Neurogenesis and neuroplasticity mechanisms

Developmental landscape of human forebrain at a single-cell level unveils early waves of oligodendrogenesis

This study identifies an early wave of oligodendrogenesis in the human forebrain at PCW 8 using single-cell RNA-Seq and ATAC-Seq, supported by spatial gene expression analysis.

Extrinsic regulation of interneuron specification and migration

The paper shows that extracellular environment factors, specifically extracellular vesicles, influence neuronal differentiation and migration by altering transcriptomic profiles in neural progenitor cells.

Neurogenesis mediated plasticity is associated with reduced neuronal activity in CA1 during context fear memory retrieval

This study shows that increased adult hippocampal neurogenesis reduces CA1 neuronal activity during context fear memory retrieval and alters perineuronal net expression, potentially leading to memory forgetting.

BMAL1 loss in oligodendroglial lineage cells dysregulates myelination and sleep

The paper shows BMAL1 regulates oligodendroglial maintenance and myelination, which affects sleep, and links this to MS pathology.

Snip1 and PRC2 coordinate intrinsic apoptosis, cell division, and neurogenesis in the developing brain

This study identifies Snip1 as a regulator of neural progenitor cell fates by interacting with PRC2 to control apoptosis, cell division, and neurogenesis in the developing mouse brain.

Somatic mosaicism in the mature brain reveals clonal cellular distributions during cortical development

The paper evaluates brain somatic mosaicism in the adult human to identify rules governing cellular distribution during embryogenesis.

Astrocyte-mediated transduction of muscle fiber contractions synchronizes hippocampal neuronal network development

The paper shows that contracting muscle conditioned media accelerates hippocampal neuronal maturation and astrocyte proliferation, with astrocytes mediating the effects on neuronal activity.

DOT1L activity affects cell lineage progression in the developing brain by controlling metabolic programs

This study shows that DOT1L activity regulates AP lineage progression in the developing mouse neocortex by controlling metabolic programs and gene expression.

Can neurogenesis act as a neural regularizer?

This paper investigates whether neurogenesis acts as a regularizer in neural networks, finding it enhances generalization in a category learning task.

Less is more - loss of EGFL7 improves memory by upregulation of VEGF-D

This study shows that loss of EGFL7 enhances memory by increasing VEGF-D, which promotes adult neurogenesis and improves memory consolidation in mice.

Oral and injected tamoxifen alter adult hippocampal neurogenesis in female and male mice

This study compares the efficiency and effects of tamoxifen injection versus chow administration in inducing recombination and altering adult hippocampal neurogenesis in mice.

Cortical integration of higher-order thalamic inputs is lineage-dependent

The paper shows that cortical neurons integrate higher-order thalamic inputs based on their lineage, with apical intermediate progenitor-derived neurons exhibiting specific response properties and dependency on Lhx2.

Unmyelinated neurons use Neuregulin signals to promote myelination of neighboring neurons in the CNS

The paper identifies nrg1 type II as a regulator of myelination in zebrafish spinal cord neurons, showing unmyelinated neurons signal to myelinate circuit partners.

Single-cell analyses of axolotl forebrain organization, neurogenesis, and regeneration

This study uses single-cell genomics to analyze axolotl forebrain cell types, neurogenesis, and regeneration, identifying conserved neuron classes and injury responses.

Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43

This study shows that TDP-43 loss affects oligodendrocyte survival and myelination differently at various stages of maturation, leading to morphological defects and neurological impairments.

Persistent postnatal migration of interneurons into the human entorhinal cortex

This study shows that interneurons continue to migrate into the human entorhinal cortex postnatally, with distinct lineage contributions and maturation patterns identified using single-nuclei RNAseq.

Synapses and Ca2+ activity in oligodendrocyte precursor cells can predict where myelin sheaths form

The paper identifies postsynaptic molecules in OPCs and shows their role in predicting myelin sheath formation through Ca2+ activity.

Clemastine induces an impairment in developmental myelination

This study shows clemastine increases oligodendrocyte differentiation but impairs myelination during development, likely due to microglia-oligodendrocyte interactions.

Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of secretory proteins

The paper identifies VGF as a thalamus-derived factor essential for maintaining layer 4 neuron numbers in mouse sensory cortices, highlighting thalamocortical axons' role in shaping cortical cytoarchitecture through area-specific secretory protein supply.

A distinct subset of oligodendrocyte lineage cells interact with the developing dorsal root entry during its genesis

The paper identifies a distinct oligodendrocyte lineage cell interacting with dorsal root ganglia sensory neurons during development and shows its role in sensory behavior.

Vangl2, a core component of the WNT/PCP pathway, regulates adult hippocampal neurogenesis and age-related decline in cognitive flexibility

This study shows that Vangl2 regulates adult hippocampal neurogenesis and cognitive flexibility in mice, with reduced Vangl2 leading to impaired memory and increased interference-based forgetting.

Ependymal cell maturation is heterogeneous and ongoing in the mouse spinal cord and dynamically regulated in response to injury

This study profiles adult mouse spinal cord ependymal cells using single-cell RNA-sequencing, revealing a new mature state and dynamic maturation regulation in response to injury.

Pinch2 is a novel regulator of myelination in the Central Nervous System

This study identifies Pinch2 as a critical regulator of central nervous system myelination, showing that its loss leads to hypermyelination and pathological myelin outfoldings.

Oligodendrocyte Precursor Cells Sculpt the Visual System by Regulating Axonal Remodeling

This study shows that oligodendrocyte precursor cells regulate axonal remodeling in the zebrafish visual system without forming myelin, affecting visual acuity.

Selective Requirement for Polycomb Repressor Complex 2 in the Generation of Specific Hypothalamic Neuronal Sub-types

This study shows that while most hypothalamic neurons develop normally without the H3K27me3 epigenetic mark, specific neuronal subtypes are sensitive to its loss.

Pax6 loss alters the morphological and electrophysiological development of mouse prethalamic neurons

This study shows that Pax6 loss affects neurite extension, axon initial segment properties, and electrophysiological function in developing mouse prethalamic neurons.

A lateral protrusion latticework connects neuroepithelial cells and is regulated during neurogenesis

The paper identifies and characterizes lateral protrusions in neuroepithelial cells, showing they form a latticework regulated by WAVE1 and are involved in neurogenesis.

Diversification of multipotential postmitotic mouse retinal ganglion cell precursors into discrete types

This study uses single-cell RNA-seq to show that mouse retinal ganglion cell precursors diversify into discrete types through gradual fate restriction after mitosis.

Human spinal cord differentiation proceeds rapidly in vitro and only initially maintains differentiation pace in a heterologous environment

This study shows that human spinal cord differentiation in vitro is faster than in vivo and stalls when grafted into a different species, highlighting the role of extrinsic signals.

Combined single-cell RNA-seq profiling and enhancer editing reveals critical spatiotemporal controls over thalamic nuclei formation in the murine embryo

The paper uses single-cell RNA-seq and enhancer editing to study thalamic nuclei formation in mice, revealing lineage-specific gene expression programs and their role in neurodevelopmental disorders.