Neurogenesis and neuroplasticity mechanisms

Cerebellar granular neuron progenitors exit their germinative niche via Barhl1 mediated silencing of T-Cell Factor transcriptional activity

The paper shows that Barhl1 silences TCF activity to allow granule neuron progenitors to exit their niche in the upper rhombic lip.

Amyloid beta oligomers dysregulate oligodendrocyte differentiation and myelination via PKC in the zebrafish spinal cord

This study shows that amyloid beta oligomers induce early oligodendrocyte differentiation and dysregulated myelination in zebrafish spinal cords, with PKC as a key mediator.

Sustained Generation of Neurons Destined for Neocortex with Oxidative Metabolic Upregulation upon Filamin Abrogation

The paper shows that abrogating filamin in mouse models of periventricular heterotopia increases neocortical neuron generation in the V-SVZ through oxidative metabolism and vascularization.

Ire1α-Regulated mRNA Translation Rate Controls the Identity and Polarity of Upper Layer Cortical Neurons

The paper shows that Ire1α regulates mRNA translation rates, which control the identity and polarity of upper layer cortical neurons through eIF4A1 and eEF-2.

Meta-analysis: a quantitative model of adult neurogenesis in the rodent hippocampus

This paper quantitatively models the decline of adult neurogenesis in rodents across age, showing a significant reduction in new neurons' proportion in the hippocampus.

The dynamics of oligodendrocyte populations following permanent ischemia promotes long-term spontaneous remyelination of damaged area.

This study shows that oligodendrocyte dynamics after ischemia promote long-term remyelination and sensorimotor recovery in a rat model of stroke.

Genetic ablation of GABAB receptors from oligodendrocyte precursor cells protects against demyelination in the mouse spinal cord

This study shows that removing GABAB receptors from oligodendrocyte precursor cells in mice protects against demyelination in spinal cord injury models.

Direct lineage conversion of postnatal mouse cortical astrocytes to oligodendrocyte lineage cells

This study converts postnatal mouse astrocytes to oligodendrocyte lineage cells using Sox10 or Olig2, supported by single-cell RNA sequencing and computational models.

Synaptic vesicle release regulates pre-myelinating oligodendrocyte-axon interactions in a neuron subtype-specific manner

This study shows that synaptic vesicle release affects oligodendrocyte-axon interactions in a neuron subtype-specific manner in zebrafish.

Functional roles of neural aPKCs in mouse brain development and survival

This study investigates the role of aPKC paralogs in mouse brain development and survival, finding that their function is critical during a specific window of neural progenitor differentiation but less essential afterward.

Astrocytes adopt a progenitor-like migratory strategy for regeneration in adult brain

The paper shows that mature astrocytes can transform into progenitor-like cells to regenerate astrocytic networks after injury in mice.

Neuronal migration depends on blood flow in the adult brain

The paper shows blood flow promotes neuronal migration in the adult brain by enhancing ghrelin signaling, which aids in olfactory function during food-seeking behavior.

Molecular mechanisms driving divergent development of the human frontal and visual cortex during prenatal development

The paper identifies molecular differences between the frontal and visual cortex during prenatal development, showing higher gene expression for neuron growth and connectivity in the frontal cortex.

Changes in the Dopaminergic circuitry and Adult Neurogenesis linked to Reinforcement Learning in Corvids

This study shows that structural changes in neurons and adult neurogenesis in specific brain regions of house crows are linked to visual discrimination learning.

Embryonic diversification of adult neural stem cells and ependymal cells

The paper identifies molecular mechanisms driving the divergence of adult neural stem cells and ependymal cells during embryogenesis through single-cell transcriptomic analysis.

Safb1 regulates cell fate determination in adult neural stem cells by enhancing Drosha cleavage of NFIB mRNA

This study identifies Safb1 as a regulator of neuron production in adult hippocampal neural stem cells by enhancing Drosha-mediated cleavage of NFIB mRNA, preventing glial differentiation.

Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity

This study shows that oligodendrocytes regulate synchronized neural activity during development, affecting adult behavior through Purkinje cell synchrony.

Engineering fluorescent reporters in human pluripotent cells and strategies for live imaging human neurogenesis

The paper develops fluorescent reporter tools in human pluripotent stem cells to study neural development through live imaging of cell behaviors.

Arachidonic acid incorporation into phosphatidylinositol by LPLAT11/MBOAT7 ensures radial glial cell integrity in developing neocortex

This study shows that LPLAT11/MBOAT7 is essential for arachidonic acid incorporation into phosphatidylinositol, maintaining radial glial cell integrity and preventing cortical atrophy in developing neocortex.

Msx genes delineate a novel molecular map of the developing cerebellar neuroepithelium.

The paper identifies the spatiotemporal expression patterns of Msx genes in the developing cerebellar neuroepithelium and shows their distinct localization in progenitor zones.

Enhancement of spatial learning by 40 Hz visual stimulation requires parvalbumin interneuron-dependent hippocampal neurogenesis

This study shows that prolonged 40 Hz light flicker improves spatial learning and neurogenesis in the hippocampus through GABAergic parvalbumin interneuron activity.

Control of OPC proliferation and repopulation by the intellectual disability gene PAK1 under homeostatic and demyelinating conditions

This study shows that PAK1 regulates OPC proliferation and repopulation, with mutations affecting oligodendroglial development and myelination.

Neutral competition explains the clonal composition of neural organoids

The paper explains the clonal composition of neural organoids using a neutral competition model that accounts for observed lineage size variability.

Time-resolved function of cell polarity kinases PRKCZ and PRKCI in CNS myelination

This study investigates the distinct roles of PRKCZ and PRKCI in oligodendrocyte differentiation and myelination, showing non-redundant functions in early specification and later maturation stages.

Identification of Pappa and Sall3 as Gli3 direct target genes acting downstream of cilia signalling in corticogenesis

This study identifies Pappa and Sall3 as Gli3 target genes downstream of cilia signaling in corticogenesis, showing their regulation by Gli3 in the dorsal telencephalon.

Adult dorsal root ganglion glial cells exhibit neurogenic potential upon reprogramming

This study shows adult mouse DRG glial cells can dedifferentiate into neural progenitor-like cells and express neuronal and glial markers, suggesting potential for sensory circuit regeneration.

Exponential growth and neuronal yield in the vertebrate developing retina are mediated by Hedgehog signaling

The paper quantifies retinal neurogenesis dynamics, showing exponential growth and neuronal yield are regulated by Hedgehog signaling balancing differentiation and cell cycle duration.

Adolescent Seizure Impacts Oligodendrocyte Development, Neuronal-Glial Circuit Formation, and Myelination

This study shows that adolescent seizures increase oligodendrocyte progenitor proliferation, reduce mature oligodendrocyte numbers, and impair myelination and neuron-OPC connectivity.

Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons

The paper shows that mitochondrial fusion during a critical period supports synaptic plasticity and circuit integration in adult-born neurons.

Folding of the cerebellar cortex is clade-specific in form, but universal in degree

This paper shows that cerebellar folding follows a universal scaling law across species, despite clade-specific patterns, and relates this to physical principles of self-organization.