Wnt/β-catenin signaling in development and cancer

A Wnt-specific astacin proteinase controls head formation in Hydra

This study identifies HAS-7, an astacin proteinase, as a Wnt processing factor that regulates head formation in Hydra by controlling Wnt ligand activity and axis patterning.

Wnt/PCP-primed intestinal stem cells directly differentiate into enteroendocrine or Paneth cells

The paper identifies Wnt/PCP-activated Lgr5+ intestinal stem cells that directly differentiate into enteroendocrine or Paneth cells, challenging previous models of multipotency.

Characterisation of protein isoforms encoded by the Drosophila Glycogen Synthase Kinase 3 gene shaggy

The paper characterizes protein isoforms of the Drosophila sgg gene, revealing distinct localization, interactions, and functions for different proteoforms during development.

Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors

This study shows Nanog represses maternal β-catenin activity by interfering with TCF factors, preventing hyper-dorsalization in early embryos.

A novel Axin2 knock-in mouse model for visualization and lineage tracing of WNT/CTNNB1 responsive cells

This paper describes a novel Axin2 knock-in mouse model that visualizes and traces WNT/CTNNB1 responsive cells through fluorescent reporting and lineage tracing.

Single molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation

This study uses single-molecule imaging to analyze Dvl2 dynamics and oligomerization during Wnt pathway activation, showing increased oligomerization and dwell time upon Wnt3a stimulation.

Allele-specific endogenous tagging and quantitative analysis of beta-catenin in colorectal cancer cells

This study uses genome engineering to fluorescently tag wild-type and mutant beta-catenin alleles in colorectal cancer cells, revealing distinct biophysical properties and showing how Wnt signaling modulates wild-type behavior to resemble the mutant form.

ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling

This study shows ADNP is essential for neural differentiation by maintaining Wnt/β-catenin signaling, and its disruption causes neural developmental defects in mice and zebrafish.

FZD10 regulates cell proliferation and mediates Wnt1 induced neurogenesis in the developing spinal cord

This study identifies FZD10 as a receptor for Wnt1 in spinal cord development, showing it regulates neurogenesis and proliferation, but requires Lrp6 for full activity.

Wnt ligands are not required for planar cell polarity in the Drosophila wing or notum

This study investigates whether Wnt ligands are required for planar cell polarity in Drosophila wing and notum, finding no evidence supporting their role.

Lgr5 Controls Extracellular Matrix Production By Stem Cells In The Developing Intestine

This study shows Lgr5 regulates extracellular matrix production in fetal intestinal stem cells, affecting their maturation and niche environment.

Redundant and additive functions of the four Lef/Tcf transcription factors in lung epithelial progenitors

The paper investigates the functional redundancy and additivity of four Lef/Tcf transcription factors in lung epithelial progenitors using genetic knockout models in mice.

β-catenin Signaling Regulates Cell Fate Decisions at the Transition Zone of the Chondro-Osseous Junction During Fracture Healing

This study shows that β-catenin signaling regulates chondrocyte-to-osteoblast transformation during fracture healing and identifies its role in stem cell generation for repair.

Variability in β-catenin pulse dynamics in a stochastic cell fate decision in C. elegans

The paper examines variability in β-catenin pulse dynamics during a stochastic cell fate decision in C. elegans and links BAR-1 pulse timing to cell fate outcome.

Disruption of EGF feedback by intestinal tumors and neighboring cells in Drosophila

This paper shows that APC-/- tumors in Drosophila disrupt EGF feedback by inducing Rho in both neighboring and tumor cells, leading to chronic EGF signaling and cancerous overgrowth.

Modulation of the canonical Wnt activity by androgen signaling in prostate epithelial basal stem cells

This study shows androgen signaling modulates canonical Wnt activity in prostate basal stem cells, maintaining their multipotency by suppressing Wnt-driven differentiation.

Surrogate R-spondins for tissue-specific potentiation of Wnt signaling

The paper describes engineered surrogate R-spondins that enhance Wnt signaling in specific cell types by bypassing natural receptor interactions.

Cross-talk between Hippo and Wnt signalling pathways in intestinal crypts: insights from an agent-based model

The paper develops an agent-based model to study the interaction between Hippo and Wnt signaling pathways in intestinal crypts, showing Hippo reduces β-catenin and slows crypt turnover, and division-based Wnt spreading can form gradients.

Developmentally regulated tcf7l2 splice variants mediate transcriptional repressor functions during eye formation

The paper identifies tcf7l2 splice variants that mediate repressor functions in eye formation by interacting with Tle co-repressors and phosphorylated residues.

C. elegans Runx/CBFβ suppresses POP-1(TCF) to convert asymmetric to proliferative division of stem cell-like seam cells

ΔN-Tp63 mediates Wnt/β-catenin-induced inhibition of differentiation in basal stem cells of mucociliary epithelia

This study identifies ΔN-Tp63 as a key mediator of Wnt/β-catenin signaling in basal stem cells of mucociliary epithelia, showing its role in inhibiting differentiation and promoting hyperplasia.

Umbelliprenin isolated from Ferula sinkiangensis inhibits tumor growth and migration through the disturbance of Wnt signaling pathway in gastric cancer

This study shows that umbelliprenin inhibits gastric cancer cell migration and growth by disrupting the Wnt signaling pathway.

PI4K2β constrains non-canonical Wnt-PCP signalling and is localised by PAR-1 (MARK2/3) phosphorylation

The paper identifies PI4K2β as a PAR-1 substrate that inhibits both canonical and non-canonical Wnt pathways, contrasting with PI4K2 which only affects canonical signalling.

Synergy with TGFβ ligands switches WNT pathway dynamics from transient to sustained during human pluripotent cell differentiation

The paper investigates how TGFβ ligands alter WNT/{beta}-catenin signaling dynamics during human pluripotent cell differentiation, showing a shift from transient to sustained responses.

Axin proteolysis by Iduna is required for the regulation of stem cell proliferation and intestinal homeostasis in Drosophila

This study shows that Iduna regulates Axin proteolysis, which controls stem cell proliferation and intestinal homeostasis in Drosophila.

Wnt/Fgf crosstalk is required for the specification of tracheal basal progenitor cells

This study identifies the role of Wnt/Fgf crosstalk in tracheal basal progenitor cell specification through genetic ablation experiments in mouse models.

Evidence of functional long-range Wnt/Wg in the developing Drosophila wing epithelium

The paper shows that Wg spreads up to eleven cell distances in Drosophila wing epithelium and that cells outside this range rely on Frizzled2 for target gene expression.

Intracellular pH controls Wnt signaling downstream of glycolysis in the vertebrate embryo

The paper shows that aerobic glycolysis increases intracellular pH in tail bud cells, promoting β-catenin acetylation and Wnt signaling, which drives mesodermal fate over neural fate.

The Wnt segment polarity pathway and TMED2 protein may interact via a lectin- and decoy-type mechanism

The paper models the interaction between p24-GOLD domain and Wnt8, suggesting a lectin-like binding mechanism and potential decoy-like quenching of Wnt signaling.

Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling