Neurogenesis and neuroplasticity mechanisms

Retinal input is required for the maintenance of neuronal laminae in the ventral lateral geniculate nucleus

The paper shows that retinal inputs are necessary for maintaining laminar organization in the ventral lateral geniculate nucleus (vLGN) but not for its initial formation.

A c-opsin functions in a ciliary-marginal zone-like stem cell region of an invertebrate camera-type eye

The paper identifies neural stem cells in the adult eye of Platynereis dumerilii that express c-opsin1 and show proliferation patterns similar to vertebrate ciliary marginal zone stem cells.

Platelet-derived LPA16:0 inhibits adult neurogenesis and stress resilience in anxiety disorder

This study shows that LPA16:0, derived from platelets, reduces adult neurogenesis and stress resilience in anxiety disorders by activating LPA1 receptors.

Mitochondrial network reorganization and transient expansion during oligodendrocyte generation

The paper examines mitochondrial dynamics during oligodendrocyte generation in mouse and human cerebral cortex, finding transient expansion and depletion linked to cellular processes and aging.

Serpina1e mediates the exercise-induced enhancement of hippocampal memory

This study identifies Serpina1e as a myokine that enhances hippocampal memory through neurotrophic signaling, showing its migration from blood to brain and effects on neurogenesis and BDNF.

Role of desmoplakin in supporting neuronal activity, neurogenic processes, and emotional-related behaviors in the dentate gyrus

This study shows that desmoplakin in the dentate gyrus supports neuronal activity, adult neurogenesis, and anxiety-like behaviors by regulating gene expression and synaptic function.

Co-activation of LIN28A and CTNNB1 disturbs cortical neuronal migration and pia mater integrity

This study shows that LIN28A and CTNNB1 co-activation disrupts cortical neuronal migration and pia mater integrity, resembling Cobblestone lissencephaly.

Cell type- and layer-specific plasticity of olfactory bulb interneurons following olfactory sensory neuron ablation

This study examines how olfactory bulb interneurons change in density and morphology after olfactory sensory neuron ablation in mice, revealing cell type- and layer-specific plasticity.

Protein degradation shapes developmental tempo in mouse and human neural progenitors

The paper compares protein dynamics in mouse and human neural progenitors, finding that human NPs have longer protein half-lives and lower proteasomal activity, which influences developmental tempo.

Adult neurogenesis improves spatial information encoding in the mouse hippocampus

This study shows that adult neurogenesis in mice enhances spatial information encoding in the hippocampus during novel context exposure.

Astrocytes control quiescent NSC reactivation via GPCR signaling-mediated F-actin remodeling

This study identifies a GPCR signaling pathway in astrocytes that regulates F-actin remodeling and NSC reactivation through Mrtf nuclear translocation.

Neuron-specific partial reprogramming in the dentate gyrus impacts mouse behavior and ameliorates age-related decline in memory and learning.

This study shows that partial reprogramming of dentate gyrus neurons in mice improves memory and learning in aged animals.

Efficient Dlx2-mediated astrocyte-to-neuron conversion and inhibition of neuroinflammation by NeuroD1

This study shows Dlx2 converts astrocytes to neurons in the striatum, but induces neuroinflammation in white matter, which is suppressed by NeuroD1.

Pyramidal neurons proportionately alter the identity and survival of specific cortical interneuron subtypes

The paper shows pyramidal neurons influence the survival and identity of specific interneuron subtypes through non-synaptic mechanisms.

Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus

This study uses snRNA-seq to track the transcriptional changes in adult hippocampal neurons from birth to maturity, identifying key transcription factors and molecular switches involved in their differentiation.

The temporal refinement of Dach1 is a key step in the functional maturation of primary somatosensory neurons

The paper shows that Dach1's temporal refinement is essential for the transcriptional maturation of somatosensory neurons.

A cafeteria diet blunts effects of exercise on adult hippocampal neurogenesis but not neurogenesis-dependent behaviours in adult male rats

This study shows that a cafeteria diet reduces exercise-induced increases in hippocampal neurogenesis but not neurogenesis-dependent behaviors in male rats.

A molecularly-defined non-redundant subpopulation of OPCs controls the generation of myelinating oligodendrocytes during postnatal development.

The paper identifies a non-redundant OPC subpopulation marked by C1ql1 that is essential for myelination during postnatal development.

GENERATION OF FUNCTIONAL NEURONS FROM ADULT HUMAN MUCOSAL OLFACTORY ENSHEATHING GLIA BY DIRECT LINEAGE CONVERSION

This paper demonstrates that adult human mucosal olfactory ensheathing glia can be directly reprogrammed into neurons using NEUROD1, showing neuronal features and functionality in vivo.

Single-cell sequencing unravels the cellular diversity that shapes neuro- and gliogenesis in the fast aging killifish (N. furzeri) brain

The paper uses scRNA-seq and ISO-seq to identify cell types in the killifish telencephalon, revealing progenitor diversity and neuronal subtypes involved in neuro- and gliogenesis.

Human Accelerated Regions regulate gene networks implicated in apical-to-basal neural progenitor fate transitions

The paper identifies human accelerated regions (HARs) that regulate gene networks involved in neural progenitor fate transitions, specifically affecting apical-to-basal polarity and cortical development.

RFC1 regulates the expansion of neural progenitors in the developing zebrafish cerebellum

This study investigates RFC1's role in zebrafish cerebellar development, showing its necessity for neural progenitor genomic integrity and neurogenesis.

The RNA binding ubiquitination ligase MEX3B regulates bFGF-dependent neuronal proliferation.

This study identifies MEX3B as an RNA-binding E3 ubiquitin ligase that regulates bFGF-dependent neuronal proliferation through interactions with REST and HOTAIR.

Morphological signatures of neurogenesis and neuronal migration in hypothalamic vasopressinergic magnocellular nuclei of the adult rat

The paper reports morphological evidence of low-rate neurogenesis and migration in the adult rat AVPMNS using immunohistochemical markers.

Engrailed transcription factors direct excitatory cerebellar neuron diversity and survival

The paper identifies molecular subdomains in the medial excitatory cerebellar nucleus (eCNm) and shows that En1/2 mutations disrupt their development and survival.

Neuroepithelial depletion schedules cessation of neurogenesis in the Drosophila optic lobes

This study shows that depletion of the neuroepithelium stem cell pool determines the cessation of medulla NBs in Drosophila optic lobes, with multiple mechanisms contributing to their termination.

Traumatic brain injury modifies adult hippocampal neural stem cell fate to promote neurogenesis at the cost of astrogliogenesis.

This study shows that traumatic brain injury shifts adult hippocampal neural stem cell fate toward neurogenesis and away from astrogliogenesis, using single-cell RNA sequencing and spatial transcriptomics.

Unraveling Lineage Roadmaps and Cell Fate Determinants to Postnatal Neural Stem Cells and Ependymal cells in the Developing Ventricular Zone

This study identifies distinct cellular states and molecular mechanisms in the developing ventricular zone, revealing key regulators of neural stem cell and ependymal cell differentiation.

The proneurogenic and microglial modulatory properties of botulinum toxin in the hippocampus of aging experimental mice

This study shows botulinum toxin increases hippocampal neurogenesis and reduces microglial inflammation in aging mice.

DCX knockout ferret reveals a neurogenic mechanism in cortical development

This study examines DCX knockout ferrets to understand neurogenic mechanisms in cortical development and reveals phenotypes resembling human lissencephaly.