Hippo pathway signaling and YAP/TAZ

Hippo signaling regulates cuticle pigmentation and dopamine metabolism in Drosophila

This study identifies the role of Hippo signaling in regulating cuticle pigmentation and dopamine metabolism in Drosophila through genetic and transcriptomic analyses.

The Hippo Signaling Pathway Regulates Corneal Endothelial Regeneration

This study identifies the Hippo signaling pathway's role in regulating corneal endothelial regeneration across species, showing that YAP activation promotes wound healing and suggesting it as a therapeutic target.

Targeting stiffness-dependent YAP/TAZ restores angiogenesis dynamics impaired by ALK1 knockout in silico

The paper uses computational modeling to show that ALK1 knockout impairs angiogenesis by affecting YAP/TAZ signaling and endothelial phenotypic selection, suggesting YAP/TAZ targeting could restore vascular function in HHT.

Homer condensates orchestrate YAP-Wnt signaling crosstalk downstream of the Crumbs polarity complex

This paper shows Homer proteins form condensates that link cell polarity to YAP-Wnt signaling by modulating condensate structure and pathway activity.

Regulation of Hippo signaling by Atrophin in the developing Drosophila wing

The paper investigates how Atrophin modulates Hippo signaling in Drosophila wing development through distinct mechanisms in different regions.

Cell heterogeneity and fate bistability drive tissue patterning during intestinal regeneration

The paper identifies how cell heterogeneity and YAP1 inactivation drive tissue patterning during intestinal regeneration through feedback mechanisms.

Constitutive Yap activation in distal nephron segments disrupts epithelial identity and nephron patterning

This study shows that constitutive Yap activation in distal nephron segments disrupts epithelial identity and nephron patterning by altering cell proliferation, lineage boundaries, and gene expression.

aPKC-ζ III promotes trophoblast fusion by altering Par-3 interactions with Hippo Signaling Kinase LATS1

This study identifies aPKC-ζ III as a regulator of trophoblast fusion by modulating Hippo signaling through its interaction with Par-3 and LATS1.

TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells

The paper shows TEAD1 forms transcriptionally inactive condensates in cancer cell pericentromeric heterochromatin, acting as storage sites and influencing YAP/TEAD target gene expression.

Sustained Yap/Taz activation promotes aberrant alveolar epithelial cell differentiation and drives persistent fibrotic remodeling

This study shows sustained Yap/Taz activation in alveolar epithelial cells leads to fibrotic remodeling and impaired repair, with potential therapeutic implications.

The Rho effector ARHGAP18 coordinates a Hippo pathway feedback loop through YAP and Merlin to regulate the cytoskeleton and epithelial cell polarity.

This study identifies ARHGAP18 as a RhoA effector that forms a complex with YAP to coordinate Hippo and Rho pathways in regulating actin cytoskeleton and epithelial polarity.

Vgll4 Proteins limit Organ Size in Zebrafish through Yap1-Dependent and -Independent Mechanisms

This study shows Vgll4 proteins regulate zebrafish organ size by both enhancing and limiting Yap1 activity in the posterior lateral line primordium.

Cisplatin-induced oxidative stress regulates YAP to modulate epigenome promoting survival of osteosarcoma cells

This study shows that cisplatin induces oxidative stress, leading to epigenetic repression via YAP and promoting osteosarcoma cell survival.

Degradation of the TEAD-YAP/TAZ Transcription Factor Complex by Heterobifunctional Small Molecules that Bind to the TEAD Allosteric Lipid Pocket

This study designs and tests heterobifunctional small molecules to degrade the TEAD-YAP/TAZ complex in cancer cells, showing significant proteasomal degradation with methyl ester analogs.

Domain-specific mechanisms of YAP1 variants in ocular coloboma revealed by in-vitro and organoid studies

The paper investigates YAP1 variants' role in ocular coloboma using in vitro and organoid studies, showing how missense variants affect YAP1-TEAD binding and transcriptional activity.

