Osteoarthritis Treatment and Mechanisms

Sex differences in senescence burden within human osteoarthritic synovial fibroblasts

This study finds that female OA synovial fibroblasts show higher senescence markers and reduced oxidative stress response compared to males.

Directing the Chondro-Fibro Axis via Early Microenvironmental Interactions to Enable Precise and Volumetric Cartilage Repair

This study investigates how modulating the Rho-ROCK pathway in microfracture clots can reprogram cells to promote chondrogenic rather than fibrotic repair in cartilage defects.

Modulating Inflammation in Post-Traumatic Osteoarthritis using iPSC-derived Anti-inflammatory Macrophages

This study develops iPSC-derived anti-inflammatory macrophages to treat post-traumatic osteoarthritis, showing they reduce inflammation and improve joint outcomes in preclinical models.

PPAR-γ/PCK1 metabolic pathway modulate synovitis and fibrosis in KOA rats

This study identifies the PPAR-γ/PCK1 metabolic pathway as a regulator of synovitis and fibrosis in KOA rats, showing that PPAR-γ overexpression alleviates inflammation and fibrosis while PCK1 overexpression exacerbates them.

Aggrecan hypomorphism accelerates the progression of post-traumatic osteoarthritis in mice

This study shows that aggrecan hypomorphism in mice accelerates post-traumatic osteoarthritis progression, highlighting aggrecan's role in joint homeostasis.

Spatiotemporal transcriptomic landscape of synovial joint repair - an in vivo murine multimodal model of osteochondral injury

This study uses spatial transcriptomics and imaging to analyze early synovial joint repair in mice, showing distinct cellular microenvironments and their role in tissue regeneration.

Expanded stoichiometric model of chondrocyte metabolism: response to cyclical shear and compressive loading

This study develops a stoichiometric model of chondrocyte metabolism to examine how cyclical shear and compressive loading affect matrix protein synthesis, revealing sex-dependent differences and nitrogen limitations.

Integrin α10β1- selected mesenchymal stem cells are protective in a murine model of post-traumatic osteoarthritis

This study shows that selecting mesenchymal stem cells (MSCs) based on high integrin α10β1 expression improves cartilage protection in a mouse model of post-traumatic osteoarthritis compared to unselected MSCs.

Bioorthogonal Tethering of FGF18 to Annealed Microgel Scaffolds Enhances Cartilage Repair

This paper develops FGF18-tethered microgel scaffolds to enhance cartilage repair by optimizing surface charge and growth factor presentation.

Human growth plates house resting zone sub-populations with features of quiescent stem cells

This study characterizes gene expression in human growth plates, identifying novel markers and sub-populations of resting zone chondrocytes with features of quiescent stem cells.

Interplay between canonical Wnt signaling and α5β1 integrins modulates mechanoresponse in human articular cartilage

This study investigates how Wnt signaling and α5β1 integrins interact to modulate mechanical responses in human cartilage, showing integrins mediate Wnt-driven changes in load responsiveness.

Decorin-mediated Extracellular Matrix Stabilization Maintains Cartilage Integrity During Aging

This study identifies decorin-mediated extracellular matrix stabilization as a key factor in maintaining cartilage integrity during aging, showing its role in preventing age-associated osteoarthritis.

Aging modifies microstructure and material properties of mineralized cartilage and subchondral bone in the murine knee

This study examines age-related changes in mineralized cartilage and subchondral bone in rat tibiae, revealing structural and material alterations linked to joint degeneration.

Acute Effects of Intra-Articular Liposomal IDO-1 following Anterior Cruciate Ligament Injury

This study investigates the acute effects of intra-articular IDO-1 liposomes after ACL injury, showing reduced tryptophan, inflammation markers, and altered T cell ratios, with increased cartilage thickness in rats.

Cross-Species Efficacy of Combinatorial Gene Therapy for Osteoarthritis and Correction of Neuro-Inflammatory Pain Mechanisms

A combinatorial gene therapy targeting inflammation and chondrocyte health slows OA progression and reduces pain in murine and equine models.

