Autophagy in Disease and Therapy

A live-cell autophagy reporter reveals reversible vacuolation in naked mole-rat skin fibroblasts under lysosomal stress

This study uses a live-cell autophagy reporter to show that naked mole-rat skin fibroblasts form reversible vacuoles under lysosomal stress, indicating dynamic lysosomal remodelling.

Comparative analysis of neuronal proteolytic pathways reveals neuron-specific and sub-compartmental-specific capacities with aging

This study compares proteolytic pathway activity in neuronal compartments across aging in mice and C. elegans, revealing age-related differences in UPS and macroautophagy.

Characterization of Vlf1 as a regulator of lipophagy.

This study identifies Vlf1 as a vacuolar lipophagy regulator in S. cerevisiae, showing its localization to the vacuole and interaction with Atg15, with effects on autophagy levels.

LC3C-ATG4D regulatory axis supports coronavirus replication organelle formation independently of canonical autophagy

This study identifies a non-canonical role for the LC3C-ATG4D axis in supporting coronavirus replication organelle formation, independent of canonical autophagy.

Activation of pro-survival autophagy by a small molecule promoting p62 oligomerisation

The paper identifies SQ-1 as a small molecule that activates autophagy by promoting p62 oligomerisation, improving mitochondrial clearance and cell viability in NPC1 disease models.

Structural basis for the selective inhibition of the PI3KC3-C2 complex by Rubicon in endolysosome maturation and mitophagy

This paper determines the cryo-EM structure of the PI3KC3-C2 complex with Rubicon's PIKBD domain, revealing how Rubicon selectively inhibits PI3KC3-C2 to regulate endolysosome maturation and mitophagy.

Autophagy promotes tumor growth through facilitating JAK/STAT signaling in a lysosomal degradation independent manner

This study shows that autophagy promotes tumor growth by enhancing JAK/STAT signaling independently of lysosomal degradation in Drosophila models.

Intertwined Autophagy and Integrin Dynamics Shape Axon Growth and Regeneration

This study investigates the relationship between autophagy and integrin dynamics in axon growth and regeneration, finding a bidirectional feedback system that regulates these processes.

Astrocytes mobilize a broader repertoire of lysosomal repair mechanisms than neurons

The paper compares lysosomal repair mechanisms in neurons and astrocytes, finding astrocytes use more robust ESCRT and RAB7-GAP pathways for lysosomal repair.

Autophagy-Mediated Antitumor Effects of BCG and Imiquimod in Oral Squamous Cell Carcinoma

This study shows that TLR agonists BCG and imiquimod induce autophagy, reducing tumor volume and improving survival in OSCC, with effects comparable to cisplatin but with less toxicity.

Nutrient stress activates Rab5b-mediated autophagy to remodel the synaptic proteome

The paper shows nutrient stress activates Rab5b-mediated autophagy at synapses, leading to proteome remodeling, distinct from mTORC1 inhibition effects.

A GABARAP-PtdIns3K-C1 positive feedback loop at the heart of the phagophore nucleation

The paper identifies a positive feedback loop between GABARAP and PtdIns3K-C1 that drives PtdIns3P production, essential for autophagosome biogenesis.

Germline mitophagy selectively eliminates deleterious mitochondrial DNA across generations

This study shows that germline mitophagy selectively removes mutant mitochondrial DNA in C. elegans, reducing their transmission to offspring across generations.

Transport of endo-β-mannosidase AtEBM from cytoplasm to the vacuole through autophagy pathway in Arabidopsis

This study identifies a Cvt-like autophagy pathway in Arabidopsis that transports endo-β-mannosidase AtEBM to the vacuole for glycan degradation.

A GSK3-dependent phosphorylation switch licenses BNIP3-mediated mitophagy

This study identifies GSK3-dependent phosphorylation of BNIP3 as a molecular switch that activates mitophagy by promoting WIPI protein recruitment.

KIF1A-mediated trafficking is required for neuronal autophagy in human neurons

This study shows that KIF1A mutations impair autophagy in human neurons by disrupting ATG9 trafficking and lysosomal function, contributing to KAND pathogenesis.

Organ identity shapes autophagy dynamics and selectivity in plants

This study examines autophagy dynamics and selectivity in Arabidopsis roots and shoots under stress, finding stronger autophagy in roots and distinct cargo selection patterns.

Structural and mechanistic basis for membrane recognition and activation of the vacuolar lipase Atg15

This study identifies structural and mechanistic principles of Atg15 activation and membrane recognition using MD simulations and experimental validation.

Treatment of Saccharomyces cerevisiae with cigarette smoke extract causes vacuolar fragmentation to combat cigarette smoke-induced cellular toxicity

This study shows that cigarette smoke extract induces vacuolar fragmentation in yeast to combat oxidative stress and misfolded proteins, but excessive fragmentation leads to cellular toxicity.

Epithelial-Mesenchymal Transition Induces FAM134A-mediated ER-phagy to Regulate Procollagen Secretion

The paper shows that EMT activates ER-phagy to regulate procollagen secretion, with FAM134A uniquely mediating this process through a non-canonical mechanism.

Endogenous autophagosome reporters reveal redundant and non-redundant roles of LGG-1 and LGG-2 in C. elegans neuronal autophagy

Vimentin intermediate filaments support autophagosome biogenesis at ER-endosomes contact sites in response to starvation

This study shows vimentin intermediate filaments reorganize to mobilize ER-endosome contact sites, promoting autophagosome biogenesis during starvation.

SH3KBP1/CIN85, a new actor of ER-phagy in muscle

This study identifies SH3KBP1 as a novel ER-phagy receptor in striated skeletal muscle, showing it binds LC3B and CKAP4 to mediate ER degradation via autophagy.

Reciprocal regulation of autophagy and exosome pathway is mediated by GABARAPL2 and Alix to facilitate cellular homeostasis

This study shows that combined inhibition of autophagy and exosome pathways reduces cancer cell proliferation, with GABARAPL2 regulating Alix expression to control exosome secretion.

Actin nucleation promoting factors drive Arp2/3 dependent endosomal microautophagy

This study identifies actin nucleation promoting factors as regulators of endosomal microautophagy, showing that Wash is essential for physiological e-MI induction.

SOLAR Mediates Lysosomal Membrane Repair and Redox Defense

This study identifies SOLAR as a lysosomal quality control pathway that links CASM to p62-driven membrane repair and redox signaling, with implications for aging and degenerative disease.

FYCO1 improves postischemic cardiac remodeling via enhanced autophagic flux and attenuation of proinflammatory signaling

This study identifies FYCO1 as a regulator of autophagy that improves cardiac remodeling after myocardial infarction by enhancing autophagic flux and reducing inflammation.

CASM regulates p62/KEAP1/NRF2 antioxidant responses to lysosome damage

This study identifies CASM as a regulator of antioxidant responses to lysosome damage by activating the p62/KEAP1/NRF2 pathway.

Rapid optogenetic blockade of autophagy reveals that nuclear pore complex proteins are robust autophagy substrates

The paper develops an optogenetic tool to rapidly inhibit autophagy and identifies nuclear pore complex proteins as autophagy substrates.

Intercellular mitochondrial transfer and transmitophagy in response to protein import dysfunction

The paper investigates intercellular mitochondrial transfer and transmitophagy in response to protein import dysfunction, showing distinct mitochondrial fates and degradation mechanisms.