Genetics, Aging, and Longevity in Model Organisms

Parallel Selection for Longevity in Mammals and Birds

This study identifies shared genetic pathways and genes under positive selection in long-lived mammals and birds, suggesting convergent evolution of longevity mechanisms.

Age-dependent topoisomerase I depletion alters recruitment of rDNA silencing complexes

The paper identifies topoisomerase I (Top1) depletion in aging yeast cells and shows its impact on rDNA silencing and replicative lifespan.

Protein aggregation drives cell aging in a size-specific manner in Escherichia coli

This study shows that protein aggregation in E. coli drives aging by reducing intracellular space, leading to larger cell sizes and asymmetric divisions.

Discrimination of Normal from Slow-Aging Mice by Plasma Metabolomic and Proteomic Features

The paper uses machine learning to identify plasma metabolomic and proteomic features that distinguish slow-aging mice from controls, finding triglycerides with varying fatty acid chain lengths as key predictors.

Sex- and age-differences in cellular hallmarks of aging in a species with female-biased longevity and environmental sex determination

The paper examines sex- and age-related differences in cellular aging markers in painted turtles, finding sex is a stronger predictor of aging physiology than age or size.

Cyrene: A Novel Geroprotective Compound that Extends Lifespan and Healthspan in C. elegans and Drosophila

This paper identifies Cyrene as a geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila, improving stress resistance and neuroprotection.

Warmer temperature accelerates senescence by modifying the aging-dependent changes in the mosquito transcriptome, altering immunity, metabolism, and DNA repair

This study shows that warmer temperatures accelerate senescence in mosquitoes by altering transcriptome changes related to immunity, metabolism, and DNA repair.

Insulin-like peptides play distinct roles in nutrient-dependent plasticity in Drosophila

The paper investigates how different dietary macronutrient conditions affect insulin-like peptide expression and developmental outcomes in Drosophila.

DNA Replication Asymmetry as a Modifier of Proteostasis Collapse Dynamics

The paper develops a stochastic model to evaluate how DNA replication asymmetry affects proteostasis collapse dynamics under age-related clearance decline, finding that asymmetry modestly increases load and accelerates collapse under stress.

Early life sleep is associated with longevity in Drosophila

This study investigates how sleep at different life stages affects longevity in Drosophila, finding that early life sleep is positively associated with longer lifespan.

Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families

The paper identifies rare longevity-associated variants, including a cGAS mutation, in long-lived families and shows they reduce inflammation and delay cellular senescence.

SWR1C loss promotes longevity through tRNA-mediated proteostasis

This study identifies tRNA-mediated proteostasis as a mechanism by which SWR1C loss extends longevity in yeast.

A linear regression model predicts human brain ageing and reveals differential neuronal biological ageing relevant for Parkinson's disease susceptibility

The paper develops a linear regression model to predict biological brain ageing and identifies age-related gene expression patterns linked to Parkinson's disease susceptibility.

RNA degradation modulates unique aging-related gene expression in naked mole-rats

This study examines RNA synthesis and degradation rates in naked mole-rat and mouse fibroblasts, finding higher degradation rates in aging-related pathways in NMRs.

Lysosomal control of proteostasis and reproductive capacity by conserved LMD-3 protein in C. elegans

This study identifies LMD-3 as a regulator of proteostasis and reproductive capacity in C. elegans, showing its role in lysosomal function and the reversibility of fecundity decline with vitamin B12.

A metabolic atlas of mouse aging

This study maps metabolic changes in 12 organs of male and female mice across 5 ages, identifying sex-specific patterns and a metabolic aging clock.

Distinct mechanisms of non-autonomous UPRER mediated by GABAergic, glutamatergic, and octopaminergic neurons.

The paper identifies distinct roles of GABAergic, glutamatergic, and octopaminergic neurons in mediating non-autonomous UPRER through transcriptomic and functional analyses in C. elegans.

Broad Effects of Activation of Alcohol Dehydrogenase 1 on Healthspan Extension

This study shows that activating ADH-1 extends healthspan in multiple species by improving proteostasis and reducing age-related diseases.

Kruppel-like factor 1 acts upstream of the SKN-1/Nrf transcription factors to modulate oxidative stress, lipid homeostasis and longevity

This study identifies KLF-1 as an upstream regulator of SKN-1/Nrf transcription factors in C. elegans, linking lipid homeostasis, oxidative stress, and longevity.

Life-long behavioral screen reveals an architecture of vertebrate aging

The paper develops a platform for continuous behavioral tracking of vertebrates across their lifespan and identifies distinct aging trajectories linked to transcriptomic changes and predictive models of lifespan.

INS-17, an insulin-receptor ligand, confers specificity in adult IIS-regulated phenotypes in C. elegans

The paper identifies INS-17 as a specific insulin-receptor ligand in C. elegans that regulates learning and memory independently of lifespan.

A gut-microbiota-muscle axis that protects against age-related motor decline by regulating mitochondrial fission in C. elegans

This study identifies a gut microbiota-muscle axis in C. elegans that protects against age-related motor decline by regulating mitochondrial fission through DRP-1.

Deciphering the Timing and Impact of Life-extending Interventions: Temporal Efficacy Profiler Distinguishes Early, Midlife, and Senescence Phase Efficacies

The paper introduces a tool to estimate age-specific treatment effects on mortality hazards, applied to mouse data showing varying efficacy of life-extending interventions across lifespan stages.

Epigenomic and transcriptomic germ-free ageing atlas reveals sterile inflammation as an intrinsic ageing feature

This study presents a single-cell epigenomic and transcriptomic atlas of aged mice under germ-free conditions, revealing sterile inflammation as an intrinsic ageing feature.

Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways

The paper identifies E. coli mutants that extend C. elegans lifespan via oxidative stress and iron homeostasis pathways.

Impacts of stress and aging on spore health in Schizosaccharomyces pombe

This study examines how stress and aging affect spore health in Schizosaccharomyces pombe, identifying declines in germination, asymmetry, and stress tolerance.

Disruption of the insulin signaling pathway in C. elegans dramatically increases male longevity and enhances reproductive health late in life

This study shows that disrupting the insulin signaling pathway in male C. elegans significantly increases lifespan and improves reproductive health late in life.

Transcriptomic analysis of mitohormesis associated with lifespan extension in Caenorhabditis elegans

This study uses RNA-sequencing to analyze transcriptomic changes in C. elegans under different mitochondrial stressors that activate UPRmt, aiming to determine if specific transcriptomic changes correlate with longevity.

Aging represses lung tumorigenesis and alters tumor suppression

This study shows aging suppresses lung tumor initiation and growth in mice, with age-dependent effects on tumor suppressor genes like PTEN and persistent age-related transcriptomic changes in tumors.

Estrogen-Mediated Suppression of IL-11 as a Hormonal Mechanism Underlying Female Longevity Advantage

This paper identifies estrogen-mediated suppression of IL-11 as a hormonal mechanism contributing to female longevity advantage by reducing inflammaging and multi-organ fibrosis.