Parkinson's Disease Mechanisms and Treatments

Integrative Transcriptomic Analysis Identifies Novel Mitochondrial Gene Targets in Parkinson's Disease.

This study identifies novel mitochondrial gene targets in Parkinson's disease by analyzing RNA-seq data from multiple datasets and validating findings through experimental models.

Tegmental atrophy in isolated REM sleep behaviour disorder: Ex vivo-informed in vivo imaging

This study identifies tegmental atrophy in iRBD using VBM and a novel brainstem atlas, linking atrophy in specific nuclei to autonomic dysfunction.

Parkinson's disease-associated LRRK2 risk variant, G2385R, enhances Rab substrate phosphorylation and impairs neuronal integrity

This study evaluates how LRRK2 coding variants affect protein function and neurotoxicity, finding that G2385R increases Rab10 phosphorylation and impairs neuronal integrity.

Change in movement disorder specialist attitudes to genetic testing after implementation of PD GENEration

A survey found increased comfort and willingness among movement disorder specialists to order genetic testing for Parkinson's disease after the implementation of PD GENEration.

Comprehensive genetic screening of the South African Parkinson's disease study collection using the NeuroBooster array

This study performs genetic screening of South African Parkinson's disease patients, identifying rare variants and CNVs in known PD genes, highlighting their contribution to disease in an underrepresented population.

Striatal dopamine synthesis capacity in Parkinson's disease: Effects of age, sex, and body mass index in a large fluorodopa PET cohort

This study investigates how age, sex, and BMI affect striatal dopamine synthesis capacity in Parkinson's disease patients and healthy controls using PET data.

Chlorogenic acid fails to confer neuroprotection in a chronic mouse model of Parkinsons disease

This study shows that chlorogenic acid provides neuroprotection in vitro but not in vivo in a chronic Parkinson's disease mouse model.

Variants in DNAJC13 Are Not Associated with Parkinson's Disease Across Different Ancestral Backgrounds

The paper investigates the association between DNAJC13 variants and Parkinson's disease across diverse ancestries but finds no significant association.

Alpha-synuclein amyloids catalyze the degradation of ATP and other nucleotides

This study shows alpha-synuclein amyloids degrade ATP and other nucleotides catalytically, contributing to energy depletion in neurodegenerative diseases.

Insights into X-Linked Susceptibility to Parkinson's Disease in the South African Population

This study conducts the first XWAS in an African cohort, identifying X chromosome variants associated with Parkinson's disease susceptibility in males and females.

mGluR4-Npdc1 complex mediates α-synuclein fibril-induced neurodegeneration

This study identifies mGluR4 and Npdc1 as cell surface proteins that mediate α-synuclein fibril binding and neurodegeneration in Parkinson's disease models.

Age-related differences in the association between REM sleep and the polygenic risk for Parkinson's disease

The paper examines how polygenic risk for Parkinson's disease relates to REM sleep metrics in young and late-midlife individuals, finding age-dependent associations.

Cryo-EM structure of alpha-Synuclein Fibrils Harboring the Dementia with Lewy Bodies - Associated E83Q Mutation

The paper determines the cryo-EM structure of alpha-synuclein fibrils with the E83Q mutation, revealing structural changes linked to enhanced aggregation and pathogenicity.

Parkinsonism Reversal and Dopaminergic Resilience: Lessons from a Rotenone-induced Parkinson's Disease Model

This study shows that rotenone-induced Parkinsonism in mice is reversible, with full recovery of motor and non-motor deficits and dopaminergic neuron density after 12 months.

Behavior- and Cell Type-Specific Cortico-Striatal Activity Decoupling in a Parkinson's Disease-Like Mouse Model

The paper shows that cortico-striatal activity decoupling occurs early in a Parkinson's Disease-like mouse model and is cell-type and behavior-specific.

