Lymphatic System and Diseases

TRPV4-Expressing Tissue-Resident Macrophages Regulate the Function of Collecting Lymphatic Vessels via Thromboxane A2 Receptors in Lymphatic Muscle Cells

This study identifies TRPV4-expressing macrophages as regulators of lymphatic vessel function through TXA2 receptors, suggesting therapeutic targets for lymphedema.

Fibroblasts dynamically regulate lymphatic barrier function by modulating cell-cell junctions

This study shows fibroblasts regulate lymphatic barrier function by modulating junctions and cytoskeletal structure, with tissue-specific effects on endothelial behavior.

Engineered human lymph node stroma model for examining interstitial fluid flow and T cell egress

This study develops an engineered human lymph node stroma model to examine how interstitial fluid flow affects T cell egress and stromal cell behavior.

Lymphatic activation of ACKR3 signaling regulates lymphatic response after ischemic heart injury.

This study identifies ACKR3 signaling in cardiac lymphatics as critical for lymphangiogenesis, edema protection, and survival after ischemic heart injury.

Using lightsheet microscopy to investigate the initial lymphatic network in the murine knee joints

This paper uses lightsheet microscopy to study the lymphatic network in mouse knee joints, finding that post-traumatic OA leads to shorter, smaller branches with more total branching points.

Insulin regulates lymphatic endothelial function via palmitoylation

This study investigates how insulin regulates lymphatic endothelial function through palmitoylation, identifying CD36 as a mediator of this process.

Aquaporin-1 sustains lymphangiogenic responses in inflammatory microenvironments

The paper identifies Aqp1 as critical for lacteal maintenance and inflammatory lymphatic remodelling through single-cell RNA-sequencing and genetic studies in mice.

Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer

This paper develops a technique for intravital imaging of pulmonary lymphatics in mice, revealing ventilation-dependent and -independent lymph flow and leukocyte migration during inflammation and cancer metastasis.

Single-nuclear transcriptomics of lymphedema-associated adipose reveals a pro-lymphangiogenic stromal cell population

The paper uses single-nuclear RNA sequencing to analyze adipose tissue in lymphedema patients, identifying a stromal cell population that promotes lymphangiogenesis.

A Multiresolution Approach with Method-Informed Statistical Analysis for Quantifying Lymphatic Pumping Dynamics

This paper develops a multiresolution imaging and analysis approach to quantify lymphatic pumping dynamics, improving measurement reliability across species and conditions.

IFT20 regulates lymphatic endothelial cell-cell junctions via endocytic trafficking of VE-cadherin

This study shows that IFT20 regulates VE-cadherin localization at lymphatic endothelial cell junctions, affecting lymphangiogenesis and lymph drainage.

S1PR1 Regulates Lymphatic Valve Development And Prevents Ileitis-Independent Tertiary Lymphoid Organ Formation

This study shows that S1PR1 regulates lymphatic valve development and prevents tertiary lymphoid organ formation in the terminal ileum, suggesting TLOs as a sign of subclinical inflammation.

Lymphatic dynamics visualized by native transient hypoxia imaging in areas of tissue damage, edema and in sentinel lymph nodes.

This paper visualizes lymphatic dynamics using transient hypoxia imaging in mice, showing hypoxia in lymph nodes and altered pumping frequency with tissue damage.

Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation

This study identifies mesenchymal Osr1+ cells as regulators of embryonic lymphatic vessel formation by controlling LEC proliferation and migration.

Comparative effects of proton and photon irradiation on the molecular and cellular profiles of triple-negative breast cancer: the crucial impact of VEGFC on tumor microenvironment remodeling

This study compares the effects of proton and photon irradiation on TNBC tumor microenvironment, finding that X-irradiated tumors are more aggressive and VEGFC inhibition reduces proliferation.

Transcriptional, developmental, and functional parallels of lymphatic and venous smooth muscle

This study compares the transcriptomic and developmental origins of lymphatic and venous smooth muscle cells in mice, finding they share similarities but distinct lineage origins.

Ventricular lymphatic vessel density correlates with mild cardiac remodelling and preserved heart function in moderate murine aortic valve stenosis

This study examines the relationship between ventricular lymphatic vessel density, cardiac remodelling, and heart function in a mouse model of moderate aortic valve stenosis.

Calcitonin gene-related peptide and intermedin induce phosphorylation of p44/42 MAPK in primary human lymphatic endothelial cells in vitro

This study shows CGRP and AM2/IMD induce p44/42 MAPK phosphorylation in primary human dermal lymphatic endothelial cells, with CGRP having a sustained effect.

Tissue Regeneration Requires Edema Fluid Clearance by Compensatory Lymphangiogenesis in Zebrafish

This study shows that lymphangiogenesis is crucial for tissue regeneration and edema clearance in zebrafish, revealing key genes and mechanisms involved in this process.

Angpt1 binding to Tie1 regulates the signaling required for lymphatic vessel development in zebrafish

The paper identifies Angpt1/Tie1 signaling as essential for trunk lymphatic vessel development in zebrafish, showing Tie1 regulates Foxo1 localization and modulates Vegfc/Vegfr3 signaling.

Zmiz1 is a novel regulator of lymphatic endothelial cell gene expression and function

This study identifies Zmiz1 as a regulator of lymphatic endothelial cell function and Prox1 expression, showing its role in lymphatic vessel development and valve formation.

Multiple cis-regulatory elements control prox1a expression in distinct lymphatic vascular beds

This study identifies multiple cis-regulatory elements controlling prox1a expression in distinct lymphatic vascular beds in zebrafish.

The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafish

This study identifies Sorbs1's role in zebrafish lymphatic and venous vessel development, showing it regulates cytoskeleton dynamics and BMP signaling, distinct from Vegfc pathways.

An EPHB4-RASA1 signaling complex inhibits shear stress-induced Ras-MAPK activation in lymphatic endothelial cells to promote the development of lymphatic vessel valves

Single nuclei multiomic analyses identify human cardiac lymphatic endothelial cells associated with coronary arteries in the epicardium

The paper identifies a novel population of cardiac lymphatic endothelial cells in human fetal hearts associated with coronary arteries using single nuclei multiomic analysis.

Lymphatic vessel development in human embryos

This study examines human lymphatic vessel development in embryos and fetuses, finding Prox1-expressing LECs originate from cardinal veins and showing organ-specific developmental patterns.

Specialized mesenteric lymphatic capillaries by-pass the mesenteric lymph node chain to transport peritoneal antigens directly into mediastinal lymph nodes.

The paper identifies a specialized mesenteric lymphatic capillary network that bypasses mesenteric lymph nodes to directly transport peritoneal antigens into mediastinal lymph nodes.

Rictor induces AKT signaling to regulate lymphatic valve formation

This study shows that Rictor is essential for AKT signaling in lymphatic valve formation, as its deletion reduces valve numbers and impairs valve maturation.

VEGF-C promotes brain-derived fluid drainage, confers neuroprotection, and improves stroke outcomes

This study shows that VEGF-C overexpression enhances brain fluid drainage, provides neuroprotection, and improves stroke outcomes in mice.

Three-dimensional imaging of vascular development in the mouse epididymis: a prerequisite to better understand the post-testicular immune context of spermatozoa

The paper uses 3D imaging to study the vascular development of the mouse epididymis, revealing the organization of blood and lymphatic networks during development.