Neurogenesis and neuroplasticity mechanisms

FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult CNS

This study identifies FBXW7 as a regulator of myelin capacity and homeostasis in the adult CNS by controlling MYRF levels through ubiquitination.

Recruitment of Homodimeric Proneural Factors by Conserved CAT-CAT E-Boxes Drives Major Epigenetic Reconfiguration in Cortical Neurogenesis

The paper investigates the role of CAT-CAT E-boxes in neurogenesis, showing their association with chromatin accessibility, DNA demethylation, and evolutionary constraint through ChIP-seq, scRNA-seq, ATAC-seq, and DNA methylation data.

A minimally guided organoid model for cross-species comparisons of cerebellar development

This study develops a cerebellar organoid model to compare development across species and identifies species-specific size differences and gene expression patterns.

Oligodendrocytes use post-synaptic proteins to coordinate myelin formation on axons of distinct neurotransmitter classes

The paper shows that Gephyrin mediates selective myelination of GABAergic and glycinergic axons in zebrafish, with loss of Gephyrin altering myelin placement toward glutamatergic axons.

Epigenome profiling identifies H3K27me3 regulation of extra-cellular matrix composition in human corticogenesis

The paper identifies H3K27me3 regulation of extra-cellular matrix composition in human corticogenesis using Epi-CyTOF and cortical organoids.

A stepwise, modular design of building uniform brain assembloids representing the dynamic cellular interplay between neurons and glial cells

This paper introduces a modular approach to create uniform forebrain assembloids that mimic the mature structure and functional connectivity of the human brain.

Natural variations in maternal behaviour shape trait anxiety and hippocampal neurogenesis in offspring

This study shows that natural variations in maternal care affect anxiety and hippocampal neurogenesis in offspring, linking early life experiences to long-term brain plasticity and behavior.

Progenitor-Derived Regulatory Logic Generates Functionally Related Neuronal Subtypes

The paper identifies a regulatory logic in progenitors that generates functionally related neuronal subtypes, showing its conservation across species.

Astrocyte-derived PEA116 increases adult hippocampal neurogenesis and confers stress resilience

This study identifies PEA116, an astrocyte-derived peptide that enhances adult hippocampal neurogenesis and stress resilience by promoting aNSC proliferation through ERK2 phosphorylation.

Transcriptomic Changes in Oligodendrocyte Lineage Cells During the Juvenile to Adult Transition in the Mouse Corpus Callosum

The paper identifies age-related gene expression changes in oligodendrocyte lineage cells in the mouse corpus callosum using RNA-seq data from different ages.

Brain-derived neurotrophic factor and adenosine A2A receptor interaction modulates oligodendrogenesis derived from postnatal SVZ neural stem cells

This study shows BDNF enhances oligodendrogenesis from SVZ-NSCs, with A2AR antagonism blocking this effect, suggesting their interaction modulates differentiation.

Quantitative in toto live imaging analysis of apical nuclear migration in the mouse telencephalic neuroepithelium

The paper quantitatively analyzes apical nuclear migration in the mouse telencephalic neuroepithelium using in toto live imaging, revealing decreased velocity and increased nuclear density over time.

A stolen future: aberrant hippocampal neurogenesis produces glial cells in epilepsy

The paper investigates how epilepsy causes early neuroblasts to switch fate to astrocytes in both mouse and human tissue using immunolabelling and single-cell RNA sequencing.

Natural variations of adult neurogenesis and anxiety predict hierarchical status of inbred mice

The paper shows that natural variations in adult hippocampal neurogenesis and anxiety predict social dominance in inbred mice, suggesting a regulatory role of neurogenesis in hierarchical behavior.

Evidence that Dmrta2 acts as a transcriptional repressor of Pax6 in murine cortical progenitors and identification of a mutation crucial for DNA recognition associated with microcephaly in human

This study shows Dmrta2 represses Pax6 in cortical progenitors and identifies a DNA-binding mutation linked to microcephaly in humans.

