Hippo pathway signaling and YAP/TAZ

YAP1 Regulates the Self-organized Fate Patterning of hESCs-Derived Gastruloids

This study shows YAP1 is essential for proper germ layer patterning in hESCs-derived gastruloids by regulating NODAL signaling and repressing mesoendodermal differentiation.

Yorkie-independent negative feedback couples Hippo pathway activation with Kibra degradation

The paper shows the Hippo pathway downregulates Kibra levels through SCFSlimb-mediated ubiquitination, independent of Yorkie, to control tissue growth.

The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

This study identifies the Hippo pathway's role in regulating sarcomeric gene expression to control myofibril assembly and muscle fiber growth in Drosophila.

Modulation of Yorkie activity by alternative splicing is required for developmental stability

This study shows that alternative splicing of yorkie is essential for developmental stability in Drosophila by modulating Yki protein function and reducing developmental noise.

Autonomous termination of proliferation in the Drosophila wing disc is TORC1 dependent

The paper shows that proliferation termination in Drosophila wing discs occurs due to reduced TORC1 activity, independent of Dpp or Hippo/Yorkie signaling.

Maternal vgll4a promotes blastoderm cohesion enabling yap1-mediated mechano-transduction during zebrafish epiboly

This study shows that maternal vgll4a coordinates blastomere adhesion and cohesion during zebrafish epiboly, enabling Yap1-mediated mechano-transduction.

Syd/JIP3 Controls Tissue Size by Regulating Diap1 Protein Turnover Downstream of Yorkie/YAP

This study identifies Syd/JIP3 as a regulator of tissue size by controlling Diap1 protein turnover downstream of Yorkie/YAP, showing conservation between Drosophila and mammalian cells.

Topology-driven protein-protein interaction network analysis detects genetic sub-networks regulating reproductive capacity

The paper uses network analysis to identify genetic sub-networks regulating reproductive capacity in Drosophila by integrating functional genetic data with protein-protein interactions.

YAP and TAZ promote periosteal osteoblast precursor expansion and differentiation for fracture repair

This study shows YAP and TAZ promote periosteal osteoblast precursor expansion and differentiation to accelerate bone fracture healing.

Yap haploinsufficiency leads to Müller cell dysfunction and late-onset cone dystrophy

This study investigates Yap haploinsufficiency in mice, revealing its role in Müller glia dysfunction and late-onset cone dystrophy in aged individuals.

Genome-wide RNAi screen for context-dependent tumor suppressors identified using in vivo models for neoplasia in Drosophila

The paper identifies tumor suppressor genes interacting with EGFR and Yki in Drosophila using RNAi screens and finds novel connections to growth regulation.

Multiplexed quantitative screens of single cell shape and YAP/TAZ localisation identify DOCK5 as a coincident detector of polarity and adhesion during migration.

The paper identifies DOCK5 as a regulator of YAP/TAZ localization and cell shape during migration, showing its role in maintaining polarity through interactions with CDC42, RAC, and RHOA.

Twist regulates Yorkie to guide lineage reprogramming of syncytial alary muscles

This study shows that Twist regulates Yorkie to enable lineage reprogramming of syncytial alary muscles in Drosophila.

Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP signaling pathway in the remodeling of blood vessels

This study identifies thrombospondin-1 as a mediator of matrix mechanotransduction in vascular remodeling, showing its role in integrin signaling and YAP nuclear shuttling under mechanical stress.

Pits and CtBP control tissue growth in Drosophila melanogaster with the Hippo pathway transcription repressor, Tgi.

This study identifies Pits and CtBP as Tgi-interacting proteins that cooperate in transcriptional repression of Hippo pathway target genes in Drosophila, with conservation in human orthologs.

Hippo signaling promotes Ets21c-dependent apical cell extrusion in the Drosophila wing disc

This study identifies Hippo signaling's role in inducing apical and basal cell extrusion in Drosophila wing discs, with Ets21c mediating apical extrusion and bantam mediating basal extrusion.

Position-sensing established duringcompaction dictates cell fate in themammalian embryo

The paper shows that blastomere position during early embryogenesis influences YAP localization through apicobasal polarity and PKC signaling, affecting cell fate decisions.

Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import, stability and phase separation.

The transcriptional co-repressor CtBP is a negative regulator of growth that antagonizes the Yorkie and JNK/AP-1 pathways

The paper identifies CtBP as a negative regulator of growth that antagonizes Yorkie and JNK/AP-1 pathways by restricting bantam microRNA expression.

Yorkie controls tube length and apical barrier integrity in the developing Drosophila airways

This paper identifies Yorkie's dual role in regulating tracheal tube length and apical barrier integrity in Drosophila airways through cytoplasmic and transcriptional mechanisms.

YAP/TAZ-TEAD Activity Links Mechanical Cues To Cell Progenitor Behavior During Hindbrain Segmentation

The paper shows that Yap/Taz-TEAD activity mediates mechanical signal sensing in hindbrain boundary cells, linking mechanical cues to progenitor behavior and cell fate changes.

Epiblast formation by Tead-Yap-dependent expression of pluripotency factors and competitive elimination of unspecified cells

The paper identifies Tead-Yap regulation of pluripotency factors and cell competition in epiblast formation, showing Tead activity drives pluripotency and eliminates unspecified cells.

Metabolic control of YAP via the acto-myosin system during liver regeneration

The paper investigates how the acto-myosin system regulates YAP activity during liver regeneration in response to bile acid overload.

Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

This study shows that the LATS/YAP/TAZ pathway regulates SOX2+ pituitary stem cells, controlling their homeostasis and tumourigenic potential during development and in adulthood.

Deletion of Lats 1 and 2 in mouse pancreatic acinar cells induces pancreatic fibrosis and inflammation

This study shows that deleting Lats1 and Lats2 in adult mouse pancreatic acinar cells causes fibrosis and inflammation through YAP1/TAZ activation.

Loss of YAP/TAZ impaired the proliferation and differentiation ability of neural progenitor cells

This study shows that YAP/TAZ deletion in mouse neural progenitor cells causes hydrocephalus, disrupts cell polarity, increases cell cycle exit, and reduces differentiation into Tbr2+ cells.

HIPPO signaling resolves embryonic cell fate conflicts during establishment of pluripotency in vivo

The paper shows HIPPO signaling resolves cell fate conflicts by repositioning cells during pluripotency establishment in the mouse embryo.

Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis

This study identifies Shavenbaby as a novel Hippo pathway effector critical for adult stem cell survival by activating DIAP1 to prevent apoptosis in Drosophila renal stem cells.

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth

This study shows Yap regulates glucose utilization and nucleotide synthesis to support organ growth in zebrafish, with conserved mechanisms in mammals.

Micromanagment of stem cell proliferation by the Drosophila testis stem cell niche

The paper shows the Drosophila testis niche controls stem cell proliferation by repressing Hippo pathway genes without involving a binary fate decision between stemness and differentiation.