Nerve injury and regeneration

Transcytosis-mediated anterograde transport of TrkA receptors is necessary for sympathetic neuron development and function

TIR-1/SARM1 Inhibits Axon Regeneration

This study identifies TIR-1/SARM1 as a dual regulator that inhibits axon regeneration while promoting degeneration, revealing distinct pathways for each function.

A glia cell dependent mechanism at a peripheral nerve plexus critical for target-selective axon regeneration

The paper shows that Schwann cells guide axon sorting at a nerve plexus during regeneration, restoring target-specific connectivity in zebrafish.

Membrane association is required for Stmn2-mediated axon protection

This study shows that membrane association of Stmn2 is critical for axon protection, mediated by palmitoylation and tubulin interaction, and reveals a role for DLK in regulating Stathmin abundance in axons.

The Injured Sciatic Nerve Atlas (iSNAT), Insights into the Cellular and Molecular Basis of Neural Tissue Degeneration and Regeneration

The paper creates an atlas of injured sciatic nerve cells and identifies immune microenvironments and communication networks in mouse nerve regeneration.

The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila

This study shows that reducing NMN levels in Drosophila prevents axon degeneration and neurodegeneration, revealing NMN's role in axon injury and disease.

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration after peripheral nerve injury

This study shows that senescent Schwann cells, induced by aging and chronic denervation, impair axonal regeneration by reducing c-Jun expression and secreting inhibitory factors, and that eliminating these cells improves regeneration.

Transection injury differentially alters the proteome of the human sural nerve

This study identifies proteomic changes in human sural nerve after transection injury, revealing upregulated and downregulated proteins associated with regeneration and degeneration.

Glial TGFβ activity promotes axon survival in peripheral nerves

The paper identifies glial TGFβ signaling as essential for axon survival and shows its loss leads to age-dependent neurodegeneration.

VASH1/2 inhibition accelerates functional recovery of injured nerves

This study shows that inhibiting VASH1/2 with parthenolide or its prodrug DMAPT promotes axon regeneration in injured nerves across species, suggesting potential therapeutic applications for nerve injuries.

Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injury

This study shows that overexpressing eEF1A2 promotes corticospinal axon sprouting after injury by enhancing protein synthesis, mTOR signaling, and actin rearrangement.

Cytoskeletal assembly in axonal outgrowth and regeneration analyzed on the nanoscale

The paper uses STED microscopy to analyze MPS formation in axons and regenerating axons, finding faster MPS development in regenerating axons and effects of calpain inhibition.

Genetic control of neuronal activity enhances axonal growth only on permissive substrates

The paper investigates how modulating neuronal activity with opto- or chemogenetics affects axonal growth after injury, finding that growth is enhanced only on permissive substrates.

The RSK-RPS6 axis controls the preconditioning effect and induces spinal cord regeneration

This study identifies the RSK2-RPS6 axis as essential for preconditioning and regeneration in both PNS and CNS neurons, showing its role in axon growth and functional recovery.

A photo-switchable assay system for dendrite degeneration and repair in Drosophila melanogaster

This study develops a photo-switchable assay to study dendrite degeneration and repair in Drosophila, revealing that WldS and dSarm1 modulation affects dendrite recovery.

JUN Regulation of Injury-induced Enhancers in Schwann Cells

This study investigates whether injury-induced enhancers in Schwann cells are pre-programmed or activated de novo, and identifies JUN's role in regulating these enhancers to drive repair gene expression.

Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration

The paper identifies REST/NRSF as a suppressor of CNS axon regeneration using systems biology approaches and validates its role through genetic manipulations.

The MAP3Ks DLK and LZK direct diverse responses to axon damage in zebrafish peripheral neurons

This study investigates the roles of DLK and LZK in axon regeneration and sprouting in zebrafish neurons, finding context-dependent effects on different neuron types.

Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells

The paper identifies transcriptional programs that enhance survival and axon regeneration of injured retinal ganglion cells using single-cell transcriptomics and computational analysis.

Rapid presynaptic maturation in naturally regenerating axons

This study shows that presynaptic terminals in regenerating axons rapidly mature functionally after re-contact, becoming indistinguishable from controls within a week.

Genetic or transcranial magnetic stimulation of B-RAF-MEK signaling promotes CST axon sprouting and functional regeneration

Genetic or HF-rTMS activation of B-RAF-MEK signaling promotes CST axon sprouting and functional regeneration after spinal cord injury.

The canonical Wnt signaling pathway is not a promising therapeutic target for PNS regeneration enhancement

The paper investigates the role of the canonical Wnt signaling pathway in PNS regeneration and finds that manipulating it does not enhance regeneration.

Membrane-associated shortened Trk receptors promote neuroprotection and robust axon regeneration without ligands

This study introduces a system that forces membrane localization of TrkB's intracellular domain to achieve constitutive activation, enhancing neuroprotection and axon regeneration in glaucoma models.

Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs

This study identifies KHSRP as an axonal RNA-binding protein whose mRNA is locally translated after nerve injury, leading to mRNA destabilization and slowed axon regeneration.

Nitric oxide-induced tyrosine nitration of TrkB impairs BDNF signaling and restrains neuronal plasticity

This paper shows that nitric oxide nitrates TRKB receptors, impairing BDNF signaling and reducing neuronal plasticity through endocytosis and degradation.

Expression of GDNF Receptors Within Nucleus Ambiguus During Rat Development

The paper examines the expression of GDNF receptors in the nucleus ambiguus of developing rat brains and finds differential upregulation patterns across embryonic stages.

Co-targeting B-RAF and PTEN enables sensory axons to regenerate across and beyond the spinal cord injury

This study shows that co-targeting B-RAF and PTEN in adult mice enhances dorsal column axon regeneration across and beyond spinal cord injury.

MiR-182-5p regulates Nogo-A expression and promotes neurite outgrowth of hippocampal neurons in vitro

This study shows that miR-182-5p downregulates Nogo-A expression and promotes neurite outgrowth in hippocampal neurons, suggesting its potential as a therapeutic tool for CNS regeneration.

Pleiotrophin signals through ALK receptor to enhance growth of neurons in the presence of inhibitory CSPGs

This study shows that pleiotrophin (PTN) promotes neurite outgrowth in neurons exposed to inhibitory CSPG matrix via ALK receptor activation.

Revisiting Long-Distance Axon Growth Ability in the Developing Spinal Cord using a Novel Lesion Paradigm

This study investigates the developmental timing and regional specificity of long-distance axon growth in the spinal cord using a novel lesion paradigm.