Immune Cell Function and Interaction

Mapping human natural killer cell development in tonsil

This study maps human natural killer cell development in tonsil using single-cell analysis, showing spatial trajectories and tissue niches that support NK cell differentiation.

High KIR diversity in Uganda and Botswana children living with HIV

This study analyzes KIR diversity in HIV-infected children from Uganda and Botswana, finding differences in allele frequencies and associations with disease progression.

Interferon-γ promotes SMAP production by cytotoxic T lymphocytes in a thrombospondin 4 dependent manner

This study shows interferon-γ increases thrombospondin-4 expression in CTLs, promoting SMAP production and enhancing anti-tumor killing.

The HUSH Complex Dictates EBV-transformed B cell Sensitivity to NK Cell Surveillance Through Repression of NKG2A Ligand γ-Proto-cadherin

The paper identifies the HUSH complex as a regulator of EBV-transformed B cell sensitivity to NK cell surveillance by repressing the NKG2A ligand γ-protocadherin.

Towards understanding of NK cell antigenic specificity

The paper investigates NK cell antigenic specificity by analyzing scRNA-Seq, single-cell cloning, and in silico modeling to show glycosylation's role in modulating KIR2DS4 interactions with peptide-MHCI complexes.

Integrative Genomic, Single-Cell, and Functional Profiling of the CD48-CD244 Axis and NK-Cell Dysfunction in Multiple Myeloma

The paper investigates the CD48-CD244 axis in multiple myeloma, showing CD48 enhances NK-cell activation but contributes to NK exhaustion and poor prognosis.

Antibody Blockade of Ly49/MHC-I interactions enhances Innate and Adaptive Immunity Against Cancer Metastasis

This study shows that the anti-MHC-I antibody M1/42 enhances anti-tumor immunity by activating NK and adaptive immune cells, reducing metastasis in mouse models of cancer.

HLA-B51 induces IFN-γproduction in human natural killer cells

This study shows HLA-B51 activates human NK cells to produce IFN-γ, with KLRK1 as a key receptor, while IL-2 signals override HLA-B51 effects in some NK cell lines.

CMV Replication Drives IFNγ-Mediated Sensitization of AML Cells to Cytotoxic Killing Through the NKG2C-HLA-E Axis

The paper shows CMV replication increases IFNγ, which makes AML cells more vulnerable to NK cell killing via the NKG2C-HLA-E pathway.

PKA/CIP4 SIGNALING REGULATES CIP4 RELOCATION IN ACTIVATED NATURAL KILLER CELLS

This study identifies PKA/CIP4 signaling as a mechanism controlling CIP4 relocalization during NK cell activation, showing phosphorylation at T225 regulates its spatial distribution.

Feeder cell - the key component in producing scalable and fit NK cells for therapeutic use

This study evaluates engineered K562 feeder cells for enhancing NK cell expansion and function in ex vivo cultures, showing up to 500-fold higher yields compared to feeder-free systems.

CDK4/6 inhibition sensitizes breast cancer to NK cell therapy by inducing immune-interactive surface proteins

This paper shows CDK4/6 inhibitors make breast cancer cells more susceptible to NK cell therapy by increasing surface proteins that NK cells recognize.

Intratumoral expression of JAML on NK cells is controlled by tumor microenvironment and MHC class I interaction

The paper shows JAML expression on NK cells is regulated by tumor microenvironment and MHC class I interaction, with implications for NK cell-mediated tumor killing.

KIR*BLOOM: Accurate KIR genotyping using a new copy number-aware integrated genotype likelihood framework

KIR*BLOOM improves KIR genotyping accuracy by modeling copy number and sequencing errors, achieving high precision and recall on whole-genome sequencing data.

Loss of Vpr-driven TRAIL-R2 expression protects HIV-infected cells from non-canonical NK cell TRAIL attack

The paper shows HIV uses Vpr to increase TRAIL-R2 expression in CD4+ T cells, which enhances NK cell killing through non-canonical TRAIL signaling.

Multimodal immunopharmacologic screens identify drugs rewiring the cancer-immune interface

The paper identifies drugs that rewiring the cancer-immune interface by enhancing NK cell function and tumor susceptibility through multimodal screening approaches.

