B. Lee

A unified view of low complexity regions (LCRs) across species

This paper defines LCR type/copy relationships and creates a map of LCR sequence space to uncover their role in higher order assemblies across species.

The colonial legacy of herbaria

The paper analyzes 85 million herbarium records to show colonial legacies in plant specimen distribution, revealing disparities between biodiversity hotspots and where specimens are housed.

Single-cell sequencing unveils distinct immune microenvironment with CCR6-CCL20 crosstalk in human chronic pancreatitis

This study uses single-cell sequencing to identify distinct immune features and CCR6-CCL20 crosstalk in hereditary versus idiopathic chronic pancreatitis.

Taxonomic classification methods reveal a new subgenus in the paramyxovirus subfamily Orthoparamyxovirinae

The paper uses taxonomic classification methods to identify a new subgenus in the Orthoparamyxovirinae subfamily based on viral genome sequences from bats.

Nipah virus Bangladesh infection elicits organ-specific innate and inflammatory responses in the marmoset model

This study investigates NiV Bangladesh infection in marmosets, revealing organ-specific innate and inflammatory responses through RNA-seq analysis.

Molecular assembly of measles and Nipah virus: specific lipid binding drives conformational change and matrix polymerization

This study identifies how measles and Nipah virus M proteins bind specific lipids, inducing conformational changes that drive virion assembly.

Assessing the zoonotic potential of a novel bat morbillivirus

This study identifies a novel bat morbillivirus, MBaMV, and assesses its zoonotic potential by showing it can infect human cells but is restricted by human immune responses.

NLRP3 activation in response to disrupted endocytic traffic

This study shows NLRP3 detects disrupted endosome trafficking, leading to inflammasome activation and cytokine release in macrophages.

TOR signalling is required for host lipid metabolic remodelling and survival following enteric infection in Drosophila

This study identifies TOR signalling as critical for lipid metabolic remodelling and survival in Drosophila during enteric infection.

Proteogenomics Reveals how Metastatic Melanoma Modulates the Immune System to Allow Immune Evasion

This paper analyzes proteogenomic data from melanoma patients to show how metastatic melanoma alters metabolism and immune responses to evade immune detection.

GPR15 in colon cancer development and anti-tumor immune responses.

This study investigates the role of GPR15 in colon cancer, showing its deficiency promotes tumor growth by altering immune responses, and identifies GPR15L as a potential therapeutic target.

Data-driven analysis of COVID-19 reveals specific severity patterns distinct from the temporal immune response

The paper identifies immune signatures associated with COVID-19 severity and temporality, revealing distinct patterns and providing tools for data analysis.

Transcriptome profiling of human pluripotent stem cell-derived cerebellar organoids reveals fastercommitment under dynamic conditions

This study shows that dynamic differentiation using Vertical-Wheel bioreactors produces cerebellar organoids with faster commitment and enriched extracellular matrix, improving their neural microenvironment and functional maturation.

Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypes

The paper identifies hyperfusogenic measles virus F protein mutants associated with neuropathogenic phenotypes through a saturating mutagenesis screen.

Donor-Specific Plasma Factors Contribute to Aberrant Staining Artifacts with a Commercial Lyophilized Mass Cytometry Antibody Panel

The paper identifies donor-specific plasma factors causing aberrant staining in a commercial CyTOF antibody panel and proposes mitigation strategies.

The long non-coding RNA lnc-HLX-2-7 is oncogenic in group 3 medulloblastomas

This study identifies lnc-HLX-2-7 as an oncogenic lncRNA in group 3 medulloblastomas, showing it promotes tumor growth and is regulated by MYC and JQ1.

Disulfiram inhibits M. tuberculosis growth by altering methionine pool, redox status and host-immune response

This study identifies disulfiram as a novel inhibitor of Mtb's methionine biosynthesis, showing anti-tubercular effects through redox disruption and immune modulation.

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis

This study shows that removing the furin cleavage site from SARS-CoV-2 increases replication in Vero cells but reduces replication in respiratory cells and pathogenesis in hamsters, while also decreasing neutralization susceptibility.

Metformin enhances anti-mycobacterial responses by educating immunometabolic circuits of CD8+ T cells

This study shows metformin improves anti-mycobacterial responses by enhancing metabolic and functional properties of CD8+ T cells in mice and humans.

Alpha-1-antitrypsin and its variant-dependent role in COVID-19 pathogenesis

This study investigates the role of alpha-1-antitrypsin in inhibiting SARS-CoV-2 entry and shows variant-dependent effects on its ability to block different viral strains.

Modulating the transcriptional landscape of SARS-CoV-2 as an effective method for developing antiviral compounds

This study identifies antiviral compounds that reduce SARS-CoV-2 viral load by counteracting the virus-induced transcriptional landscape, without affecting viral entry or host antiviral response.

Visual Biochemistry: modular microfluidics enables kinetic insight from time-resolved cryo-EM

This paper introduces a time-resolved cryo-EM method using modular microfluidics to visualize biochemical reactions at near-atomic resolution and millisecond timescales, demonstrating its application to RecA filament formation.

Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early prognostic marker for severe COVID-19

The paper identifies an immature neutrophil-to-VD2 T-cell ratio as a prognostic marker for severe COVID-19 using flow cytometry data.

Stop the crop: insights into the insecticidal mode of action of cinnamodial against mosquitoes

This study identifies the insecticidal mechanism of cinnamodial against mosquitoes by showing it inhibits crop contractility through Ca2+ elevation and tetanic paralysis.

The Viral Polymerase Complex Mediates the Interaction of vRNPs with Recycling Endosomes During SeV Assembly

The paper identifies viral polymerase complex components L and C as mediators of vRNP interaction with Rab11a-marked recycling endosomes during SeV assembly.

Early-life hypoxia alters adult physiology and reduces stress resistance and lifespan in Drosophila

This study shows that early-life hypoxia in Drosophila reduces adult stress resistance and lifespan, with stronger effects in males.

Functional ultrasound speckle decorrelation-based velocimetry of the brain

This paper develops a high-speed, contrast-free ultrasound velocimetry technique for quantifying blood flow velocity in rodent brains and validates it through simulations, phantoms, and in vivo experiments.

Genome-wide transposon mutagenesis of paramyxoviruses reveals constraints on genomic plasticity

This study uses transposon mutagenesis to analyze genomic plasticity in paramyxoviruses, finding structural constraints in envelope glycoproteins and variability in genomic regions.

An inability to maintain the ribonucleoprotein genomic structure is responsible for host detection of negative-sense RNA viruses

The paper shows that limiting nucleoprotein (NP) in negative-sense RNA viruses leads to defective genomes and triggers host interferon responses, making NP a key antiviral target.

Although host-related factors are important for the formation of gut microbiota, environmental factors cannot be ignored

This study compares host-related factors and environmental factors in shaping gut microbiota using fecal samples from naval trainees and healthy individuals, finding host factors more influential.