Neurogenesis and neuroplasticity mechanisms

Generation of human cerebral organoids with a structured outer subventricular zone

This study generates human cerebral organoids with a structured outer subventricular zone by activating the STAT3 pathway with LIF, mimicking in vivo oRG development and enhancing neuronal maturation.

Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis

This study uses three-photon imaging to show that white matter generates more oligodendrocytes than gray matter, but gray matter shows faster growth rates and regenerative deficits after injury.

Junctional Adhesion Molecule (JAM)-C recruitment of Pard3 and drebrin to cell contacts initiates neuron-glia recognition and layer-specific cell sorting in developing cerebella.

This study shows that JAM-C on cerebellar granule neurons interacts with glial cells to recruit Pard3 and drebrin, enabling cell sorting and layer-specific positioning during cerebellar development.

Spatial enhancer activation determines inhibitory neuron identity

The paper shows that MEIS2 and DLX5 activate enhancers for projection neurons, while LHX6 represses them in interneurons, and a MEIS2 mutation linked to intellectual disability impairs this process.

Pervasive environmental chemicals impair oligodendrocyte development

This study identifies two classes of environmental chemicals that impair oligodendrocyte development through distinct mechanisms and links exposure to adverse neurodevelopmental outcomes.

Single cell approaches define forebrain neural stem cell niches and identify microglial ligands that enhance precursor-mediated remyelination

The paper uses single-cell RNA-sequencing and spatial transcriptomics to study forebrain neural stem cell niches and identifies microglial ligands that enhance remyelination.

Autofluorescence is a biomarker of neural stem cell activation state

The paper uses autofluorescence imaging to identify and track neural stem cell activation states in vitro and in vivo, linking it to transcriptional features and cell behavior.

The ciliary kinesin KIF7 controls the development of the cerebral cortex by acting differentially on SHH-signaling in dorsal and ventral forebrain

This study shows that KIF7 deletion in mice disrupts cerebral cortex development by altering SHH signaling differently in dorsal and ventral forebrain regions, leading to structural and migratory defects in neurons.

Primate-expressed EPIREGULIN promotes basal progenitor proliferation in the developing neocortex

This study shows that primate-specific EPIREGULIN expression enhances basal progenitor proliferation in the developing neocortex, contributing to increased brain size across species.

Prosaposin maintains adult neural stem cells in a state associated with deep quiescence

This study identifies Prosaposin as a regulator of neural stem cell quiescence in zebrafish, showing it maintains deep quiescence and reduces activation.

Cerebellar granule cell migration and folia development requires Mllt11/Af1q/Tcf7c

This study identifies Mllt11's role in cerebellar granule cell migration and folia development, showing its impact on neuronal organization and cytoarchitecture.

The bidirectional role of GABAA and GABAB receptors during the differentiation process of neural precursor cells of thesubventricular zone

This study investigates how taurine, acting through GABAA and GABAB receptors, influences neuronal differentiation and electrophysiological properties of mouse subventricular zone neural precursor cells.

ERK signaling drives evolutionary expansion of the mammalian cerebral cortex

This study identifies ERK-BMP7-GLI3R signaling in cortical radial glial cells as a driver of mammalian cerebral cortex expansion, with implications for evolutionary dwarfism in mice.

NFIB influences progenitor competence in maturation of GABAergic neurons in mice

The paper investigates how progenitor competence influences GABAergic neuron maturation in mice using single-cell transcriptomics and chromatin profiling, finding that NFIB regulates maturation competence in late-born neurons.

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination

This study identifies SRF as a transcriptional regulator of cytoskeletal genes in oligodendrocytes essential for myelination during development.

Midbrain Dopaminergic Neuron Development is Regulated by Two Molecularly Distinct Subtypes of Radial Glia Cells

The paper identifies two distinct radial glia subtypes in the developing midbrain and shows their different roles in dopaminergic neuron development using human stem cells.

Human neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression

This study shows glucocorticoids increase specific basal progenitors via ZBTB16, leading to more neurons and linking to educational attainment and brain structure.

Orderly specification and precise laminar deployment of cortical glutamatergic projection neuron types through intermediate progenitors

The paper shows that intermediate progenitors generate projection neuron types in a non-sequential manner, challenging the inside-out model of cortical layering.

Manipulation of the Nuclear Envelope-Associated Protein SLAPDuring Mammalian Brain Development Affects Cortical Lamination and Exploratory Behavior

This study shows that manipulating SLAP expression during brain development affects cortical lamination and exploratory behavior in mice.

Genetic labeling of embryonically-born dentate granule neurons in young mice using the PenkCre mouse line

This study evaluates the PenkCre mouse line as a tool to label and study embryonically-born dentate granule neurons in young mice.

Importin 13-dependent Axon Diameter Growth Regulates Conduction Speeds along Myelinated CNS Axons

The paper identifies importin 13b's role in axon diameter growth and shows its impact on conduction velocity in myelinated axons in zebrafish.

HB-EGF and EGF infusion following CNS demyelination mitigates age-related decline in regeneration of oligodendrocytes from neural precursor cells originating in the ventricular-subventricular zone

This study shows that infusing HB-EGF and EGF into aged mice improves oligodendrocyte regeneration from NPCs after CNS demyelination.

Identity and Nature of Neural Stem Cells in the Adult Human Subventricular Zone

This study creates a cell atlas of the adult human subventricular zone using single-cell transcriptomics, identifying multipotent neural stem cells and their lineage potential.

The Role of Nde1 Phosphorylation in Interkinetic Nuclear Migration and Schizophrenia

This study investigates the role of Nde1 phosphorylation in interkinetic nuclear migration and schizophrenia by analyzing phosphomutants in rat brains.

Oligodendrocyte maturation alters the cell death mechanisms that cause demyelination

This study shows that oligodendrocyte maturation changes cell death mechanisms, with precursor cells dying quickly and mature cells dying slowly after genotoxic damage.

Neuronal-class specific molecular cues drive differential myelination in the neocortex

The paper identifies neuron-class specific signals that drive differential myelination across cortical layers using single-cell data from mouse neocortex.

Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus

This study shows that Kdm6b is essential for establishing and maintaining neural stem cells in the mouse hippocampus, with loss of Kdm6b leading to defective neurogenesis and cognitive impairments.

Schwann cells have a limited window of time in which to initiate myelination program during early migration in vivo

The paper shows that Schwann cells must initiate myelin signaling during a specific time window in vivo, and missing this window prevents myelination.

In vivo timelapse imaging and analysis of Golgi satellite organelle distribution and movement in the neural progenitor cells of the brain

The paper uses in vivo timelapse imaging to study Golgi satellite movement in neural progenitor cells of Xenopus laevis tadpoles, revealing dynamic distribution of these organelles.

Loss of Ezh2 in the medial ganglionic eminence alters interneuron fate, cell morphology and gene expression profiles

This study shows that loss of Ezh2 in the medial ganglionic eminence (MGE) leads to changes in interneuron fate, morphology, and gene expression.