C. Yu

A mitochondrial long-chain fatty acid oxidation defect leads to uncharged tRNA accumulation and activation of the integrated stress response in the mouse heart

Identification and characterization of the HERV-K (HML-8) group of human endogenous retroviruses in the genome

This study characterizes the HERV-K (HML-8) group in the human genome, identifying 40 proviruses and 5 solo LTR elements and determining their integration time and genomic distribution.

Improving Lab Culture Through Self-Assessment: A Case Study

The paper describes a self-assessment process to improve lab culture through surveys and group discussions, resulting in a 12% increase in member satisfaction.

Elevated transcriptional pausing of RNA polymerase II underlies acquired resistance to radiotherapy

This study identifies increased RNA polymerase II pausing as a mechanism of acquired radiotherapy resistance in cancer cells and suggests CDK7 inhibitors as a potential therapeutic strategy.

Mice with a humanized immune system are resilient to transplantation of human microbiota

This study shows that humanized mice with engrafted human immune cells can resist human gut microbes, but microbial communities differ from those in non-humanized mice.

Bone-Specific Enhancement of Antibody Therapy for Breast Cancer Metastasis to Bone

This paper enhances antibody therapy for breast cancer bone metastasis by engineering antibodies with bone-homing peptides, improving their bone tumor targeting and therapeutic efficacy.

Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

This study shows UCH37 deubiquitinates branched ubiquitin chains, enhancing proteasome clearance of stress-induced inclusions.

COVID-ONE-humoral immune: The One-stop Database for COVID-19-specific Antibody Responses and Clinical Parameters

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

B Cell Receptor Signaling Drives APOBEC3 Expression Via Direct Enhancer Regulation in Chronic Lymphocytic Leukemia B Cells

This study shows BTKi treatment reduces APOBEC3 expression in CLL B cells through enhancer regulation, linking BCR signaling to genomic instability.

The peroxisomal transporter ABCD3 plays a major role in dicarboxylic fatty acid metabolism

This study investigates the role of ABCD3 in DCA metabolism using an Abcd3 KO mouse model and shows its impact on lipid homeostasis and metabolic compartmentalization.

Multiple levels of triggered factors and positive effect of cell-to-cell bottleneck in mutation repair of RNA viruses

This study identifies multiple triggering factors for mutation repair in RNA viruses and shows that cell-to-cell movement enhances mutation repair, opposing the Muller ratchet effect.

ARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-dependent transcription

This study shows ARID1A loss activates HERVH, which promotes tumor growth by modulating BRD4-dependent transcription in colorectal cancer.

Endogenous RNA editing of a nuclear gene BOSS triggers flowering in tomato

The paper identifies RNA editing of the BOSS gene in tomato that regulates flowering by producing functionally distinct transcripts.

Dynamics and heterogeneity of Erk-induced immediate-early gene expression

The paper quantifies how Erk signaling dynamics influence immediate-early gene expression in cells and shows that response heterogeneity is not fully explained by Erk activity.

A novel type of IRES having variable numbers of eIF4E-binding site and synergistic effect in RNA2 of WYMV isolates

The paper identifies a novel IRES in WYMV RNA2 with variable eIF4E-binding sites and synergistic effects that enhance IRES activity.

Ras guanine nucleotide exchange factor RasGRP1 promotes acute inflammatory response and restricts inflammation-contributed cancer cell growth

This study identifies RasGRP1 as a bifunctional regulator that promotes acute inflammation and inhibits inflammation-associated cancer growth.

Murine deficiency of peroxisomal L-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis

This study investigates the role of EHHADH in DCA β-oxidation and its impact on hepatic cholesterol homeostasis in mice, finding that EHHADH deficiency leads to 3-hydroxydicarboxylic aciduria and altered cholesterol synthesis.

Harnessing the Power of Antibodies to Fight Bone Metastasis

This paper develops a bone-targeting antibody using bisphosphonate conjugation and demonstrates its enhanced efficacy against bone metastases in xenograft models.

On the robustness of inference of association with the gut microbiota in stool, swab and mucosal tissue samples

This study compares the robustness of microbiota association inference using stool, swab, and mucosal tissue samples in a larger cohort, finding that mucosal samples yield less consistent results than stool or swab.

Simple and Rapid High-Throughput Assay to Identify HSV-1 ICP0 Transactivation Inhibitors

This paper develops a high-throughput assay to identify inhibitors of HSV-1 ICP0 transactivation, identifying 76 potential inhibitors from 19,000 compounds.

Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19

The paper examines sex differences in MAIT cell responses in COVID-19 patients, finding reduced circulating MAIT cells in females and a protective gene signature associated with female MAIT cells.

Glutaric aciduria type 3 is a naturally occurring biochemical trait in inbred mice of 129 substrains

The paper identifies glutaric aciduria type 3 as a naturally occurring trait in 129 substrain mice due to SUGCT deficiency, showing its impact on metabolite accumulation.

Clinically applicable histopathological diagnosis system for gastric cancer detection using deep learning

This paper develops a deep learning system for gastric cancer detection using histopathological images, achieving high sensitivity and robust performance across different scanners.

Modulation of Siglec-7 Signaling via in situ Created High-affinity cis-Ligands

The paper shows that modulating Siglec-7 signaling via high-affinity cis-ligands on NK cells can suppress or enhance NK cytotoxicity depending on ligand concentration.

A potent neutralizing human antibody reveals the N-terminal domain of the Spike protein of SARS-CoV-2 as a site of vulnerability

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

Glycoengineering of NK cells with glycan ligands of CD22 and selectins for B-cell lymphoma therapy

This study modifies NK cells with CD22 and selectin glycan ligands to enhance B-cell lymphoma targeting and trafficking, achieving effective tumor suppression in a xenograft model.

Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex

This study identifies DHTKD1 inhibitors and reports its crystal structure with thiamin diphosphate, revealing how mutations affect its function and stability.

hFUT1-based live cell assay to profile α1-2-fucosides enhanced influenza A virus infection

This study develops a live cell assay using hFUT1 to profile α1-2-fucosides' role in enhancing influenza A virus infection.

Changes in ambient temperature are the prevailing cue in determining Brachypodium distachyon diurnal gene regulation

This study identifies thermocycles as the primary cue for diurnal gene regulation in Brachypodium distachyon, showing that most rhythmic transcripts adjust their period in constant conditions.

Lipid-mediated insertion of Toll-like receptor (TLR) ligands for facile immune cell engineering

This paper introduces lipid-mediated insertion of TLR ligands as a non-genetic method to engineer immune cells, showing controlled delivery and persistent activation without permanent genetic modification.