Nerve injury and regeneration

Inositol Polyphosphate-5-phosphatase K (Inpp5k) enhances sprouting of corticospinal tract axons after CNS trauma.

This study identifies Inpp5k as a novel axon growth activator that enhances sprouting of corticospinal tract axons after CNS trauma by increasing cofilin activity and actin polymerization.

Oncomodulin derived from regeneration-associated macrophages in dorsal root ganglia after preconditioning injury promotes sensory axon regeneration in the spinal cord

Involvement of denervated midbrain-derived factors in the formation of ectopic cortico-mesencephalicprojection after hemispherectomy

This study identifies midbrain-derived glial factors upregulated after hemispherectomy that promote ectopic cortico-mesencephalic axonal projections.

Nerve recovery from treatment with a vascularized nerve graft compared to an autologous non-vascularized nerve graft in animal models: a systematic review and meta-analysis

This study compares vascularized and non-vascularized nerve grafts in animal models, finding better nerve recovery in vascularized grafts but with some results being sensitive to analysis.

Demyelination induces transcriptional reprogramming in proprioceptive and Aβ rapidly adapting low-threshold-mechanoreceptor neurons.

The paper shows that Schwann cell loss causes demyelination and transcriptional reprogramming in specific sensory neurons, suggesting a non-cell autonomous response to axon-Schwann cell interaction loss.

Optical Tissue Clearing Enables Rapid, Precise and Comprehensive Assessment of Three-Dimensional Morphology in Experimental Nerve Regeneration Research

This paper applies optical tissue clearing to study nerve regeneration in rats, enabling 3D morphological analysis of nerves and their targets with high precision and speed.

The manipulation of spinal motor neuron axonal growth promotes spinal cord repair

This study shows that knocking out pten in mature spinal motor neurons enhances axonal regeneration and synaptic reconnection after spinal cord injury.

Transthyretin promotes axon growth via regulation of microtubule dynamics and tubulin acetylation

This study shows that Transthyretin (TTR) promotes axon growth by regulating microtubule dynamics and tubulin acetylation, with restoration of acetylated tubulin rescuing defects in TTR knockout mice.

Retinoic acid treatment recruits macrophages and increases axonal regeneration after optic nerve injury in the frog Rana pipiens

This study shows that retinoic acid treatment increases macrophage numbers and phagocytic activity, which enhances axonal regeneration after optic nerve injury in frogs.

Screening for axon regeneration promoting compounds with human iPSC-derived motor neurons

This study identifies compounds that promote axon regeneration using human iPSC-derived motor neurons and validates blebbistatin as a top hit in vivo.

A Biodegradable, Tacrolimus-releasing Nerve Wrap Promotes Peripheral Nerve Regeneration

This paper develops a biodegradable nerve wrap that locally delivers tacrolimus to promote axonal regeneration and functional recovery with reduced systemic drug exposure.

Double nerve transfer to a single target muscle: experimental model in the upper extremity

This paper describes a novel experimental model for double nerve transfers to a single target muscle in rats, showing successful reinnervation without functional deficits.

Extracellular histones, a new class of inhibitory molecules of CNS axonal regeneration

The paper identifies extracellular histones as new inhibitors of CNS axonal regeneration, showing they induce growth cone collapse and can be reversed by activated protein C.

Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair

This study compares the DRG microenvironment's response to peripheral and central axon injuries using single-cell profiling, identifying PPAR pathway activation in satellite glial cells as critical for peripheral regeneration.

FKBPL and FKBP8 regulate DLK degradation and neuronal responses to axon injury

This study identifies FKBPL and FKBP8 as proteins that regulate DLK stability and degradation, affecting neuronal responses to axon injury but not regeneration.

Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection

The paper identifies nicotinic acid mononucleotide (NaMN) as an allosteric inhibitor of SARM1 that promotes axonal protection by blocking NMN binding and stabilizing the inactive SARM1 conformation.

Overexpression of Reticulon 3 enhances CNS axon regeneration and functional recovery after injury

This study shows that overexpressing RTN3 promotes axon regeneration and functional recovery after CNS injury, dependent on protrudin.

Caldendrin represses neurite regeneration via a sex-dependent mechanism in sensory neurons

This study shows caldendrin inhibits neurite regeneration in dorsal root ganglion neurons, with a sex-dependent effect on Cav1 channel regulation.

Genome-wide chromatin accessibility analyses provide a map for enhancing optic nerve regeneration

The paper identifies chromatin accessible sites and transcription factors in RGCs that correlate with axon growth capacity and shows CREB overexpression promotes axon regeneration.

Dendrite regeneration in C. elegans is controlled by the RAC GTPase CED-10 and the RhoGEF TIAM-1

This study identifies CED-10 and TIAM-1 as critical regulators of dendrite regeneration in C. elegans PVD neurons, distinct from axon regeneration pathways.

A developmental stage- and Kidins220/ARMS-dependent switch in astrocyte responsiveness to brain-derived neurotrophic factor

This study shows that astrocytes switch from a kinase-based to a calcium-based response to BDNF during development, with Kidins220/ARMS modulating both pathways and regulating Kir4.1 expression.

The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation

This study identifies the Piezo-Atr-Chek1-Cdc25 pathway as an inhibitory mechanism for axon regeneration, showing that disrupting it enhances regeneration in Drosophila and mammals.

Promoting neuronal outgrowth using ridged scaffolds coated with extracellular matrix proteins.

This paper develops a novel scaffold biomaterial coated with extracellular matrix proteins to promote axonal regeneration after spinal cord injury.

N6-methyladenine DNA demethylase ALKBH1 regulates mammalian axon regeneration

This study shows ALKBH1 demethylates N6-mA in sensory neurons, promoting axon regeneration by regulating neurodevelopmental genes.

Effects of learning and escitalopram administration on serum BDNF levels, a randomised placebo-controlled trial

This study examines how associative learning and escitalopram affect serum BDNF levels in healthy humans, finding significant time effects during learning and a negative correlation between citalopram and sBDNF levels.

Axon guidance modalities in CNS regeneration revealed by quantitative proteomic analysis

The paper uses quantitative proteomic analysis to identify guidance molecules and associated factors in the adult visual system, revealing their potential role in axon guidance during CNS regeneration.

Selective axonal translation of prenylated Cdc42 mRNA isoform supports axon growth

The paper shows that prenyl-Cdc42 mRNA localizes to PNS axons and promotes axon growth through localized translation and prenylation.

Pax3 repairs a neural circuit through a program of directed axon outgrowth

This study identifies Pax3 as a key factor in promoting directed axon outgrowth and correct targeting during neural circuit repair in response to BDNF.

Promoting axon regeneration by enhancing the non-coding function of the injury-responsive coding gene Gpr151

The paper identifies a non-coding function of the injury-responsive gene Gpr151 that promotes axon regeneration through its 5UTR interacting with RNA-binding proteins.

The prion protein is not required for peripheral nerve repair after crush injury

This study shows that the prion protein is not required for sciatic nerve regeneration after crush injury in mice.