Wnt/β-catenin signaling in development and cancer

Pegasus, a small extracellular peptide regulating the short-range diffusion of Wingless

The paper identifies a small peptide, pegasus, that enhances Wg diffusion during Drosophila wing development, contributing to proper wing margin formation.

Glypican4 mediates Wnt transport between germ layers via signaling filopodia

The paper shows that Glypican4 mediates Wnt transport between germ layers via signaling filopodia in zebrafish, rescuing convergence and extension defects.

SOX transcription factors direct TCF-independent WNT/beta-catenin transcription.

The paper shows SOX transcription factors mediate WNT/{beta}-catenin transcription independently of TCFs during hPSC differentiation into DE and NMPs.

Spatial organisation and homeostasis of epithelial lineages at the gastroesophageal junction is regulated by the divergent Wnt mucosal microenvironment

The paper identifies the spatial organisation and regulatory mechanisms of epithelial lineages at the gastroesophageal junction using multi-omics approaches and shows that Wnt microenvironments maintain homeostasis without lineage plasticity.

Wnt target enhancer regulation by a CDX/TCF transcription factor collective and a novel DNA motif

The paper identifies a Wnt-responsive enhancer element regulated by a TCF/CDX complex and a novel CAG DNA motif, revealing complex cis- and trans- interactions in enhancer activity.

Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification

This study shows Rspo2 inhibits TCF3 phosphorylation to block Wnt signaling during Xenopus anteroposterior axis development.

Wnt-dependent activation of ERK mediates repression of chondrocyte fate during calvarial development.

The paper shows that Wnt and ERK signaling pathways work together to repress Sox9 and control cell fate in cranial mesenchyme during calvarial development.

Proteomic analysis identifies the E3 ubiquitin ligase Pdzrn3 as a regulatory target of Wnt5a-Ror signaling

The paper identifies Pdzrn3 as a target of Wnt5a-Ror signaling through proteomic analysis and shows its degradation is essential for cell migration.

A landscape model for cell fate decisions during mesoendoderm differentiation in C. elegans based on Wnt dynamics

The paper constructs a Waddington landscape model to predict cell fate decisions during C. elegans mesoendoderm differentiation based on Wnt dynamics and mutant penetrance data.

A single heterozygous mutation in COG4 disrupts zebrafish early development via Wnt signaling

The paper investigates how a COG4 mutation causes SWS by disrupting non-canonical Wnt signaling in zebrafish and fibroblasts, leading to developmental defects.

Crosstalk between Fat Mass and Obesity-related (FTO) and multiple WNT signaling pathways

This study identifies FTO's role in regulating multiple WNT signaling pathways, revealing its impact on canonical and noncanonical WNT signaling through RNA demethylation and DKK1 upregulation.

The self-regulated response of the Wnt pathway to an oncogenic mutation in β-catenin

The paper investigates how an oncogenic mutation in β-catenin affects the Wnt pathway by altering phosphorylation and degradation mechanisms.

Quantitative analyses reveal extracellular dynamics of Wnt ligands in Xenopus embryos

The paper quantifies Wnt8 ligand dynamics in Xenopus embryos, showing most Wnt8 is bound to cell surfaces with dynamic exchange, leading to a graded distribution.

Arf6 is necessary for high level Wingless signalling during Drosophila wing development

This study shows Arf6 is required downstream of Armadillo/β-catenin stabilization for high-level Wingless signaling in Drosophila wing development.

Vangl2 regulates the dynamics of Wnt cytonemes in vertebrates

This study shows that Vangl2 regulates cytoneme dynamics, affecting Wnt/{beta}-catenin signaling and tissue patterning in vertebrates.

Extracellular spreading of Wingless is required for Drosophila oogenesis

The paper shows that Wg spreads extracellularly in the Drosophila ovary to promote follicle stem cell proliferation, as demonstrated by the fertility defects in hemizygous NRT-wg/null flies.

A dual role for Axin in establishing the anterior-posterior axis in the early sea urchin embryo

This study investigates Axin's role in inhibiting Wnt signaling in sea urchin embryos to regulate anterior-posterior axis patterning, showing that Axin's interaction with GSK-3β is critical for this function.

A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

The paper shows that β-catenin modulates TCF/LEF binding at gene targets, switching from inhibitory to activating complexes during nephron progenitor cell differentiation.

ToxCast chemical library screen identifies diethanolamine as an activator of Wnt signaling

The paper screens a chemical library to identify environmental chemicals that modulate Wnt signaling, finding diethanolamine as a stimulator with potential for prenatal exposure.

Sox2 levels configure the WNT response of epiblast progenitors responsible for vertebrate body formation

The paper shows that Sox2 levels determine how WNT signaling affects epiblast progenitors, influencing pluripotency and mesodermal differentiation through changes in chromatin occupancy and regulatory element selection.

Functional analysis of caspase cleavable proteoforms from the Drosophila GSK-3 gene shaggy.

This study investigates caspase cleavage of Drosophila Sgg-PD proteoforms, revealing their role in cytoskeletal and cell junction regulation and unexpected retention of cleaved N-terminal domains.

Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells.

Wnt3 distribution in the zebrafish brain is determined by expression, diffusion and multiple molecular interactions

The paper investigates how Wnt3 spreads in the zebrafish brain through diffusion and molecular interactions, showing its binding to HSPG and Lrp5.

R-spondins are BMP receptor antagonists in early embryonic development

This study identifies R-spondins as BMP receptor antagonists, showing they inhibit BMP signaling via ZNRF3 and regulate dorsoventral axis formation in Xenopus embryos.

Alternative isoforms of KDM2A and KDM2B lysine demethylases negatively regulate canonical Wnt signaling

This study shows that alternative isoforms of KDM2A and KDM2B lysine demethylases negatively regulate canonical Wnt signaling by repressing target gene promoters and interacting with TCF7L1.

WSB1 Regulates c-Myc Expression Through β-catenin Signaling and Forms a Feedforward Circuit Promoting the Development of Cancer.

This study identifies a feedforward circuit between WSB1 and c-Myc that promotes cancer development through β-catenin signaling, suggesting a potential therapeutic target.

Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endodermal gene regulatory network

The paper identifies Sox17 and β-catenin interactions at enhancers that regulate endoderm gene expression and repression of mesectoderm fates during Xenopus gastrulation.

Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts

Frizzled-dependent Planar Cell Polarity without Wnt Ligands

The paper shows that Wnt ligands are not essential for Planar Cell Polarity (PCP) in Drosophila wings, as PCP remains normal in the absence of Wnt signaling.

TBX3 acts as tissue-specific component of the Wnt/β-catenin enhanceosome

The paper identifies TBX3 as a tissue-specific component of the Wnt/β-catenin enhanceosome, showing its role in transcriptional regulation and metastasis in colorectal cancer.