Hippo pathway signaling and YAP/TAZ

The Hippo kinase LATS1 controls CTCF chromatin occupancy and the hormonal response of three-dimensionally grown breast cancer cells

This study shows that 3D culture of breast cancer cells alters chromatin structure and gene expression, with LATS1 kinase playing a key role in CTCF displacement and hormonal response.

Ultra-sensitive coupling between organ growth and size by YAP-1 ensures uniform body plan proportions in C. elegans

The paper shows that YAP-1 coordinates organ growth with body size in C. elegans to maintain uniform proportions, even under tissue-specific growth inhibition.

Combined inactivation of RB and Hippo pathways converts differentiating photoreceptors into eye progenitor cells through derepression of homothorax

The paper shows that inactivating RB and Hippo pathways in Drosophila photoreceptors causes dedifferentiation by derepressing homothorax, revealing their cooperative role in maintaining neuronal identity.

LSR Targets YAP to Modulate Intestinal Paneth Cell Differentiation

This study identifies LSR as a negative regulator of YAP activity, essential for Paneth cell differentiation and a potential therapeutic target for inflammatory bowel disease.

A noncanonical repressor function of JUN restrains YAP activity and suppresses YAP-dependent liver cancer growth

This study identifies c-JUN as a noncanonical repressor of YAP/TAZ that suppresses their oncogenic activity in liver cancer.

The cell adhesion molecule Echinoid promotes tissue survival and separately restricts tissue overgrowth in Drosophila imaginal discs

This study identifies Echinoid's dual role in promoting tissue survival via Diap1 and restricting overgrowth by arresting growth at final size in Drosophila imaginal discs.

Transcriptional and epigenomic profiling identifies YAP signaling as a key regulator of intestinal epithelium maturation

Downregulation of Yap1 During Limb Regeneration Results in Defective Bone Formation in Axolotl

This study shows that downregulating Yap1 in axolotl limb regeneration impairs bone formation, highlighting its role in regeneration through protease inhibition, immune activity, and ECM changes.

Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye

This study identifies the Hippo pathway's role in Drosophila eye development through the interaction of Yorkie and Bonus, showing they control cell fate by promoting epidermal and antennal fates over eye fate.

Coordinated growth of linked epithelia is mediated by the Hippo pathway

The paper shows that the Hippo pathway enables the peripodial epithelium to adapt its growth to the disc proper in Drosophila, using mechanical signals rather than morphogens.

Oncogenic YAP mediates changes in chromatin accessibility and activity that drive cell cycle gene expression and cell migration

This study shows that oncogenic YAP alters chromatin accessibility and activity, driving cell cycle gene expression and migration through enhancer-mediated mechanisms.

YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulated bone development

This study shows YAP and TAZ regulate osteoblast precursor mobilization and angiogenesis during bone development, linking mechanical cues to vascular and bone formation.

Mechanisms underlying divergent relationships between Ca2+ and YAP/TAZ signaling

This study develops a network model to investigate how Ca2+ dynamics and signaling crosstalk influence YAP/TAZ activity, revealing frequency-dependent responses and non-monotonic behavior under different stimuli.

Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury

The paper uses PDE modeling and image analysis to show that nuclear phosphorylation and AKT interaction regulate YAP and TAZ shuttling dynamics in response to APAP-induced liver injury.

A non-transcriptional function of Yap orchestrates the DNA replication program

This study shows Yap regulates DNA replication dynamics and interacts with Rif1 to control replication timing in early embryos and stem cells.

The native cell differentiation program aberrantly recapitulated in yki3S/A-induced intestinal hyperplasia drives invasiveness and cachexia-like wasting phenotypes

This study shows that a native differentiation program in intestinal tumors drives invasiveness and cachexia-like wasting by recapitulating enterocyte development in Drosophila.

DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells

The paper shows that DNA damage induces apoptosis in zebrafish yap1-/-;wwtr1-/- epidermal basal cells, with substrate stiffness modulating genomic stress and cell survival.

Stromal Hippo-YAP signaling in stem cell niche controls intestinal homeostasis

This study identifies the role of stromal Hippo-YAP signaling in maintaining intestinal homeostasis by regulating stem cell niche function and epithelial regeneration.

Role of YAP in early ectodermal specification anda Huntington's Disease model of human neurulation

This study investigates YAP's role in early ectodermal specification and its link to Huntington's Disease using human neuruloids, finding YAP activation influences ectodermal fate and that reducing YAP activity can partially rescue HD phenotypes.

Systematic dissection of phosphorylation-dependent YAP1 complex formation elucidates a key role for PTPN14 in Hippo signal integration

The paper develops an experimental strategy to link phosphorylation events with protein complex formation, revealing PTPN14's role in regulating YAP1's interaction with LATS1/2 kinases.

Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair

The paper shows that YAP activation in Procr+ ovarian progenitors is essential for OSE repair and stem/progenitor expansion through reduced Vgll4 expression and increased Procr transcription.

A Yap-dependent transcriptional program directs cell migration for embryo axis assembly

This study shows that Yap proteins are essential for cell migration during embryo axis formation by regulating cytoskeletal organization and cell-ECM adhesion in medaka.

An ancient role for the Hippo pathway in axis formation and morphogenesis

The paper shows the Hippo pathway regulates axis formation in Hydra, upstream of Wnt, by controlling budding, actin organization, and cell proliferation.

Live imaging YAP signaling in mouse embryo development

This study develops a YAP fusion reporter mouse line and uses live imaging to analyze YAP localization dynamics during mouse embryonic development.

YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation

This study identifies YAP and TAZ as transcriptional co-activators of AP-1 and STAT3 in breast cancer, showing their role in gene regulation and poor patient survival.

YAP/TAZ Maintain the Proliferative Capacity and Structural Organization of Radial Glial Cells During Brain Development

This study shows YAP/TAZ are essential for maintaining radial glial cell function during brain development, affecting neuronal and ependymal cell numbers and causing hydrocephaly when disrupted.

Crumbs and the Apical Spectrin Cytoskeleton Regulate R8 Cell Fate in the Drosophila eye

This study identifies Crumbs and the apical spectrin cytoskeleton as regulators of R8 cell fate in Drosophila eye, distinct from their role in Hippo-dependent organ growth.

Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues

The paper identifies a small-molecule inhibitor of Lats kinases that promotes Yap-dependent proliferation in postmitotic mammalian tissues, enabling hair cell regeneration in the inner ear.

Targeted quantification of phosphorylation sites identifies STRIPAK-dependent phosphorylation of the Hippo pathway-related kinase SmKIN3

The paper identifies STRIPAK-dependent phosphorylation sites in SmKIN3 and shows their impact on septation in Sordaria macrospora.

The Hippo pathway transcriptional co-activator YAP is involved in head regeneration and bud development in Hydra

This study identifies the Hippo pathway components in Hydra and shows their role in head regeneration and bud development through YAP expression patterns and functional analysis.