Cannabis and Cannabinoid Research

Persistent inflammation promotes endocannabinoid release and presynaptic cannabinoid 1 receptor desensitization

This study shows that persistent inflammation reduces presynaptic CB1R function in rats but maintains eCB activation, with implications for pain therapy development.

Behavioral Phenotyping from deleted CB1 receptors on cholinergic neuron terminals

This study investigates the effects of deleting CB1 receptors on cholinergic neuron terminals in mice, finding WM enhancement and altered timing behavior but no impact on effort-based decision-making.

Induction of Anxiety-Like Phenotypes by Knockout of Cannabinoid Type-1 Receptor in Amygdala of Marmosets

This study shows that knocking out the CB1R in the amygdala of marmosets induces anxiety-like behaviors and increased stress, suggesting a role for CB1R in anxiety regulation.

Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of neuropathic pain

This study shows that CB2 receptors in peripheral sensory neurons are essential for the antinociceptive effects of CB2 agonists and their ability to reverse morphine tolerance in a neuropathic pain model.

Sex-dependent changes in murine striatal dopamine release, sleep, and behavior during spontaneous Δ-9-tetrahydrocannabinol abstinence

This study examines sex-dependent changes in striatal dopamine release, sleep, and behavior during THC abstinence in mice, finding more consistent effects in males.

The acute effects of cannabidiol on emotional processing and anxiety: a neurocognitive imaging study

This study investigates the acute effects of CBD on emotional processing and anxiety using neuroimaging and cognitive measures, finding no significant effects compared to placebo.

Sex-specific differences in rotarod performance and type 1 cannabinoid receptor levels in a rat model of traumatic brain injury treated with {triangleup}9-tetrahydrocannabinol

This study examines sex-specific effects of THC on TBI in rats, finding reduced male rotarod performance and lower CB1R density in female TBI+THC rats.

Cannabinoid 1/2 Receptor Activation Induces Strain-Dependent Behavioral and Neurochemical Changes in GAERS and NEC rats

This study shows that the cannabinoid agonist WIN 55,212-2 has strain-dependent effects on anxiety and motor behavior, along with monoaminergic changes, in GAERS and NEC rats.

The predictive power of mRNA mapping for Cannabinoid 1 receptor protein in the human brain

The paper investigates the association between CNR1 gene expression and CB1 receptor protein expression in the human brain using PET scans and mRNA data, finding moderate to strong correlations.

Cannabinoid receptor 1 is required for neurodevelopment of striosome-dendron bouquets

This study shows that CB1R is essential for the postnatal development of striosome-dendron bouquets, which are critical for dopamine system connectivity, and suggests potential developmental risks from maternal use of CB1R agonists or antagonists.

2-Arachodonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice

This study shows that enhancing 2-AG signaling reduces mechanical hypersensitivity during alcohol withdrawal in mice, suggesting it as a potential therapeutic target for AUD and comorbid pain.

The role of the cannabinoid system in fear memory and extinction in male and female mice

This study investigates sex differences in the role of the cannabinoid system in fear memory and extinction using male and female mice, finding sex-specific effects of endocannabinoid modulation on fear retrieval.

Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis

This study identifies a gut-brain vagal mechanism involving endocannabinoids that regulates food reward and energy homeostasis, showing that peripheral CB1 receptor inhibition reduces palatable eating.

Autocrine regulation of adult neurogenesis by the endocannabinoid 2-arachidonoylglycerol (2-AG)

The paper identifies DAGLa in neuronal progenitor cells and astrocytes in the dentate gyrus as the source of 2-AG that regulates adult hippocampal neurogenesis.

Revealing genomic changes responsible for cannabinoid receptor loss in parrots: mechanism and functional effects

The paper investigates CNR2 pseudogenization in parrots, showing increased IL1B expression in the brain during inflammation, suggesting functional consequences of CNR2 loss.

Cannabinoids regulate an insula circuit controlling water intake

This study identifies CB1 receptor-mediated circuit mechanisms in the insula that regulate water intake, showing distinct roles of anterior and posterior insula projections to the basolateral amygdala.

