Hippo pathway signaling and YAP/TAZ

An interaction between Yorkie and Taiman transcriptional coactivators regulates niche-to-stem cell BMP signaling in the female Drosophila germline

This study shows that the Yki:Tai interaction in Drosophila germline niche escort cells regulates BMP signaling and maintains stem cell fate by controlling Dpp ligand spread.

TRIP6 condensates constrain Hippo pathway hyperactivation under osmotic stress

This study shows TRIP6 condensates regulate Hippo pathway activity under osmotic stress by modulating LATS1 and YAP phosphorylation, preventing excessive pathway activation.

ESCRT-dependent YAP degradation by AKT blockade overcomes adaptive resistance to RAS(ON) inhibition in pancreatobiliary cancer

This study identifies AKT as a regulator of YAP stability and shows that AKT inhibition triggers ESCRT-dependent YAP degradation, enhancing the efficacy of RAS inhibition in pancreatobiliary cancers.

YAP/TAZ-controlled ERK dynamics coordinate progenitor expansion and differentiation commitment

This study shows YAP/TAZ control ERK dynamics to balance progenitor expansion and differentiation by modulating PPARG activation thresholds and Hippo signaling.

Spatio-temporal visualisation and manipulation of endogenous Yap1 in medaka

This study develops a tool to visualize and manipulate endogenous Yap1 in medaka, revealing its dynamics during development and regeneration.

Integrin α11 is enriched in quiescence and promotes cell-cycle re-entry through destabilisation of the CDK inhibitor p27

The paper identifies integrin α11 as a quiescence signature protein that promotes cell-cycle re-entry by destabilizing the CDK inhibitor p27 through YAP-dependent regulation.

Profilin1 regulates triple negative breast cancer cells migration through stabilization of Angiomotin and thereby YAP nuclear translocation

This study identifies Profilin1 as a stabilizer of Angiomotin, which inhibits YAP nuclear translocation and suppresses TNBC cell migration.

Functional divergence of WWC family proteins in human endothelial cells

This study identifies distinct roles for WWC2 and WWC3 in human endothelial cells, showing WWC3's dominance in Hippo signaling and WWC2's role in VEGF signaling, with both affecting EC proliferation and migration.

Hippo signaling regulates cuticle pigmentation and dopamine metabolism in Drosophila

This study identifies the role of Hippo signaling in regulating cuticle pigmentation and dopamine metabolism in Drosophila through genetic and transcriptomic analyses.

YAP-TEAD-driven CPA4 promotes NF2-deficient meningioma growth

This study identifies CPA4 as a YAP-TEAD-driven effector in NF2-deficient meningioma, showing its role in tumor growth and sensitivity to TEAD inhibitors.

Cell-type-specific decoding of Hippo pathway inactivation drives seminiferous epithelial collapse and rete testis hyperplasia in the adult mouse testis

This study shows that deleting Lats1/2 in adult mouse testis cells causes seminiferous epithelial collapse and rete testis hyperplasia through distinct transcriptional responses in Sertoli and rete testis epithelial cells.

Preclinical Characterization of Hippo pathway inhibition: Insights from Pharmacological and Genetic Studies

This paper investigates the effects of Hippo pathway inhibition through pharmacological and genetic approaches, identifying kidney, pancreas, and thymus as target organs with dose-dependent toxicities.

Prohaptoglobin Promotes Pancreatic Cancer Progression by sustaining YAP Activity

This paper shows prohaptoglobin promotes pancreatic cancer by sustaining YAP activity, enabling cells to bypass contact inhibition and enhance motility and tumor growth.

The Hippo Signaling Pathway Regulates Corneal Endothelial Regeneration

This study identifies the Hippo signaling pathway's role in regulating corneal endothelial regeneration across species, showing that YAP activation promotes wound healing and suggesting it as a therapeutic target.

Targeting stiffness-dependent YAP/TAZ restores angiogenesis dynamics impaired by ALK1 knockout in silico

The paper uses computational modeling to show that ALK1 knockout impairs angiogenesis by affecting YAP/TAZ signaling and endothelial phenotypic selection, suggesting YAP/TAZ targeting could restore vascular function in HHT.

