Regulation of Appetite and Obesity

Protein-coding mutation in Adcy3 increases adiposity and alters emotional behaviors sex-dependently in rats

This study shows that a protein-coding mutation in Adcy3 increases adiposity and alters emotional behaviors in rats, with sex-dependent effects on metabolism and behavior.

Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for Satiety

The paper identifies a neural circuit involving TrhArc neurons that mediate the appetite-suppressing effects of GLP-1RAs by inhibiting AgRP neurons.

AgRP neurons mediate activity-dependent development of oxytocin connectivity and autonomic regulation

This study shows that leptin-mediated AgRP neuronal activity during postnatal life is essential for proper development of PVH oxytocin projections and autonomic regulation.

Melanocortin-4 receptor antagonist TCMCB07 alleviates chemotherapy-induced anorexia and weight loss

This study shows that TCMCB07, a melanocortin-4 receptor antagonist, reduces chemotherapy-induced anorexia and weight loss in rat models.

Rapid fluctuations in histamine associated with intake of nutritive and non-nutritive solutions

This study measures histamine dynamics during feeding in mice and finds rapid fluctuations influenced by solution type and time of day, with regional differences in recovery patterns.

Competition between stochastic neuropeptide signals calibrates the rate of satiation

The paper shows how stochastic neuropeptide signals (NPY and MSH) compete to regulate cAMP levels in neurons, influencing satiation through state-dependent integration.

A Normative Framework Dissociates Need and Motivation in Hypothalamic Neurons

The paper develops a normative framework to distinguish need and motivation in hypothalamic neurons using computational models and experimental paradigms, showing AgRP and LHLepR neurons encode need and motivation respectively.

Leptin Activated Hypothalamic BNC2 Neurons Acutely Suppress Food Intake

The paper identifies BNC2 neurons in the hypothalamus that acutely suppress food intake by inhibiting AGRP neurons and are regulated by leptin, sensory cues, and nutritional status.

Early perturbations to fluid homeostasis alter development of hypothalamic feeding circuits with context-specific changes in ingestive behavior

The paper shows early fluid homeostasis disruptions affect hypothalamic feeding circuits and alter ingestive behavior in specific contexts.

Melanin-concentrating hormone promotes feeding through the lateral septum

This study shows that melanin-concentrating hormone (MCH) promotes feeding via the lateral septum in both male and female mice, with context-dependent effects.

Cav3.1 is a leucine sensor in POMC neurons mediating appetite suppression and weight loss

Sex-dependent effects of a high-fat diet on the hypothalamic response in mouse

This study examines sex differences in mouse hypothalamic responses to a high-fat diet, finding sex-specific effects on body weight, neuropeptide expression, and glial activation.

Pharmacological blockade of glutamatergic input to the lateral habenula modulates consumption of palatable diet components in male Wistar rats

This study investigates the effect of blocking glutamatergic input to the lateral habenula on palatable diet consumption in rats, finding no major acute effects but some long-term changes.

Leptin activation of dorsal raphe neurons inhibits feeding behavior

This study identifies a novel leptin-mediated pathway involving DRN-ARC neurons and serotonin to reduce food intake in rats.

2-monopalmitin, but not 1-monopalmitin, enhances hypothalamic leptin responsiveness, energy balance, and glucose homeostasis under overnutrition

This study shows that 2-monopalmitin, but not 1-monopalmitin or palmitic acid, improves hypothalamic leptin responsiveness and metabolic outcomes under overnutrition.

A Hypothalamic Circuit that Modulates Feeding and Parenting Behaviors

This study identifies a hypothalamic circuit involving ARCAgRP and MPOABRS3 neurons that modulates the prioritization of feeding and parenting behaviors during lactation.

The Novel Chimeric Multi-Agonist Peptide (GEP44) Reduces Energy Intake and Body Weight in Male and Female Diet-Induced Obese Mice in a Glucagon-Like Peptide-1 Receptor-Dependent Manner

This study shows that the chimeric peptide GEP44 reduces body weight and energy intake in diet-induced obese mice, primarily through GLP-1R signaling, with some GLP-1R-independent effects in males.

A method for evaluating hunger and thirst in monkeys by measuring blood ghrelin and osmolality levels

The paper measures blood ghrelin and osmolality in monkeys to assess hunger and thirst states under controlled food and water access conditions.

AgRP1 modulates breeding season-dependent feeding behavior in female medaka

This study identifies agrp1 as a key regulator of breeding season-dependent feeding behavior in female medaka by linking ovarian estrogenic signals to increased food intake.

Mice lacking dopamine production in neurotensin receptor 1 neurons voluntarily undergo time-restricted feeding of high fat diet and resist obesity

This study shows that mice lacking dopamine production in neurotensin receptor 1 neurons resist obesity on a high fat diet by not increasing daytime eating.

Remodeling of purinergic signaling in the paraventricular hypothalamus promotes hyperphagic obesity and insulin resistance

This study shows that high-fat diet induces purinergic signaling in the hypothalamus, leading to obesity and insulin resistance, and that targeting P2Y12 can reverse these effects.

Food and water uptake are regulated by distinct central amygdala circuits revealed using intersectional genetics

The paper identifies distinct central amygdala circuits regulating food and water uptake using intersectional genetics and in vivo calcium imaging.

Reward responses to vicarious feeding depend on BMI

This study uses fMRI to show that vicarious feeding activates motor and affective brain regions and that these responses decrease with higher BMI.

Functional coupling between MC4R and Kir7.1 contributes to clozapine-induced hyperphagia

This study identifies a molecular pathway involving MC4R and Kir7.1 that mediates clozapine-induced hyperphagia and weight gain in mice.

Integrated genomic analysis of AgRP neurons reveals that IRF3 regulates leptin's hunger-suppressing effects

The paper identifies IRF3 as a key transcriptional regulator of leptin's hunger-suppressing effects in AgRP neurons through integrated genomic analysis.

Regulation of the mouse ventral tegmental area by melanin-concentrating hormone

This study investigates how MCH regulates dopamine release in the VTA by directly inhibiting dopaminergic cells and modulating local microcircuit activity.

Hypothalamic Sex-Specific Metabolic Shift by Canagliflozin during Aging

This study shows Canagliflozin improves metabolic control in aged male mice but not females, with sex-specific effects on hypothalamic gene expression and metabolic pathways.

Dorsolateral septum GLP-1R neurons regulate feeding via lateral hypothalamic projections

This study identifies dLSGLP-1R neurons and their GABAergic projections to the LHA as regulators of feeding behavior in mice, showing that inhibition of these pathways increases food intake.

Reducing neuronal nitric oxide synthase (nNOS) expression in the ventromedial hypothalamus (VMH) increases body weight and blood glucose levels while decreasing physical activity in female mice.

The paper reduces nNOS in VMH of female mice and observes increased body weight, blood glucose, and reduced activity, contradicting the hypothesis about orexin neuron inhibition.

Reversal of Obesity by Enhancing Slow-wave Sleep via a Prokineticin Receptor Neural Circuit

This study identifies a neural circuit linking appetite and sleep regulation, showing that targeting it with pterostilbene reduces obesity and improves sleep in diet-induced obese mice.