Hippo pathway signaling and YAP/TAZ

MITF maintains genome stability in non-melanocytic cell lineages and suppresses Hippo pathway signaling

This study shows MITF maintains genome stability in non-melanocytic cells by suppressing Hippo pathway signaling through LATS2 and ATR.

YAP/TAZ mechanotransduction is a fast cellular response to subnuclear adhesions revealed by mechanically dynamic substrates

The paper develops mechanically dynamic substrates to show YAP/TAZ respond rapidly to subnuclear adhesions during substrate stiffness changes.

PATJ regulates cell stress responses and vascular remodeling post-stroke

This study investigates the role of PATJ in cell stress responses and vascular remodeling after stroke using a mouse model and CRISPR-Cas9 knockout cells.

YAP controls cell migration and invasion through a Rho-GTPase switch

This study identifies YAP's role in controlling cell migration and invasion via a Rho-GTPase switch, with implications for glioblastoma progression.

Fat cadherin cleavage releases a transcriptionally active nuclear fragment to regulate target gene expression

The paper shows that the nuclear fragment of fat cadherin, generated by cleavage, regulates gene expression by interacting with Hippo pathway components and other factors.

Hippo-activated cells induce non-cell autonomous tumorigenesis in Drosophila

This study shows that activated Hippo pathway in Drosophila induces non-cell autonomous tumorigenesis through amino acid transporters and growth factors.

Chinmo is a novel regulator of differential response to Hippo signaling within a single developing organ

The paper identifies chinmo as a novel regulator enabling differential response to Hippo signaling between germ line and somatic cells in Drosophila larval ovary development.

Actin cytoskeletal deregulation, caused by RhoGEF2 overexpression, induces cell competition dependent on Ptp10D, Crumbs, and the Hippo signaling pathway.

The paper shows that RhoGEF2 overexpression causes actin cytoskeletal deregulation, leading to cell elimination via Ptp10D, Crumbs, and Hippo signaling in Drosophila.

BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis

This study identifies a BMAL1-YAP transcriptional complex that hijacks enhancers in aged epidermis to promote inflammation by rewiring chromatin dynamics and co-regulating inflammation-related genes with NF-KB.

Biomechanical Compartmentalisation Influences Angiogenesis and Stem Cell Proliferation in the Regenerating Intestine via Vascular Piezo.

This study identifies biomechanical compartmentalization in the regenerating intestine and shows vascular Piezo1 influences angiogenesis and stem cell proliferation across species.

Interpretable deep learning reveals the sequence rules of Hippo signaling

The paper uses interpretable deep learning to identify sequence rules governing Hippo signaling in mouse trophoblast stem cells, revealing how transcription factors influence enhancer activity.

The Hippo pathway effector YAP inhibits NF-kB signaling and ccRCC growth by opposing ZHX2

This study shows YAP inhibits NF-κB signaling and ccRCC growth by blocking ZHX2, a co-factor of NF-κB, and competes with ZHX2 for binding to p65.

Hippo signalling regulates the nuclear behaviour and DNA dwell times of YAP and TEAD to control transcription

This study uses live microscopy to show that Hippo signalling regulates transcription by controlling the DNA dwell times of YAP and TEAD proteins.

Characterization of Hippo Signaling Components in the Early Dorsal Pancreatic Bud

This paper investigates the expression and localization of Hippo signaling components during early pancreatic development in mice, finding distinct patterns of YAP1 and TAZ expression in progenitor and endocrine cells.

The N-terminus of the Chlamydia trachomatis effector Tarp engages the host Hippo pathway

This study identifies the N-terminal region of the Chlamydia effector Tarp as a regulator of host Hippo signaling, leading to increased cell survival and wing disc overgrowth in Drosophila.

The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells

This study identifies striatin-3 as a Rac1 interactor and shows its role in Schwann cell radial sorting and Hippo pathway regulation during peripheral nervous system development.

Influence of formaldehyde on signaling pathways when used in mammalian cell culture

This study shows that formaldehyde from fixation solutions can diffuse between wells and affect cellular signaling pathways like YAP and NF-κB in adjacent cultures.

Geometric, cell cycle and maternal-to-zygotic transition-associated YAP dynamics during preimplantation embryo development

This study quantifies YAP dynamics during preimplantation embryo development, showing that cell cycle mechanisms, not mechanical perturbations, primarily regulate YAP levels for cell fate decisions.

TEAD inhibition alters the lung immune microenvironment and attenuates metastasis.

This study shows TEAD inhibitors reduce lung metastases by altering immune signaling, enhancing anti-tumor immune responses, and changing macrophage and T-cell interactions.

The deubiquitylating enzyme Fat Facets promotes Fat signalling and restricts tissue growth

The paper identifies Fat facets as a deubiquitylating enzyme that promotes Fat signalling and is essential for tissue growth control.

YAP1-2α heterodimerization with TAZ promotes cancer aggressiveness through BRD4-dependent liquid-liquid phase separation at super-enhancers

This study shows YAP1-2α heterodimerization with TAZ promotes cancer aggressiveness via BRD4-dependent LLPS at super-enhancers, identifying it as a therapeutic target.

Ptpn14 Knockout Mice Reveal Critical Female-Specific Roles for the Hippo Pathway

This study shows that Ptpn14 deficiency in mice causes female-specific Hippo pathway defects, including corneal lesions, uterine defects, and organ abnormalities, with conserved roles in humans.

Competitive elimination of ZO-1/ZO-2-deficient cells regulates epithelial barrier homeostasis

The paper shows that ZO-1/ZO-2-deficient cells are selectively eliminated by cell competition, mediated by supracellular actomyosin cables and Hippo signaling, to maintain epithelial barrier homeostasis.

Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma

This study investigates the interaction between PANX1 and the Hippo pathway in melanoma, showing PANX1 modulates YAP levels and identifies potential therapeutic targets.

Deep learning uncovers histological patterns of YAP1/TEAD activity related to disease aggressiveness in cancer patients.

This study uses deep learning to predict YAP1/TEAD activity from histology slides, linking histological patterns to disease aggressiveness in cancer patients.

YAP engages RIF1 to dampen replication stress-induced DNA damage in human squamous cell carcinoma.

This study identifies YAP's interaction with RIF1 in squamous cell carcinoma, showing it reduces replication stress-induced DNA damage through non-transcriptional mechanisms.

Control of mitochondrial dynamics by dPGC1 limits Yorkie-induced oncogenic growth in Drosophila

This study shows that dPGC1 limits Yki-driven oncogenic growth in Drosophila by regulating mitochondrial dynamics and cell cycle regulation.

A Dual Role for the PP2A Phosphatase in Hippo Signalling Regulation

This study shows that PP2AWrd activates Hippo signaling by stabilizing Expanded, contrasting with PP2ACka's inhibitory role, and reveals interactions with Kibra and Crumbs in regulating Expanded proteostasis.

Nuclear receptor E75/NR1D2 drives tumor malignant transformation by integrating Hippo and Notch pathways

The paper shows that E75/NR1D2 integrates Hippo and Notch pathways to drive tumor malignancy in response to hormone inhibition.

The L27 Domain of MPP7 enhances TAZ-YY1 Cooperation to Renew Muscle Stem Cells

The paper identifies a mechanism by which the L27 domain of MPP7 enhances TAZ-YY1 cooperation to drive muscle stem cell renewal through up-regulation of Carm1.