Homer condensates orchestrate YAP-Wnt signaling crosstalk downstream of the Crumbs polarity complex

This paper shows Homer proteins form condensates that link cell polarity to YAP-Wnt signaling by modulating condensate structure and pathway activity.

Regulation of Hippo signaling by Atrophin in the developing Drosophila wing

The paper investigates how Atrophin modulates Hippo signaling in Drosophila wing development through distinct mechanisms in different regions.

Optic cup folding is driven by the geometry and tension of the Retinal Pigmented Epithelium (RPE) cells

The paper investigates how Wnt/β-catenin and YAP pathways regulate RPE cell geometry and tension during optic cup folding, showing their role in mechanical properties and nuclear signaling.

Cell heterogeneity and fate bistability drive tissue patterning during intestinal regeneration

The paper identifies how cell heterogeneity and YAP1 inactivation drive tissue patterning during intestinal regeneration through feedback mechanisms.

Constitutive Yap activation in distal nephron segments disrupts epithelial identity and nephron patterning

This study shows that constitutive Yap activation in distal nephron segments disrupts epithelial identity and nephron patterning by altering cell proliferation, lineage boundaries, and gene expression.

aPKC-ζ III promotes trophoblast fusion by altering Par-3 interactions with Hippo Signaling Kinase LATS1

This study identifies aPKC-ζ III as a regulator of trophoblast fusion by modulating Hippo signaling through its interaction with Par-3 and LATS1.

Flow-Induced Yap/Taz Signaling Balances Endothelial and Hematopoietic Stem Cell Fates

This study shows that hemodynamic forces activate YAP signaling via Piezo1 in hemogenic endothelium, promoting HSC production by regulating metabolic and gene regulatory programs, while TAZ overactivation disrupts this balance.

TEAD1 condensates are transcriptionally inactive storage sites on the pericentromeric heterochromatin in cancer cells

The paper shows TEAD1 forms transcriptionally inactive condensates in cancer cell pericentromeric heterochromatin, acting as storage sites and influencing YAP/TEAD target gene expression.

Sustained Yap/Taz activation promotes aberrant alveolar epithelial cell differentiation and drives persistent fibrotic remodeling

This study shows sustained Yap/Taz activation in alveolar epithelial cells leads to fibrotic remodeling and impaired repair, with potential therapeutic implications.

Piezo1 links cytoskeletal remodeling to differential YAP and β-catenin signaling in response to mechanical cues

This study shows Piezo1 links mechanical cues to cytoskeletal changes and differential YAP/β-catenin signaling in breast cancer cells.

YAP/TAZ inhibition refines TGF-β signaling to prevent laryngeal fibrosis

This study shows YAP/TAZ inhibition selectively reduces pro-fibrotic TGF-β signaling in vocal fold fibroblasts, preventing fibrosis in a rat model.

Modeling Meibomian Gland Development and Dysfunction: A Mouse-Derived Organoid System Reveals Hippo-YAP as a Critical Regulator

This study develops a mouse-derived organoid model of meibomian glands and identifies the Hippo-YAP pathway as critical for gland development and dysfunction.

Pathway-Centric Integration of CRISPR Fitness with Molecular Features Draws Cancer State Maps

StateMap integrates CRISPR fitness and gene expression data to map cancer pathway states, identifying therapeutic vulnerabilities in the Hippo pathway.

The Rho effector ARHGAP18 coordinates a Hippo pathway feedback loop through YAP and Merlin to regulate the cytoskeleton and epithelial cell polarity.

This study identifies ARHGAP18 as a RhoA effector that forms a complex with YAP to coordinate Hippo and Rho pathways in regulating actin cytoskeleton and epithelial polarity.

Endothelial YAP/TAZ rewiring under cardiometabolic stress drives sex-divergent vascular remodeling in heart failure with preserved ejection fraction

This study identifies endothelial YAP/TAZ signaling as a driver of sex-divergent vascular remodeling in HFpEF, linking cardiometabolic stress to microvascular changes through YAP1 and ESM1.