Enteroviral epitope mimicry enables NK cell-mediated targeting of ASPH in hepatocellular carcinoma

The paper identifies anti-CE1 antibodies that reduce HCC incidence and mortality by mediating NK cell ADCC against ASPH-expressing tumor cells through epitope mimicry.

Intra-Tumoral Treg Ablation Unleashes NK Cell-Mediated Control of CD8 T Cell-Resistant Tumors

Intra-tumoral Treg ablation enhances NK cell-mediated tumor control by restoring IL-2 production, effective against both MHC I+ and MHC I- cancers without systemic toxicity.

Glioblastoma-natural killer cell crosstalk: insights from dynamic spheroid models reveal the importance of secreted cytokines and the CD155 axis

This study uses dynamic 3D GB spheroids to investigate NK cell-GB crosstalk, identifying cytokine secretion and the CD155 axis as key factors in NK cell cytotoxicity against GB stem-like cells.

Safety and Feasibility of Infusing Ex Vivo Expanded Allogeneic Canine Natural Killer Cells for the Treatment of Metastatic Solid Tumors

This study expands and activates allogeneic canine NK cells ex vivo, demonstrating their safety and in vitro potency for treating metastatic solid tumors.

In vivo screening reveals new regulators of Natural Killer cell development and functional response to acute cytomegalovirus infection

The paper identifies novel regulators of NK cell development and antiviral function through in vivo screening in mice, with relevance to human health.

Age determines NK cell fate and tissue compartmentalization to CMV infection

The paper shows that NK cell responses to CMV infection differ between infants and adults, influenced by age and T cell immunity, with infant NK cells exhibiting adaptive-like features and tissue seeding.

LSD1 ablation promotes mammary tumor metastasis by attenuating NK cell-mediated anti-tumor immunity

This study shows that LSD1 ablation in mammary tumor cells reduces NK cell-mediated anti-tumor immunity, leading to increased lung metastasis.

Obesity-Driven Lung Lipidome Remodeling Suppresses NK Cell Activation and Antiviral Immunity to Influenza Infection

This study shows obesity remodels the lung lipidome, impairing NK cell function and antiviral immunity against influenza, and demonstrates that weight loss can restore these functions.

NK Cells Effectively Mediating Antibody-Mediated Kidney Allograft Rejection Requires a Specific Activation Receptor and Graft Expression of the Ligand

This study shows that NK cell activation via NKG2D and graft Rae-1e ligand is essential for antibody-mediated kidney allograft rejection, even with high DSA levels.

Tumor-infiltrating natural killer cell profiling for therapeutic stratification in patients with resectable non-small cell lung cancer

This study identifies smoking-associated natural killer cell subsets in NSCLC that correlate with survival and response to neoadjuvant chemoimmunotherapy, suggesting their use in therapeutic stratification.

Evaluating 6- and 18-hour stimulation durations for natural killer cell degranulation (CD107a assay) to optimize workflow efficiency in a clinical immunology laboratory

This study compares 6-hour and 18-hour stimulation durations for NK cell degranulation assays and finds the 6-hour protocol is more reliable and efficient.

Metabolic reinvigoration of NK cells by IL-21 enhances immunotherapy against MHC-I deficient solid tumors

This paper shows that IL-21-Fc reprograms NK cell metabolism to enhance their function against MHC-I deficient tumors, leading to tumor eradication in preclinical models.

Strength in Unity: a Dual Strategy to Restore NK Cell Cytotoxicity against Pancreatic Ductal Adenocarcinoma

This study develops and tests a dual strategy using NaMiX and TriKE to enhance NK cell cytotoxicity against PDAC, showing improved tumor cell killing in vitro and in humanized mouse models.

EBV Type 1 versus Type 2: A determinant of NK cell anti-tumor activity in Burkitt lymphoma

This study compares ADCC activity of CD56neg and CD56dim NK cells against EBV-type 1 and 2 Burkitt lymphoma cells, finding EBV-T2 cells are more susceptible to direct cytotoxicity.