Collagen VI regulates motor circuit plasticity and motor performance by cannabinoid modulation

This study identifies a synaptic mechanism linking collagen VI to motor control through cannabinoid receptor interaction and shows that CB1R agonists can improve motor performance in a dystonia mouse model.

The cannabinoid agonist CB-13 produces peripherally mediated analgesia in mice but elicits tolerance and signs of CNS activity with repeated dosing

This study evaluates CB-13, a peripherally selective CB1 agonist, showing it reduces pain in mice but develops tolerance and CNS effects with repeated dosing.

Cannabinoid during adolescence phenocopies reelin haploinsufficiency in prefrontal cortex synapses

This study shows that adolescent cannabinoid exposure reduces prefrontal reelin expression and impairs synaptic plasticity, mimicking reelin haploinsufficiency.

RTICBM-74 is a Brain-Penetrant CB1 Receptor Allosteric Modulator that Reduces Alcohol Intake in Rats

The paper tests a CB1 receptor NAM, RTICBM-74, showing it reduces alcohol intake in rats without affecting locomotion or sucrose self-administration.

Pharmacokinetics and Central Accumulation of Delta-9-Tetrahydrocannabinol (THC) and its Bioactive Metabolites are Influenced by Route of Administration and Sex

This study compares THC and metabolite pharmacokinetics in rats after inhalation vs. injection, finding route-specific differences in brain and blood levels and hypothermic responses.

Deficiency in endocannabinoid synthase DAGLB contributes to Parkinson's disease and dopaminergic neuron dysfunction

This study shows that deficiency in DAGLB, an endocannabinoid synthase, contributes to Parkinson's disease by impairing dopaminergic neuron function and motor learning, with potential therapeutic implications for 2-AG augmentation.

2-Arachidonoylglycerol mobilization following brief synaptic stimulation in the dorsal lateral striatum requires glutamatergic and cholinergic neurotransmission

This study investigates the mechanisms of 2-AG mobilization in the dorsal lateral striatum following synaptic stimulation, revealing the roles of glutamatergic and cholinergic neurotransmission.

Cannabis Vapour Exposure Alters Neural Circuit Oscillatory Activity In A Neurodevelopmental Model Of Schizophrenia: Exploring The Differential Impact Of Cannabis Constituents

This study examines how cannabis vapour with THC or balanced THC:CBD affects oscillatory activity in a schizophrenia model, finding THC suppresses activity while CBD balances its effects.

A fluorescent sensor for spatiotemporally resolved endocannabinoid dynamics in vitro and in vivo

The paper introduces a genetically encoded fluorescent sensor, GRABeCB2.0, to measure endocannabinoid dynamics with high spatiotemporal resolution in vitro and in vivo, revealing new insights into eCB signaling in neurons and brain regions.

In vivo imaging of cannabinoid type 2 receptors, functional and structural alterations in mouse model of cerebral ischemia by PET and MRI

This study uses PET and MRI to assess CB2R levels and metabolic changes in a mouse model of cerebral ischemia, finding increased CB2R and reduced glucose metabolism in the ischemic striatum.

Postsynaptic synucleins mediate vesicular exocytosis of endocannabinoids

The paper identifies synucleins as essential for vesicular exocytosis of endocannabinoids, linking their role in Parkinson's Disease to synaptic plasticity.

Chronic THC vapor rescues inflammation-related thermal hyperalgesia and causes cell type-specific modifications in vlPAG neurons

This study examines chronic THC vapor inhalation's effects on pain and vlPAG neuronal function in rats, finding sex-specific rescue of thermal hyperalgesia and cell type-specific modifications in neuronal properties.

Epigenetic mediation of AKT1 rs1130233 s effect on delta-9-tetrahydrocannabinol-induced medial temporal function during fear processing

The paper examines how genetic and epigenetic factors at AKT1 rs1130233 modulate THC-induced brain activation during fear processing in healthy males.

Genomic evidence that governmentally produced Cannabis sativa poorly represents genetic variation available in state markets

This study shows that NIDA-produced Cannabis sativa lacks genetic diversity compared to state market varieties, limiting the generalizability of research findings.