Hippo signaling differentially regulates distal progenitor subpopulations and their transitional states to construct the mammalian lungs

This study uses single-cell analyses to show Hippo signaling regulates SOX9+ progenitor subpopulations and their transitions to generate lung structures in mice, with some parallels in human lungs.

Integrin-binding matricellular protein fibulin-5 maintains epidermal stem cell heterogeneity during skin aging

This study shows that fibulin-5 maintains epidermal stem cell heterogeneity during aging by regulating integrin expression and YAP signaling.

Autophagy-Dependent Regulation of YAP1 by STK38 Governs Recruitment of Differentiated Cells as Progenitor Cells During Regeneration

The paper identifies STK38 as a YAP1 kinase that regulates paligenosis by autophagy-dependent degradation, enabling differentiated cells to act as progenitors during tissue regeneration.

Inflammatory macrophages drive smooth muscle dedifferentiation via YAP signaling in murine deep vein thrombosis

This study shows that inflammatory macrophages suppress YAP signaling in smooth muscle cells, driving their dedifferentiation in murine deep vein thrombosis.

YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast

The paper identifies YAP1 and QSER1 as key regulators of developmental signaling pathways in the mammalian epiblast, showing their role in maintaining pluripotency and preventing excessive differentiation.

Regulation of YAP activity by nuclear G-actin binding

This study identifies three high affinity G-actin binding sites in YAP and shows that actin binding is necessary for YAP's transcriptional activity and function.

The Extracellular Matrix Regulates Invasion in Fusion-Negative Rhabdomyosarcoma via YAP-PIEZO1 Signaling Axis

This study identifies a YAP-PIEZO1 signaling axis that links extracellular matrix density to invasion in fusion-negative rhabdomyosarcoma, with therapeutic implications.

The role of YAP/TAZ signaling in dendritic cell-mediated pathogenesis of insulin resistance and non-alcoholic fatty liver disease

This study investigates the role of YAP/TAZ in dendritic cell-mediated pathogenesis of insulin resistance and NAFLD using a high-fat diet model, finding minimal impact on disease progression.

PI3K regulates TAZ/YAP and mTORC1 axes that can be synergistically targeted

This study identifies PI3K-regulated TAZ/YAP and mTORC1 pathways in sarcomas and shows that targeting both synergistically reduces tumor growth.

HCV infection induces ubiquitin-dependent degradation of LATS1, inactivating the Hippo pathway and upregulating transcription of the CYR61 and CTGF genes

This study shows HCV infection causes LATS1 degradation via ubiquitin-mediated proteasomal pathway, inactivating the Hippo pathway and increasing CYR61 and CTGF gene transcription.

aPKC and F-actin Dynamics Promote Hippo Pathway Polarity in Asymmetrically Dividing Neuroblasts

This study shows that Kibra and Salvador polarize to the apical cortex of neuroblasts, and their localization is driven by aPKC activity and F-actin dynamics.

Regulation of tension-dependent localization of LATS1 and LATS2 to adherens junctions.

This study identifies the molecular mechanism by which LIMD1 recruits LATS1/2 to adherens junctions through LIM domains and an N-terminal IDR, mediated by a conserved LATS-LATCH motif.

Transient proliferation by reversible YAP and mitogen-control of the cyclin D1/p27 ratio

The paper shows YAP and mitogen signaling regulate the cyclin D1/p27 ratio during G1 phase, determining cell cycle entry or exit through receptor-mediated mechanisms and contact inhibition.

Aberrant Hippo-YAP/TEAD signaling drives malignant transcriptional reprogramming in external auditory canal squamous cell carcinoma

This study identifies hyperactivation of YAP/TEAD signaling in EACSCC and shows that targeting TEAD or PITX2 can suppress tumor growth and predict poor prognosis.

YAP1 Contributes to The Development of Contractile Force and Sarcomere Maturation in Human Pluripotent Stem Cell Derived Cardiomyocytes

This study shows YAP1 promotes cardiomyocyte maturation, sarcomere structure, and contractility in human stem cell-derived cardiomyocytes.