Retinal Development and Disorders

A high-density narrow-field inhibitory retinal interneuron with direct coupling to Müller glia

The paper identifies a new inhibitory retinal amacrine cell type, MAC, that forms direct electrical and chemical synapses with Müller glia, revealing neuron-glia coupling in the mammalian retina.

Drug Screening with Zebrafish Visual Behavior Identifies Carvedilol as a Potential Treatment for Retinitis Pigmentosa

This study screens drugs using zebrafish visual behavior to identify carvedilol as a potential treatment for retinitis pigmentosa.

Transcriptome profiling of embryonic retinal pigment epithelium reprogramming

This study identifies FGF2-driven gene expression changes in embryonic chicken RPE reprogramming, highlighting MAPK signaling and EMT processes.

Retinal and cortical visual acuity in a common inbred albino mouse.

This study compares retinal and cortical visual acuity between albino and pigmented mice using electrophysiological methods, finding lower acuity in albino mice primarily due to retinal factors.

Subcellular localization of PKA catalytic subunits provides a basis for their distinct functions in the retina

The paper maps the subcellular localization of PKA subunits in the retina, revealing distinct patterns and functional nonredundancy, with C{beta} localized to mitochondria and linked to neurodegenerative diseases.

Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance

This study shows NPHP1 is needed to keep inner segment proteins in place during photoreceptor development but not after outer segments mature.

Otx2 and Oc1 directly regulate the transcriptional program of cone photoreceptor development

The paper identifies cis-regulatory modules regulated by Otx2 and Oc1 in cone photoreceptor development and shows Otx2 autoregulation.

Antisense oligonucleotide-based treatment of retinitis pigmentosa caused by USH2A exon 13 mutations

This study demonstrates that QR-421a induces exon 13 skipping in USH2A transcripts, restoring retinal function in zebrafish and non-human primates.

Ccr2 suppression by minocycline in Cx3cr1/Ccr2-visualized inherited retinal degeneration

This study shows minocycline suppresses Ccr2 expression and ameliorates retinal degeneration in a mouse model.

Ocular elongation and retraction in foveated reptiles

The paper examines ocular shape changes during development in two foveated reptiles, finding asymmetric elongation and retraction linked to fovea formation and photoreceptor packing.

Plagl1 is part of the mammalian retinal injury response and a critical regulator of Muller glial cell quiescence

The paper identifies Plagl1 as a regulator of Muller glial quiescence in the mammalian retina, showing its role in preventing reactive gliosis and neurogenesis after injury.

Eye morphogenesis in the blind Mexican cavefish

The paper identifies defects in cell migration during eye development in blind Mexican cavefish leading to coloboma.

Regulation of neurogenesis and gliogenesis by the matricellular protein CCN2 in the mouse retina

This study shows that CCN2 regulates retinal progenitor cell proliferation and differentiation through the YAP pathway, affecting neurogenesis and gliogenesis in the mouse retina.

Spatiotemporal specification of human green and red cones

The paper investigates the spatiotemporal development of M and L cones in the human retina, finding that retinoic acid signaling promotes M cone fate early in development.

Gene Therapy Reforms Photoreceptor Structure and Restores Vision in NPHP5-associated Leber Congenital Amaurosis

This paper demonstrates that gene therapy using AAV-mediated NPHP5 augmentation restores photoreceptor structure and function in a canine model of Leber congenital amaurosis.

Early cis-regulatory events in the formation of retinal horizontal cells

This study identifies cis-regulatory elements that regulate horizontal cell development by analyzing enhancer activity and transcription factor interactions.

Altered visual function in a larval zebrafish knockout of neurodevelopmental risk gene pdzk1

This study investigates the role of pdzk1 in visual function using zebrafish knockouts, finding altered optomotor responses and ERG b-waves without major retinal structural changes.

Igf signalling uncouples retina growth from body size by modulating progenitor cell division

The paper shows that Igf1 receptor signaling in the ciliary marginal zone controls retinal growth independently of body size in medaka fish.

Atoh7-independent specification of retinal ganglion cell identity

This study shows that Atoh7 is essential for RGC survival but not for their specification, as RGCs can develop without Atoh7 when apoptosis is inhibited.

Expression and protein sequence analyses of zebrafish impg2a and impg2b, two proteoglycans of the interphotoreceptor matrix

The paper studies zebrafish impg2a and impg2b proteoglycans, their expression patterns, and structural conservation to model IMPG2-related retinal diseases.

Transplanted pluripotent stem cell-derived photoreceptor precursors elicit conventional and unusual light responses in mice with advanced retinal degeneration

This study shows that transplanted pluripotent stem cell-derived cone precursors can restore light responses in mice with advanced retinal degeneration, despite low engraftment.

Single cell transcriptomics reveals lineage trajectory of the retinal ganglion cells in wild-type and Atoh7-null retinas

The paper uses single-cell RNA-seq to analyze retinal ganglion cell lineage development in wild-type and Atoh7-null retinas, revealing a transitional cell state and revised understanding of Atoh7's role.

Genomic and Spectral Visual Adaptation in Southern Leopard Frogs during the Ontogenetic Transition from Aquatic to Terrestrial Light Environments

The paper identifies gene expression differences in frog eyes during the transition from aquatic to terrestrial environments and confirms adaptive changes in spectral sensitivity.

Cone mitochondria act as microlenses to enhance light delivery and confer Stiles-Crawford-like direction sensitivity

This study shows cone mitochondria act as microlenses to focus light into the cone outer segment, producing an angular light intensity effect similar to the Stiles-Crawford effect.

Midkine in chick and mouse retinas: neuroprotection, glial reactivity and the formation of Müller glia-derived progenitor cells

This study investigates MDK's role in retinal development and regeneration in chick and mouse, showing its impact on neuronal survival, glial reactivity, and Müller glia-derived progenitor cell formation.

Bidirectional neuronal migration coordinates retinal morphogenesis bypreventing spatial competition

The paper shows bidirectional neuronal migration prevents spatial competition during retinal morphogenesis in zebrafish, human tissue, and organoids.

Molecular profiling of retinal pigment epithelial cell differentiation for therapeutic use

This study maps the single-cell transcriptomic dynamics of hESC-RPE differentiation, identifies an intermediate progenitor, and shows in vivo maturation after transplantation.

Therapeutic adenine base editing corrects nonsense mutation and improves visual function in a mouse model of Leber congenital amaurosis

This study uses adenine base editing to correct a nonsense mutation in a mouse model of LCA, improving visual function.

Deletion of INPP5E in the murine retina impairs axoneme formation and prevents photoreceptor disc morphogenesis

Structural engraftment and topographic spacing of transplanted human stem cell-derived retinal ganglion cells

This study investigates how transplanted human stem cell-derived retinal ganglion cells integrate into the host retina and identifies the internal limiting membrane as a barrier to structural integration.