Inflammatory Bowel Disease

Bioactive produced by Enterococcus Faecalis targets IL-23 signalling and protects against colitis and joint disease

This study identifies a bioactive compound from Enterococcus faecalis that suppresses IL-23 signaling and reduces inflammation in gut and joint diseases.

JAK and TYK2 inhibitors differentially modulate interferon/TNF-driven inflammation, stemness and proliferation in the colonic epithelium of ulcerative colitis

This study examines how JAK/TYK2 inhibitors affect epithelial responses in UC, showing differential modulation of inflammation, stemness, and proliferation.

A preliminary study of HMGB1 defense in Crohn's disease

This study examines HMGB1 defense in Crohn's disease, finding reduced surface-associated HMGB1 and intestinal barrier defects in active lesions.

Cdc42 small GTPase is a novel regulator of the fibrogenic activation of human intestinal myofibroblasts

This study shows that Cdc42 regulates fibrogenic activation of human intestinal myofibroblasts by enhancing ECM production and contractile actomyosin cytoskeleton through AKT-mTOR signaling.

Lamin A/C regulates the compartment-specific contributions of immune and stromal cells to intestinal inflammation and colitis-associated colon cancer

This study identifies lamin A/C as a regulator of intestinal inflammation and tumorigenesis by modulating immune and stromal cell functions in mouse models and human IBD biopsies.

The primary sclerosing cholangitis and ulcerative colitis colonic mucosa defined through paired microbial and single-cell RNA sequencing

This study identifies distinct cellular and microbial profiles in PSC-UC and UC patients using single-cell and spatial transcriptomics, revealing shared and unique inflammatory mechanisms.

Single-cell analysis of an adult IBD INCEPTION cohort reveals Galectin-linked disease mechanisms

The paper uses single-cell data from an IBD cohort to identify Galectin-linked disease mechanisms in early IBD.

Enhanced environmental complexity worsens experimental colitis and dysregulates microbiota-gut-brain axis signalling in female mice

This study shows that enhanced environmental complexity worsens colitis in female mice and disrupts microbiota-gut-brain axis signaling.

PKN2 regulates cell-junctions to limit colitis

This study identifies PKN2 as a regulator of tight junctions that limits colitis and colorectal cancer by maintaining intestinal barrier integrity during inflammation.

Tissue-embedded CD4⁺ plasticity defines mucosal immunity in Inflammatory Bowel Disease

This study maps CD4 T cell plasticity and spatial organization in IBD tissues, revealing regulatory-Th17 plasticity and interactions with CD8 cells.

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn's Disease Pathogenesis.

The paper identifies molecular signatures of Crohn's disease using scRNA-seq data from terminal ileal biopsies, highlighting key cell types and pathways involved in disease pathogenesis.

A stromal-state dichotomy governs recalcitrance or remission in inflammatory bowel disease

This paper identifies two stromal states in IBD that predict clinical outcomes and shows that targeting one state can reverse disease pathology.

Persistent stromal reprogramming defines incomplete mucosal healing and predicts therapeutic response in ulcerative colitis

The paper identifies persistent stromal reprogramming in mucosal healing of ulcerative colitis and links it to therapeutic response prediction.

Estrogen Impacts Nod2-Dependent Regulation of Intestinal Homeostasis

This study identifies a NOD2-estrogen regulatory axis in zebrafish that impacts intestinal homeostasis, showing estrogen can replicate NOD2-deficiency effects and be reversed by tamoxifen.

Novel mouse models for perianal fistulizing Crohns disease reveal therapeutic value of interferon-gamma antagonists

This study develops mouse models of perianal fistulizing Crohn's disease and identifies IFN-gamma signaling as a therapeutic target.

Procedure-Matched Comparison of TNBS/Ethanol Enema and DSS Free-Drinking Models of Ulcerative Colitis in Rats: Immune Endotype Profiling and a Translational Model-Selection Framework

This paper compares TNBS/ethanol enema and DSS free-drinking models of UC in rats, showing TNBS induces higher Th1-polarized inflammation and DSS reflects innate barrier disruption, with recommendations for model selection based on therapeutic targets.

Hepatic stearoyl-CoA desaturase-1 is specifically suppressed by dextran sodium sulfate but does not influence colitis sensitivity

This study shows that DSS-induced colitis suppresses hepatic SCD1 without affecting colitis severity, and reveals lipid metabolism changes in the liver and plasma.

FOXP3-engineered regulatory T cells restore intestinal barrier integrity in Crohn's disease enteroids via PDGF-AA

FOXP3-engineered regulatory T cells enhance intestinal barrier function in Crohn's disease enteroids via the PDGF-AA-PDGFR axis, independent of their immunosuppressive role.

Epithelial stem cell-derived chemokines track clinical remission in inflammatory bowel disease in a disease-specific manner

The paper shows that chemokines in UC organoids correlate with clinical remission and treatment response, but not in Crohn's disease.

Resolving inflammatory bowel disease risk variants to genes and cell types

This study identifies 619 IBD risk signals, resolves 81 high-confidence variants, and prioritizes 664 candidate effector genes using GWAS, eQTL, and exome sequencing.

Peyer's patches are a niche for antibiotic-driven expansion of Crohn's disease-associated adherent-invasive Escherichia coli

This study shows antibiotic treatment increases AIEC burden in Peyers patches, leading to focal inflammation, and identifies specific AIEC traits required for niche colonization and immunopathology.

A proteomic polygenic score to identify IL-18 driven inflammatory bowel disease

The paper develops a proteomic polygenic score to predict IL-18 levels and IBD risk, identifying ~30% of IBD patients as IL-18 High.

Exome sequencing directly implicates 68 genes in inflammatory bowel disease

This study uses exome and genome sequencing to identify 68 genes directly associated with inflammatory bowel disease, providing clearer genetic insights and therapeutic targets.

Inflammatory Stromal Aging in Ulcerative Colitis and Colitis-Associated Cancer

This study investigates how inflammatory fibroblasts in ulcerative colitis and colitis-associated cancer contribute to disease progression through senescence and epigenetic memory.

In vivo colonic epithelial cell editing attenuates intestinal inflammation in mice

The paper shows that editing colonic epithelial cells in vivo to enhance efferocytosis reduces intestinal inflammation in mice.

Fatty Acid Oxidation Suppression Reprograms Fibroblasts in Fibrostenotic Crohns Disease

The paper identifies impaired fatty acid oxidation in fibroblasts from fibrostenotic Crohn's disease patients and links it to intestinal fibrosis.

A ML-framework for the discovery of next-generation IBD targets using a harmonized single-cell atlas of patient tissue

The paper develops a machine learning framework to identify cell type-specific gene targets for IBD using a harmonized single-cell atlas and validates them experimentally.

Secondary bile acid lithocholic acid ameliorates colitis-like inflammation in a human intestine-on-chip system

The paper investigates the protective effects of lithocholic acid in a human intestine-on-chip model of colitis, finding it reduces inflammation and maintains intestinal barrier integrity.

Corepressor NCoR1-mediated regulation of mucin dynamics governs gut inflammation

This study identifies NCoR1 as a regulator of goblet cell function in IBD, showing its role in mucin dynamics and disease severity through the NCoR1-KLF16 axis.

Eosinophil-derived COX-2 protects against experimental colitis through the PGE2-IL-22 axis

This study identifies eosinophil-derived COX-2 and PGE2 as critical regulators of IL-22 production during colitis, revealing a protective eosinophil-ILC3 crosstalk that safeguards the intestinal barrier.