Immune Cell Function and Interaction

Effective allogeneic natural killer cell therapy for pancreatic adenocarcinoma avails conserved activating receptors and evades HLA I-driven inhibition

This study identifies key NK cell ligands on pancreatic adenocarcinoma that enable effective allogeneic NK cell therapy by evading HLA I inhibition.

PRDM1 Drives Chemoradiotherapy-associated Enrichment of Adaptive NK Cells in Cervical Cancer

This study identifies PRDM1 as a key regulator of adaptive NK cell enrichment and functional activation in cervical cancer following chemoradiotherapy.

A framework integrating multiscale in-silico modeling and experimental data predicts CD33 CAR-NK cytotoxicity across target cell types

The paper develops a multiscale computational model to predict CD33 CAR-NK cytotoxicity against various target cells using experimental data and flow cytometry.

Latent cytomegalovirus disrupts NK cell responses to P. falciparum and impairs parasite control

This study shows that latent cytomegalovirus infection reduces NK cell responses to Plasmodium falciparum and impairs parasite control by disrupting IL-12 production.

A Cellular Cytotoxicity Assay using Ready-to-Thaw Target Cells without Washing Steps

This paper develops a no-wash, ready-to-thaw cytotoxicity assay using cryopreserved target cells, showing it maintains viability and function without compromising results.

A Novel Natural Killer Cell Expansion Technology for the Development of Cellular Immunotherapies

This paper introduces a multifunctional fusion protein that enables efficient ex vivo expansion of NK cells from various sources and enhances their cytotoxic activity against tumor cells.

Using peptide-exchange systems to interrogate peptide-specific KIR binding to HLA Class -I

This study develops a peptide-exchange system to efficiently study KIR binding to HLA-I molecules with peptide specificity.

NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons

A patient-derived ovarian cancer organoid platform to study susceptibility to natural killer cells

The paper develops a live cell imaging assay using patient-derived ovarian cancer organoids to study natural killer cell-mediated apoptosis and identifies resistant organoid populations.

TIM-3 blockade enhances ex vivo stimulated allogeneic NK cell therapy for relapsed murine neuroblastoma after hematopoietic cell transplant

This study shows that combining TIM-3 blockade with ex vivo stimulated allogeneic NK cells improves survival and reduces tumor growth in a murine neuroblastoma model after allo-HCT without increasing GVHD.

NK cells undergo transcriptional and functional reprogramming following Streptococcus pneumoniae infection

This study uses single-cell RNA-seq to show that NK cells reprogram transcriptionally and functionally after Streptococcus pneumoniae infection, revealing new roles in bacterial immunity.

Interferon-mediated NK cell activation is associated with limited neutralization breadth during SARS-CoV-2 infection

The paper shows that NK cell activation during SARS-CoV-2 infection correlates with reduced neutralization breadth of antibodies.

Natural killer cell migration in HIV-infected individuals is inhibited by impairment of HIF-1alpha-mediated glycolysis

This study identifies that impaired NK cell migration in HIV-infected individuals is due to TIGIT inhibiting HIF-1-mediated glycolysis through PI3K/AKT/mTORC1 or ERK pathways.

FcεR1γ-based Activating Chimeric Antigen Receptors enhanced Natural Killer cell function against HLA-E+ cells

This study modifies FcεR1γ with a 4-1BB co-stimulatory motif to enhance NK cell function against HLA-E+ cells, improving cytotoxicity in suppression-prone conditions.

CLASP1/2 REGULATE IMMUNE SYNAPSE MATURATION IN NATURAL KILLER CELLS

This study shows that CLASP1/2 stabilize Golgi-derived microtubules in NK cells, facilitating LFA-1 trafficking and immune synapse maturation.

Expanded adaptive NKG2C+ NK cells exhibit potent ADCC and functional responses against HBV-infected hepatoma cell lines

This study expands adaptive NKG2C+ NK cells from HBV-infected donors, showing enhanced ADCC and anti-hepatoma activity.

Single-Cell Transcriptomics Reveals Dynamics of NK Cell Expansion in a Feeder Cell-Free Culture of PBMCs - Implications for Immunotherapy

This study uses single-cell transcriptomics to analyze NK cell expansion in PBMC cultures, identifying factors influencing donor variability and suggesting strategies to improve NK cell fraction and expansion.

Invariant Natural Killer T cells control positively and negatively the development of hepatocellular carcinoma

This study shows iNKT cells both promote and inhibit hepatocellular carcinoma (HCC) development, with their role shifting from early promotion to later tumor control.

STAT3 operates as an inflammation-dependent transcriptional switch

This study shows STAT3 acts as an inflammation-dependent transcriptional switch in NK cells, regulating differentiation through MYB and BLIMP-1 under different inflammatory conditions.

Single-cell neural network classifiers reveal that PM21 NK cell expansion is dependent on B cell signaling

The paper uses single-cell transcriptomics and neural network classifiers to identify B cell signaling as critical for NK cell expansion in allogenic therapy.

An atlas of natural killer cell receptor expression on healthy donor T and NK lymphocytes

The paper maps NK cell receptor expression on T and NK lymphocytes in healthy donors, revealing patterns linked to donor sex, maturation, and activation.

Zika virus induces persistent phenotypic changes in natural killer cells distinct from dengue virus infection

This study compares NK cell receptor expression in ZIKV and dengue-infected individuals, finding persistent phenotypic changes in ZIKV infection and virus-specific differences in NK cell activation.

Recognition of Ovarian Tumor-Derived Non-canonical Peptide Induces Memory-Like Features in Natural Killer Cells

This study identifies a non-canonical ovarian tumor peptide that induces memory-like features in NK cells through HLA-E engagement and receptor interaction.

NKp30 and NKG2D contribute to natural killer recognition of HIV-infected cells

This study identifies NKp30:B7-H6 and NKG2D:MICB/ULBP2 as receptor-ligand pairs that contribute to NK cell recognition of HIV-infected cells.

NKp46 Recognizes the Hyphal Form of Candida albicans and Mediates Protective Antifungal Immunity

This study identifies NKp46 as a receptor for hyphal forms of Candida albicans, showing its role in antifungal immunity through direct binding and functional effects.

Single-Cell Integration of Chromatin Accessibility and Transcriptomics Reveals Regulatory Networks in Ovarian Tumor-Infiltrating Adaptive NK Cells

This study integrates chromatin accessibility and transcriptomics data from ovarian tumor-infiltrating adaptive NK cells to identify key transcription factors and their regulatory networks.

Damage-induced IL-18 stimulates thymic NK Cells limiting endogenous tissue regeneration

This study shows that IL-18, generated in the thymus after tissue damage, limits thymic regeneration by targeting TECs, suggesting IL-18 as a therapeutic target and highlighting potential off-target effects in cancer immunotherapy.

Metabolic rewiring of cancer cells induces metastasis via ERK5 but triggers recognition by NK cells

This study shows that metabolic rewiring via fatty acid oxidation promotes cancer metastasis but also enhances NK cell recognition and killing of metastatic cells.

CD39 defines a cytotoxic tumor-associated NK cell state responsive to NKG2A blockade in lung cancer

The paper identifies CD39+ tumor-associated NK cells as a cytotoxic effector state in NSCLC responsive to NKG2A blockade through multiomic analysis.

ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation

This study shows ACLY supports NK cell effector functions by regulating glycolysis and histone acetylation, with acetate supplementation restoring these functions in ACLY-deficient cells.