Hippo pathway signaling and YAP/TAZ

Inhibition of Yes-Associated Protein (YAP) with Verteporfin Enhances Radiosensitivity in Chordoma by Inducing G2M Arrest and Inhibiting the DNA Damage Response

This study shows that YAP inhibition with verteporfin increases radiosensitivity in chordoma by blocking DNA repair and causing G2M arrest.

Spatiotemporally restricted Hippo signalings instruct the fate and maturation of hepatobiliary cells

This study identifies two Hippo signaling modules, HPO1 and HPO2, that regulate hepatocyte and cholangiocyte maturation at distinct developmental stages and spatial contexts in mouse livers.

Blastocoel expansion and AMOT degradation cooperatively promote YAP nuclear localization during epiblast formation

The paper identifies two mechanisms that promote YAP nuclear localization during epiblast formation: blastocoel expansion increasing F-actin and reducing YAP phosphorylation, and SOX2-mediated AMOT degradation.

A ZO-2 scaffolding mechanism regulates the Hippo signalling pathway.

This study identifies ZO-2 as a scaffolding protein that regulates Hippo signaling by facilitating LATS1-mediated phosphorylation and inactivation of YAP.

IGF2 mediates Hippo signaling to control liver size

This study identifies IGF2 as a mediator of Hippo signaling in liver size control, showing its role in promoting liver growth and hepatoblastoma through IGF1R activation.

Human Satellite 3 DNA encodes megabase-scale transcription factor binding platforms

The paper identifies HSat3 DNA as a platform for transcription factor binding, showing it enhances nucleolar RNA Polymerase I activity through Hippo pathway interactions.

Yap is a Nutrient Sensor Sensitive to the Amino Acid L-Isoleucine and Regulates Expression of Ctgf in Cardiomyocytes.

The paper shows Yap signaling in cardiomyocytes is sensitive to L-isoleucine and regulates Ctgf expression, influencing myocardial adaptation after injury.

An improved TEAD dominant-negative protein inhibitor to study Hippo YAP1/TAZ-dependent transcription.

This study improves a dominant-negative TEAD inhibitor, TEADi, by modifying its binding domains to enhance its ability to block YAP1 and TAZ interactions with TEAD, revealing differences in their displacement mechanisms.

Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling

This study shows that YAP activation in monolayer cultures causes resistance to EGFR/KRAS/BRAF pathway inhibitors, while spheroids are more sensitive, highlighting differences in culture systems for modeling cancer progression.

YAP/TAZ signaling in allantois-derived cells is required for placental vascularization

This study shows that YAP/TAZ signaling in allantois-derived cells is essential for placental vascularization, as its loss causes embryonic lethality and vascular defects.

Dachsous and Fat coordinately repress the Dachs-Dlish-Approximated complex to control growth

This study investigates how Dachsous and Fat regulate the core complex to control growth in Drosophila by modulating its stability and localization.

A nanobody-based approach to capture and visualize specific interactions of binary protein complexes in living cells

The paper introduces a nanobody-based method to capture and visualize binary protein complex interactions in living cells, identifying new regulators of TAZ activity.

Paradoxical Tumor Suppressor Role of Yorkie Through a TOR-Dependent α-Tubulin Acetylation in Select Squamous Epithelium

The paper shows that Yorkie acts as a tumor suppressor in Drosophila squamous epithelia by suppressing TOR-driven α-tubulin acetylation, which is tissue-specific and distinct from other epithelial lineages.

A role for YAP-mediated regulation of invadopodia in HNSCC cells

This study shows that YAP nuclear translocation in HNSCC cells increases with ECM rigidity, promoting ROCK2 expression and invadopodia maturation, which enhances ECM degradation.

VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent tumorigenesis by engaging p300

This study identifies VGLL2 and TEAD1 fusion proteins as YAP/TAZ-independent drivers of tumorigenesis by recruiting p300 for epigenetic regulation.

Crk mediates Csk-Hippo signaling independently of Yap tyrosine phosphorylation to induce cell extrusion

The JNK and Hippo pathways control epithelial integrity and prevent tumour initiation by regulating an overlapping transcriptome

The paper identifies how JNK and Hippo pathways regulate epithelial integrity by controlling an overlapping transcriptome, preventing tumour initiation through shared gene repression.

Hippo pathway-mediated YAP1/TAZ inhibition is essential for proper pancreatic endocrine specification and differentiation

This study shows that Hippo pathway-mediated YAP1/TAZ inhibition is essential for pancreatic endocrine specification and differentiation, but not for beta-cell function.

Hippo-YAP1/TAZ-TEAD signaling coordinates myoblast fusion and sarcomere assembly in skeletal muscle development

This study shows Hippo-YAP1/TAZ-TEAD signaling coordinates myoblast fusion and sarcomere assembly in skeletal muscle development through transcriptional regulation.

YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes

This study shows that YAP overactivation in HCM mutant cardiomyocytes drives hypertrophy via CCN2 secretion and TGFβ uptake.

The Hippo-YAP/TAZ-TEAD axis promotes multipotency in bone marrow stromal cells

This study identifies the Hippo-YAP/TAZ-TEAD axis as a regulator of bone marrow stromal cell multipotency through computational analysis of single-nucleus multiomics data.

The Ccm3-GckIII signaling axis regulates Rab11-dependent recycling to the apical compartment

This paper characterizes a Hippo-like kinase cascade in Drosophila involving Ccm3, GckIII, and Trc, showing their role in tracheal tube morphogenesis and Rab11-dependent recycling.

YAP and TAZ differentially regulate postnatal cortical progenitor proliferation and astrocyte differentiation

This study shows TAZ and YAP have distinct roles in regulating astrocyte differentiation and NPC proliferation through different signaling pathways.

Dynamic Hippo pathway activity underlies mesenchymal differentiation during lung alveolar morphogenesis

The paper identifies dynamic Hippo pathway activity in secondary crest myofibroblasts during lung alveolar development and shows its role in regulating lineage commitment and mesenchymal differentiation.

An Assumption of The Regulatory Function of Nf2-Amot Complex in Early Mammalian Embryos with A Computational Model

The paper develops a computational model to test the regulatory role of the Nf2-Amot complex in early mammalian embryo differentiation, confirming its impact through in silico simulations.

Neuroprotective role of Hippo signaling by microtubule stability control in C. elegans

This study shows that the Hippo pathway maintains neuronal structure by controlling microtubule stability in C. elegans, with implications for delaying neurodegeneration.

Connecting Hippo pathway and cytoophidia in Drosophila posterior follicle cells

This study shows that Hippo pathway inactivation reduces cytoophidium length and number in Drosophila posterior follicle cells, linking Hippo signaling to CTPS activity.

Exploring the Role of YAP1 and TAZ in Pancreatic Acinar Cells and the Therapeutic Potential of VT-104 in Pancreatic Inflammation

This study investigates the role of YAP1 and TAZ in pancreatic inflammation and evaluates the therapeutic potential of VT-104 in a mouse model of pancreatitis.

Aggressive high-grade NF2 mutant meningiomas downregulate oncogenic YAP signaling via the upregulation of VGLL4 and FAT3/4.

The paper shows that aggressive high-grade NF2 mutant meningiomas have reduced YAP1 activity due to increased VGLL4 and FAT3/4 expression, linked to higher recurrence risk.

Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling in Drosophila

The paper shows that Ds-Fat signaling regulates cell cycle duration scaling with wing size, affecting wing growth rate in Drosophila.