progenitor cell proliferation.

Aging with TBI vs. Aging: 6-month temporal profiles for neuropathology and astrocyte activation converge in behaviorally relevant thalamocortical circuitry of male and female rats

This study examines the temporal profiles of neuropathology and astrocyte activation in male and female rats after TBI, showing region-specific and sex-related changes in brain regions involved in somatosensation.

Traumatic brain injury induced microglial and Caspase3 activation in the retina

This study compares the effects of severe and repetitive mild traumatic brain injury on retinal microglial activation and Caspase3-positive cells, highlighting differences in retinal layer responses.

The meningeal transcriptional response to traumatic brain injury and aging

This study investigates the meningeal transcriptional response to traumatic brain injury and aging using scRNA-seq and bulk RNA-seq in mice, revealing age-related differences in immune and extracellular matrix gene expression.

Temporal changes in the microglial proteome of male and female mice after a diffuse brain injury using label-free quantitative proteomics

This study uses label-free proteomics to examine temporal changes in microglial protein expression in male and female mice after TBI, finding sex differences in baseline proteomes but not in response over time.

Met/HGFR triggers detrimental reactive microglia in TBI

This study identifies cMet/HGFR as a modulator of early neuroinflammation in TBI, showing that its inhibition reduces microglial reactivity and improves recovery.

Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

This study shows that reducing neuronal nuclear calcium signaling after TBI increases microglial reactivity and synaptic loss, mediated by osteoprotegerin.

Thyroid Hormone T4 Mitigates Traumatic Brain Injury by Dynamically Remodeling Cell Type Specific Genes, Pathways, and Networks in Hippocampus and Frontal Cortex

This study shows T4 treatment alters cell-type specific genes, pathways, and networks in hippocampus and frontal cortex after mTBI, reversing mTBI-affected genes and pathways.

Unraveling axonal mechanisms of traumatic brain injury

This study investigates axonal swellings (AS) formation after traumatic brain injury, showing that AS occur independently of Ca2+ changes and involve cytoskeletal rearrangements that preserve axonal function.

Single-cell transcriptomics of resected human traumatic brain injury tissues reveals acute activation of endogenous retroviruses in oligodendroglia

The paper uses snRNA-seq to analyze TBI brain tissue, finding oligodendroglia activate endogenous retroviruses, linking them to neuroinflammation.

Longitudinal in vivo monitoring of axonal integrity after brain injury

This study develops an in vivo method to monitor axonal activity over time in mice and shows that P7C3-A20 reduces but does not eliminate axonal dysfunction after brain injury.

Characterization and Preclinical Treatment of Rotational Force-Induced Brain Injury

This study develops a rodent model of rotational head trauma, identifies Cdk5 as a key mediator, and shows its inhibition reduces cognitive and pathological effects.

Brain injury environment critically influences the connectivity of transplanted neurons

This study shows that transplanted neurons in traumatic brain injury environments form excessive but vulnerable connections, while fewer connections are formed in intact or inflamed brains.

Bumetanide increases microglia-interneuron contact following traumatic brain injury

This study shows that bumetanide treatment after traumatic brain injury increases microglia-interneuron contact and improves cognitive function by altering microglial activation and BDNF expression.

Selective Inhibitory Circuit Dysfunction after Chronic Frontal Lobe Contusion

This study identifies selective dysfunction in inhibitory circuits in the orbitofrontal cortex after TBI, linking it to cognitive inflexibility.

Comparing Imaging Biomarkers of Cerebral Edema after TBI in Young Adult Male and Female Rats

The paper compares MRI biomarkers of cerebral edema in male and female rats after TBI, finding sex differences in correlations between imaging metrics and brain water content.

Acute Axon Damage and Demyelination are Mitigated by 4-Aminopyridine (4-AP) Therapy after Experimental Traumatic Brain Injury

This study tests 4-aminopyridine as an acute treatment for traumatic brain injury, finding it reduces axon damage and demyelination in preclinical models.

Concussive head trauma perturbs axon initial segment function in axotomized and intact layer 5 pyramidal neurons

This study examines how concussive head trauma affects axon initial segment function in layer 5 pyramidal neurons, revealing functional disruptions and potential mitochondrial involvement.