B. Wang

Ploidy variation and spontaneous haploid-diploid switching of Candida glabrata clinical isolates

This study reports ploidy variation and spontaneous haploid-diploid switching in 500 clinical Candida glabrata isolates, revealing differences in morphology, antifungal susceptibility, virulence, and gene expression.

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

This study shows that ZBP1 and cGAS cooperate to detect mitochondrial DNA, leading to cardiotoxicity, and that blocking this interaction protects against heart damage.

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge

This study shows that peptide-poloxamine-DNA nanoparticles provide complete protection against lethal SARS-CoV-2 challenge through robust mucosal immunity.

Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms

This study shows that reversible activation of Jak2V617F in a mouse model demonstrates its essential role in myeloproliferative neoplasms and highlights the therapeutic potential of mutant-specific JAK2 inhibition.

Responses of Model Cortical Neurons to Temporal Interference Stimulation and Related Transcranial Alternating Current Stimulation Modalities

This study simulates TIS and related stimulation modalities on model cortical neurons to analyze E-field characteristics and neural responses, finding that TIS can cause conduction block and periodic activation at high E-field strengths.

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators

This study determines the structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators, revealing two distinct mechanisms to suppress channel activity.

Speed and correctness guarantees for programmable enthalpy-neutral DNA reactions

The paper develops a framework to analyze and guarantee speed and correctness in DNA strand displacement reactions, experimentally validating predictions about leak and toehold occlusion.

The tissue-specific chromatin accessibility landscape of Papaver somniferum

This study identifies tissue-specific chromatin accessibility and gene expression in Papaver somniferum to uncover regulatory mechanisms for morphine and noscapine accumulation.

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

High Bandwidth Power Electronics and Magnetic Nanoparticles for Multichannel Magnetogenetic Neurostimulation

The paper presents a power electronic system and magnetic nanoparticles enabling three-channel magnetogenetic neurostimulation with selective heating across different frequency ranges.

Coenzyme Q regulates UCP1 expression and thermogenesis through the integrated stress responses

This study shows that CoQ deficiency in BAT activates the ISR and suppresses UCP1, yet increases whole-body metabolic rates and reduces weight gain on HFD.

Oligomer-to-Monomer Transition Underlies the Chaperone Function of AAGAB in AP1/AP2 Assembly

This study identifies the dual role of AAGAB's tetramerization domain in stabilizing AAGAB and binding substrates during AP1/AP2 complex assembly.

Allosteric interactions prime androgen receptor dimerization and activation

This study identifies allosteric interactions that prime androgen receptor dimerization and activation, revealing structural and functional mechanisms relevant to development and disease.

Proteomics and Functional Analysis Revealed TaGSTU6/TaCBSX3 Enhances Wheat Resistance to Powdery Mildew

Proteomics identified differences in wheat resistance to Pst and Bgt, with TaGSTU6/TaCBSX3 interaction specifically enhancing resistance to Bgt.

Reconstitution of the S. aureus agr quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis

This study identifies MroQ as the second protease in the S. aureus agr quorum sensing pathway, showing its role in AIP biosynthesis and revealing molecular features guiding its cleavage activity.

Mapping the allosteric effects that define functional activity of SARS-CoV-2 specific antibodies

This study identifies site-specific allosteric effects in SARS-CoV-2 Spike protein induced by different neutralizing antibodies, revealing dynamic features that distinguish weak from strong neutralizers.

Biological characteristics of two mesenchymal stem cell lines isolated from the umbilical cord and adipose tissue of a neonatal common hippo (Hippopotamus amphibius)

This study isolates and characterizes two mesenchymal stem cell lines from a neonatal common hippo, showing their fibroblastoid morphology, normal karyotype, and stemness markers, with distinct differentiation potentials.

Broad and Long-lasting Immune Response against SARS-CoV-2 Omicron and Other Variants by PIKA-Adjuvanted Recombinant SARS-CoV-2 Spike (S) Protein Subunit Vaccine (YS-SC2-010)

This study shows that the PIKA-adjuvanted SARS-CoV-2 spike protein vaccine YS-SC2-010 maintains high neutralizing activity against Omicron and other variants for up to 596 days post-vaccination in animal serum.

Changes of small non-coding RNAs by severe acute respiratory syndrome coronavirus 2 infection

This study identifies changes in small non-coding RNAs (sncRNAs) in SARS-CoV-2 infection, showing that tRFs and a viral-derived sncRNA (sv-CoV2-346) are significantly altered.

Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity

This study profiles healthy human kidney cells from 19 donors to reveal sex-based transcriptional differences and tissue-specific immune features.

Intestinal SEC16B modulates obesity by controlling dietary lipid absorption

This study shows that intestinal SEC16B is essential for dietary lipid absorption, with its loss protecting mice from obesity.

A modified porous silicon microparticle promotes mucosal delivery of SARS-CoV-2 antigen and induction of potent and durable systemic and mucosal T helper 1 skewed protective immunity

Identification of a promiscuous conserved CTL epitope within the SARS-CoV-2 spike protein

The paper identifies a conserved CTL epitope in the SARS-CoV-2 spike protein that is compatible with most HLA alleles and suitable for evaluating CD8+ T cell responses.

Global Mutational Sweep of SARS-CoV-2: from Chaos to Order

The paper analyzes SARS-CoV-2 genome sequences to show mutation sweeps driven by emerging variants, which may prolong the pandemic and challenge control efforts.

A novel cryo-electron microscopy support film based on 2D crystal of HFBI protein

This paper introduces a new cryo-EM support film using HFBI protein 2D crystals to improve protein structure resolution by reducing preferred orientation and denaturation during vitrification.

Direct precise measurement of the stall torque of the flagellar motor in E. coli

This study directly measures the stall torque of E. coli flagellar motors using magnetic tweezers, finding each stator unit passes 2 protons per step.

The endoplasmic reticulum adopts two distinct tubule forms

The paper identifies two distinct ER tubule forms, R1 and R2, regulated by Rtn4 and Climp63, with functional implications for ER structure and dynamics.

Diversity, function and evolution of marine microbe genomes

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.

SCARECROW maintains the stem cell niche in Arabidopsis root by ensuring telomere integrity

This study identifies SCARECROW's role in maintaining telomere integrity and genome stability in Arabidopsis root stem cells through regulation of TEN1 and related factors.