Sex-Specific Modulation of Gene Expression by 17beta-Estradiol in Human Meniscal Cells: Pathways to Targeted Osteoarthritis Therapies

This study reanalyzes RNA-seq data to show sex-specific effects of 17beta-estradiol on gene expression in human meniscal fibrochondrocytes, identifying distinct transcriptional programs in males and females.

Sequential intra-articular HCAd-NFκB-IL-1Ra delivery improves therapeutic efficacy in post-traumatic osteoarthritis

This study shows that switching adenovirus serotypes for repeated gene therapy in osteoarthritis improves cartilage preservation but not functional outcomes.

Sensory Neuropeptides Dictate Sex-Specific Synovial Immunity and Cartilage Degeneration in Aging Mice

This study shows that neuropeptides SP and CGRP influence sex-specific synovial immunity and cartilage degradation in aging mice, with their absence providing structural protection.

Spatial transcriptomics defines the mechanisms of hiPSC derived stem cell mediated repair in human articular cartilage

The paper evaluates the therapeutic effects of hiMSCs in osteoarthritis models, showing reduced damage and activation of cholesterol pathways, with spatial transcriptomics revealing localized molecular changes.

Dynasore, the dynamin inhibitor, modulates longitudinal bone growth in a hormetic manner.

This study shows that dynasore, a dynamin inhibitor, has hormetic effects on bone growth, stimulating elongation at low doses and inhibiting growth at high doses.

Allosteric modulation of β1 integrin through the hybrid domain reverses articular cartilage injury and functional impairment in a murine model of inflammatory arthritis

This study shows that allosteric modulation of β1 integrin through its hybrid domain protects cartilage and reduces inflammation in a mouse model of arthritis.

Microfluidic Osteoarthritis-on-a-Chip for Evaluating Joint-Cell Responses to Tanezumab, a Humanized Anti-NGF Monoclonal Antibody

This study evaluates tanezumab's effects on joint cells using a microfluidic co-culture system, revealing differential biomarker responses compared to monoculture.

LAMA5 deficiency disrupts ECM-WNT crosstalk in chondrogenesis and contributes to idiopathic short stature

The paper identifies LAMA5 as a candidate gene for idiopathic short stature, showing its role in ECM-WNT signaling during chondrogenesis and demonstrating partial rescue via WNT activation.

TMEM2-mediated hyaluronan turnover maintains articular cartilage homeostasis during osteoarthritis progression

This study identifies TMEM2 as a regulator of hyaluronan turnover in articular cartilage, showing its role in maintaining ECM integrity during osteoarthritis progression.

Fibronectin Coating of Tissue Culture Polystyrene to Improve Superficial Zone Chondrocyte Expansion

This study shows that fibronectin-coated surfaces improve superficial zone chondrocyte attachment and proliferation but do not fully preserve their phenotype compared to chondrocyte-derived extracellular matrix.

Bioorthogonal Tuning of Hydrogel Stiffness Promotes Zonal Redifferentiation of Passaged Chondrocytes

This study shows that tunable hydrogels can enhance zone-specific chondrocyte phenotypes and promote zonally organized cartilage formation.

TWEAK and Fn14 expression in human osteoarthritis: evidence for TWEAK-induced RANKL release from chondrocytes

This study investigates TWEAK and Fn14 expression in human osteoarthritis cartilage and finds TWEAK induces RANKL release from chondrocytes.

Identification and experimental verification of key genes related to the Ras signaling pathway and the Hippo signaling pathway in osteoarthritis based on transcriptome data

This study identifies KIT and CSF1R as key genes in osteoarthritis using transcriptome data and validates their expression in clinical samples.

Single-cell transcriptomics reveals chondrocyte state transitions and ECM remodeling in osteoarthritic knee cartilage

The paper reanalyzes a public single-cell RNA sequencing dataset to identify chondrocyte state transitions and ECM remodeling in osteoarthritis, finding collagen network hubs as potential targets.

Dissecting the genetic architecture of knee alignment reveals its contribution to osteoarthritis risk

This study identifies 20 genetic loci associated with knee alignment and shows genetic correlation with knee osteoarthritis, suggesting osteoarthritis may causally influence alignment.