Retinal Development and Disorders

Differential impact of Kv8.2 loss on rod and cone signaling and degeneration.

This study examines the impact of Kv8.2 loss on rod and cone photoreceptor signaling and degeneration using a knockout mouse model.

Early mitochondrial stress and metabolic imbalance lead to photoreceptor cell death in retinal degeneration

This study identifies early mitochondrial stress and metabolic imbalances as key drivers of photoreceptor cell death in retinal degeneration using a multi-omics approach in a mouse model.

Development and retinal remodeling in the brown anole lizard (Anolis sagrei)

This paper describes retinal development and remodeling in the brown anole lizard, identifying key features of fovea formation and its relationship to eye shape changes.

Inflammation modulates regeneration in the acute or chronically damaged zebrafish retina

This study investigates how inflammation affects retinal regeneration in zebrafish following acute or chronic damage, showing differential microglia responses and cytokine gene expression.

Stretching of the retinal pigment epithelium contributes to zebrafish optic cup morphogenesis

This study shows that zebrafish RPE cells stretch to match retinal curvature during optic cup formation, with proliferation and cytoskeletal interference affecting this process.

Genetic Interplay Between Transcription Factor Pou4f1/Brn3a and Neurotrophin Receptor Ret In Retinal Ganglion Cell Type Specification

This study shows that Brn3a and Ret interact in retinal ganglion cell type specification, with Brn3a loss affecting Ret co-receptors and neurotrophin receptors.

Human primitive mesenchymal stem cell-derived retinal progenitor cells promoted neuroprotection and neurogenesis in rd12 mice

This study shows that human retinal progenitor cells derived from primitive mesenchymal stem cells improve retinal function and structure in a mouse model of retinal degeneration.

Short-term assessment of subfoveal injection of AAV2-hCHM gene augmentation in choroideremia using adaptive optics ophthalmoscopy

The paper assesses the short-term effects of AAV2-hCHM gene injections on cone mosaic integrity in CHM patients using AOSLO and finds preservation of the mosaic with minor foveal thinning.

RPE65-related retinal dystrophy: mutational and phenotypic spectrum in 45 affected patients.

The paper analyzes RPE65 variants in 45 patients with retinal dystrophy, finding associations between variant types and age at onset.

Widespread translational control regulates retinal development in mouse

This study identifies widespread translational regulation during mouse retinal development, revealing dynamic translational changes and novel micropeptides involved in retinal function.

Glycogen Synthase Kinase 3 regulates the genesis of the rare displaced ganglion cell retinal subtype

This study shows that GSK3 signaling regulates the genesis of displaced ganglion cells in the retina, with loss of GSK3 leading to increased numbers of these cells and altered axon projections.

Functional microRNA targetome undergoes degeneration-induced shift in the retina

The paper identifies a shift in the active miRNA targetome in a mouse model of retinal degeneration, showing changes in miRNA binding regions and AGO2 localization.

Critical period for vision-dependent modulation of postnatal retinal neurogenesis

This study shows that postnatal retinal neurogenesis in mice is modulated by visual experience during a critical period ending around postnatal day 70.

Extensive incorporation, polarisation and improved maturation of transplanted human cones in a murine cone degeneration model

This paper demonstrates that transplanted human photoreceptors from iPSC retinal organoids extensively incorporate into a murine cone degeneration model, leading to improved maturation, polarisation, and functional integration.

Notch signaling via Hey1 and Id2b regulates Muller glia's regenerative response to retinal injury

The paper identifies Notch signaling components that regulate Muller glia's regenerative response to retinal injury by modulating injury-response threshold and progenitor proliferation.

Seeing Nemo: molecular evolution of ultraviolet visual opsins and spectral tuning of photoreceptors in anemonefishes (Amphiprioninae)

The paper investigates the molecular evolution of UV-sensitive opsins in anemonefishes, identifying gene duplications and expression patterns that contribute to UV vision.

Arap1 Loss Causes RPE Phagocytic Dysfunction and Subsequent Photoreceptor Death

This study shows that Arap1 in retinal pigment epithelium (RPE) is essential for photoreceptor survival through its role in phagocytosis, as Arap1 deficiency leads to photoreceptor degeneration.

Retinal degeneration: Multilevel protection of photoreceptor and ganglion cell viability and function with the novel PKG inhibitor CN238.

This study identifies CN238, a novel PKG inhibitor, as a neuroprotective agent that preserves photoreceptor and ganglion cell viability and function in retinal degeneration models.

Deficiency in Lyst function leads to accumulation of secreted proteases and predisposition to mechanic stress-induced retinal detachment

This study shows that Lyst deficiency in mice leads to retinal detachment by causing phagosome accumulation and increased proteases in retinal pigment epithelial cells.

Genetically engineered retina for improved retinal reconstruction after transplantation

This study shows genetically engineered retinal sheets improve visual recovery by enhancing neural integration and reducing aberrant activity after transplantation in mice.

Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states

This study identifies the role of Notch signaling in repressing cone photoreceptor formation by maintaining multipotent retinal progenitor cells and preventing their transition to restricted progenitor cells.

Augmentation of CD47-SIRPα signaling protects cones in genetic models of retinal degeneration

This study shows that enhancing CD47-SIRPα signaling protects cones in retinal degeneration models by promoting survival and preserving vision.

Large-scale Phenotypic Drug Screen Identifies Neuroprotectants in Zebrafish and Mouse Models of Retinitis Pigmentosa

The paper identifies neuroprotective compounds for retinitis pigmentosa using cross-species drug screens in zebrafish and mouse models, finding additive effects in some combinations.

Early onset non-syndromic retinal degeneration due to variants in INPP5E: phenotypic expansion of the ciliary gene previously associated with Joubert syndrome

The paper identifies INPP5E variants in non-syndromic retinal degenerations, expanding the known phenotypic spectrum of this ciliary gene.

Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish

The paper analyzes gene network bifurcation during optic cup morphogenesis in zebrafish, identifying regulatory mechanisms and conserved TF recruitment sequences in RPE specification.

Potential therapy for progressive vision loss due to PCDH15-associated Usher syndrome developed in an orthologous Usher mouse

The paper describes a potential therapy for PCDH15-associated Usher syndrome using exogenous retinoids in a mouse model, showing improved ERG amplitudes.

Treadmill exercise promotes retinal astrocyte plasticity and protects against retinal degeneration

This paper shows treadmill exercise increases retinal astrocyte complexity and BDNF interactions, protecting against light-induced retinal degeneration.

A high-density narrow-field inhibitory retinal interneuron with direct coupling to Müller glia

The paper identifies a new inhibitory retinal amacrine cell type, MAC, that forms direct electrical and chemical synapses with Müller glia, revealing neuron-glia coupling in the mammalian retina.

Drug Screening with Zebrafish Visual Behavior Identifies Carvedilol as a Potential Treatment for Retinitis Pigmentosa

This study screens drugs using zebrafish visual behavior to identify carvedilol as a potential treatment for retinitis pigmentosa.

Transcriptome profiling of embryonic retinal pigment epithelium reprogramming

This study identifies FGF2-driven gene expression changes in embryonic chicken RPE reprogramming, highlighting MAPK signaling and EMT processes.