Dynamic spatiotemporal activation of a pervasive neurogenic competence in striatal astrocytes supports continuous neurogenesis following injury

The paper shows that striatal astrocytes have widespread neurogenic potential that is activated focally after injury, with behavior similar to canonical niches.

Developmental emergence of first- and higher-order thalamic neuron molecular identities

The paper shows that first-order thalamic neurons develop from higher-order neurons with peripheral input driving excitatory neuron maturation.

Embryonic origins of forebrain oligodendrocytes revisited by combinatorial genetic fate mapping

The paper revisits the embryonic origins of forebrain oligodendrocytes using genetic fate mapping, finding that LGE/CGE-derived OLs dominate specific brain regions while MGE/POA-derived OLs contribute uniquely to the cortex.

The Lateral/Caudal Ganglionic Eminence Makes a Limited Contribution to Cortical Oligodendrocytes

This study challenges the belief that lateral/caudal ganglionic eminence contributes significantly to cortical oligodendrocyte progenitor cells, showing instead that its contribution is minimal.

Effect of Alcohol and Cocaine Abuse on Neuronal and Non-Neuronal Cell Turnover in the Adult Human Hippocampus

The paper assesses neuronal and non-neuronal cell turnover in the hippocampus of individuals with alcohol or cocaine abuse compared to healthy controls, finding no significant difference in turnover rates between groups.

Acute dietary methionine restriction highlights sensitivity of neocortex development to metabolic variations

This study shows that acute methionine restriction during mouse neocortex development severely reduces growth and neuronal production, but this effect is reversible with dietary recovery.

Stab Wound Injury Elicits Transit Amplifying Progenitor-like Phenotype in Parenchymal Astrocytes

This study identifies injury-induced plastic astrocytes in mice that exhibit self-renewal and neurosphere-forming capabilities, resembling transit-amplifying progenitors in transcriptional profile.

Brain-wide mapping of oligodendrocyte organization and oligodendrogenesis across the murine lifespan

The paper maps oligodendrocyte organization and dynamics across the mouse lifespan, revealing age- and region-specific differences in oligodendrogenesis and resilience.

Single-cell triple-omics uncovers DNA methylation as key feature of stemness in the healthy and ischemic adult brain

The paper uses single-cell triple-omics to show DNA methylation patterns are key to stemness in adult brain cells, especially under ischemic conditions.

Loss of prohibitin 2 in Schwann cells dysregulates key transcription factors controlling developmental myelination

This study shows that loss of Phb2 in Schwann cells disrupts myelination and dysregulates key transcription factors essential for peripheral nerve development.

Neuregulin1 nuclear signaling influences adult neurogenesis and regulates a schizophrenia susceptibility gene network within the mouse dentate gyrus.

This study shows that a schizophrenia-associated Nrg1 mutation disrupts nuclear signaling in mouse dentate gyrus, altering gene expression and neurodevelopmental processes.

Age Dependent Integration of Cortical Progenitors Transplanted at the Adult CSF-Brain Interface

This study transplants rat cortical progenitors into adult rat brains to create brain-like tissues and assesses their integration and connectivity across different host ages.

Estrogens dynamically regulate neurogenesis in the dentate gyrus of adult female rats

This study shows estradiol and estrone differentially affect neurogenesis in adult female rats' dentate gyrus, with short-term effects but not long-term.

Adolescent oligodendrogenesis and myelination restrict experience-dependent neuronal plasticity in adult visual cortex

This study shows that preventing oligodendrocyte maturation during adolescence reduces myelination and preserves experience-dependent plasticity in adult visual cortex.

Pregnancy History and Estradiol Influence Spatial Memory, Hippocampal Plasticity, and Inflammation in Middle-aged Rats

This study examines how maternal age at first pregnancy and estradiol treatment affect hippocampal neuroplasticity, inflammation, and spatial memory in middle-aged rats.