Ser129 Phosphorylation Paradox: Non-phosphorylated α-Synuclein Drives Parkinson' s Disease-like Pathogenesis in Vivo

This study shows that non-phosphorylated α-synuclein drives Parkinson's disease-like pathogenesis in mice, contradicting the traditional view that phosphorylated α-synuclein is pathogenic.

Helicobacter pylori infection and α-synuclein pathology drive parallel neurodegenerative pathways in the substantia nigra

This study shows chronic H. pylori infection causes brain inflammation and dopaminergic neuron loss through inflammation, independent of α-synuclein pathology, and eradication reduces these effects.

Pathway Anchored Multimodal Clustering Reveals Circuit Level Signatures in Parkinsons Disease

The paper introduces a pathway-anchored clustering framework to analyze multimodal imaging data in Parkinson's disease, identifying stable patient clusters and structure-function associations.

PIKfyve inhibition induces LRRK2 activation through phosphatidylinositol 3-phosphate and CASM

This study shows that PIKfyve inhibition leads to LRRK2 hyperactivation through PI3P and CASM, revealing a new mechanism involving membrane lipids and Rab proteins.

A human multilineage gut organoid model for Parkinson disease

This paper develops a human gut organoid model incorporating PD-relevant cell types to study gut-brain pathways in Parkinson disease.

GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis

This study identifies GPNMB as a biomarker for lysosomal dysfunction and shows it is secreted via LRRK2-modulated lysosomal exocytosis in macrophages.

Gasdermin E couples mitochondrial damage to pyroptotic neurodegeneration in Parkinson disease

This paper identifies GSDME as a mediator of neurodegeneration in Parkinson's disease by linking mitochondrial damage to pyroptotic cell death through caspase-3 activation.

Phosphorylation of α-synuclein fibrils at S129 changes DNAJB1 binding as probed by solid-state NMR

This study investigates how phosphorylation of α-synuclein at S129 affects DNAJB1 binding to fibrils using biochemical assays and solid-state NMR.

Bioenergetic and Protein Processing Imbalances Synergize in iPSC-Dopamine neurons from Individuals with Idiopathic Parkinsons Disease

This study examines bioenergetic and protein processing defects in iPSC-derived dopamine neurons from idiopathic Parkinson's disease patients, revealing impaired mitochondrial function and alpha synuclein aggregation.

The Pesticide Chlorpyrifos Increases the Risk of Parkinson's Disease

This paper investigates the association between chlorpyrifos exposure and Parkinson's disease risk, finding increased odds of PD with long-term exposure and demonstrating causal mechanisms in animal models.

Epoxyazadiradione ameliorates Parkinson's disease by upregulating heat shock factor 1 and protein degradation pathways in mice.

This paper identifies Epoxyazadiradione as a compound that improves Parkinson's disease symptoms in mice by enhancing heat shock factor 1 and protein degradation pathways without affecting redox balance.

Lack of functional STING modulates immunity but does not protect dopaminergic neurons in the alpha-synuclein preformed fibrils Parkinson's Disease mouse model

The paper investigates the role of STING in Parkinson's disease by comparing motor behavior and brain pathology in STING-deficient and wild-type mice exposed to alpha-synuclein fibrils.

Phospho-signalling deregulation of the mTOR pathway in fibroblasts from LRRK2 Parkinson s patients

This study identifies mTOR pathway deregulation in fibroblasts from LRRK2 Parkinson's patients through proteomic and phospho-proteomic analysis.

Electroconvulsive Therapy Induces Dopaminergic Axon Regeneration, Corticostriatal Remodeling, and Restoration of Motor Function in Parkinsonian Mice

This study shows that electroconvulsive therapy (ECT) improves motor function in Parkinsonian mice by promoting dopaminergic axon regeneration and restoring striatal circuitry.

No Evidence for Genetic Role of the Tumor Necrosis Factor Pathway in Parkinson's Disease

This study uses Mendelian Randomization to test if TNF pathway genes are genetically linked to Parkinson's disease or RBD, finding no evidence of such a link.