Genetics, Aging, and Longevity in Model Organisms

The F-box protein FBXL-5 governs vitellogenesis and lipid homeostasis in C. elegans

This study identifies FBXL-5 as a negative regulator of vitellogenesis and lipid homeostasis in C. elegans, revealing its role in an SCF ubiquitin-ligase complex interacting with mTORC2 signaling.

The Gehan test identifies life-extending compounds overlooked by the log-rank test in the NIA Interventions Testing Program: Metformin, Enalapril, caffeic acid phenethyl ester, green tea extract, and 17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride.

The paper reanalyzes ITP data using the Gehan test, identifying 5 compounds that extend mouse lifespan, missed by the log-rank test.

An optogenetic assay for the dauer decision in Caenorhabditis elegans

The paper develops an optogenetic assay to study the dauer decision in C. elegans, showing that ASJ neuron activity influences dauer exit.

An intestinal Sir2-HSF1-ATGL1 pathway regulates lipolysis in C. elegans

The paper identifies an intestinal pathway in C. elegans where SIR-2.1 and HSF-1 regulate lipolysis through ATGL-1, showing context-specific interactions and implications for stress resilience and aging.

Dietary restriction reveals sex-specific expression of the mTOR pathway genes in Japanese quails

This study examines sex-specific changes in mTOR pathway gene expression in Japanese quails under dietary restriction, finding differential effects between males and females.

Plasma-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems

The paper uses machine learning on plasma proteome data to develop organ-specific and conventional aging models, showing that age-related diseases reflect accelerated aging of specific organs and systems.

The Neuron-specific IIS/FOXO Transcriptome in Aged Animals Reveals Regulatory Mechanisms of Neuronal and Cognitive Aging

This study investigates the IIS/FOXO pathway's role in cognitive aging using C. elegans, finding that daf-2 mutants exhibit distinct transcriptomic changes that enhance neuronal resilience.

Evidence of a pan-tissue decline in stemness during human aging

The paper assigns stemness scores to human tissues using machine learning and finds a general decline in stemness with age, except in the uterus, and links stemness to proliferation and senescence.

Transiently restricting individual amino acids protects D. melanogaster against multiple stressors

The paper shows that restricting individual amino acids, particularly isoleucine, in Drosophila melanogaster increases resistance to multiple stressors, including nicotine, oxidative stress, and cold shock.

A diet of oxidative stress-adapted bacteria improves stress resistance and lifespan in C. elegans via p38-MAPK.

This study shows that C. elegans fed oxidative stress-adapted bacteria live longer and are more stress-resistant due to activation of the p38-MAPK pathway.

Endogenous hydrogen peroxide positively regulates secretion of a gut-derived peptide in neuroendocrine potentiation of the oxidative stress response in C. elegans

The paper identifies a gut-brain axis mechanism in C. elegans where intestinal hydrogen peroxide regulates neuropeptide secretion to enhance the oxidative stress response.

Dietary restriction and life-history trade-offs: insights into mTOR pathway regulation and reproductive investment in Japanese quails

This study examines how dietary restriction affects mTOR pathway gene expression and reproductive investment in Japanese quails, showing reduced mTOR and IGF1 expression with increased autophagy-related genes under restriction.

Desynchrony between events triggers a compensatory delay during C. elegans development

The paper shows that reduced insulin signaling in C. elegans delays cell divisions more than molting, increasing desynchrony and triggering a compensatory delay in the molting program.

pyaging: a Python-based compendium of GPU-optimized aging clocks

pyaging provides a Python package with over 30 aging clocks for analyzing molecular data types across species, using GPU-optimized models for efficient inference.

MANIPULATING MITOCHONDRIAL REACTIVE OXYGEN SPECIES ALTERS SURVIVAL IN UNEXPECTED WAYS IN A DROSOPHILA MODEL OF NEURODEGENERATION

This study manipulates mitochondrial reactive oxygen species in a Drosophila neurodegeneration model and finds that increased H2O2 correlates with improved survival, while drug effects depend on treatment timing, duration, and genotype.

A defined diet for pre-adult Drosophila melanogaster

This paper introduces an adjusted diet formula for Drosophila melanogaster larvae to improve growth, development, and survival, with applications in studying metabolic disorders.

Aberrant neuronal hyperactivation causes an age- and diet-dependent decline in associative learning behavior

This study shows that increased neuronal activity in aging C. elegans impairs associative learning behavior, which can be mitigated by dietary changes.

Machine learning predicts lifespan and underlying causes of death in aging C. elegans

The paper uses machine learning to predict lifespan and causes of death in aging C. elegans by analyzing senescent pathology and genetic factors.

Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging

This study shows that mitochondrial stress in GABAergic neurons of C. elegans non-cell-autonomously affects lifespan, stress tolerance, and reproduction.

Dietary Restriction Fails to Extend Lifespan of Drosophila Model of Werner Syndrome

This study shows that dietary restriction does not extend the lifespan of Drosophila WS model flies and may even be detrimental, suggesting a role for the WRN exonuclease domain in metabolism.

The peroxiredoxin Tsa1 extends the lifespan of budding yeast by maintaining the stability of the ribosomal RNA gene cluster.

This study shows that Tsa1 stabilizes the rDNA cluster in budding yeast, preventing rDNA instability and extending lifespan.

The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans

This study identifies SET-26 and HCF-1 as factors that antagonize HDA-1 to regulate gene expression and longevity in C. elegans.

Neuronal IL-17 controls C. elegans developmental diapause through CEP-1/p53

This paper shows that neuronal IL-17 signaling in C. elegans controls developmental diapause by regulating CEP-1/p53 activity, linking nutrient availability to cell cycle progression and metabolic changes.

Protection against APOE4-associated aging phenotypes with the longevity-promoting intervention 17α-estradiol in male mice

This study shows that 17α-estradiol improves aging outcomes in APOE4 mice more than APOE3 mice, suggesting a genotype-dependent benefit of the intervention.

Cell non-autonomous control of autophagy and metabolism by glial cells

This study shows glial cells control autophagy and metabolism in C. elegans through non-autonomous activation of HLH-30 in the intestine.

Inhibition of S6K lowers age-related inflammation and immunosenescence and increases lifespan through the endolysosomal system

This study shows that inhibiting S6K in Drosophila and mice reduces age-related inflammation and extends lifespan through the endolysosomal system and immune pathways.

On standardization of controls in lifespan studies

This paper identifies issues in lifespan studies due to lack of standardization and proposes solutions for improving data consistency and comparability.

Differential Responses of Dynamic and Entropic Aging Factors to Longevity Interventions

The paper identifies two DNAm aging signatures in mice, one exponential and one linear, showing differential responses to longevity interventions like caloric restriction and parabiosis.

A VHL-1/HIF-1/SQRD1/COL-88 axis links extracellular matrix formation with longevity in Caenorhabditis elegans

This paper identifies a VHL-1/HIF-1/SQRD-1/COL-88 axis linking extracellular matrix formation with longevity in C. elegans, showing that loss of VHL-1 increases lifespan and alters collagen expression.

Non-cell-autonomous regulation of germline proteostasis by insulin/IGF-1 signaling via the intestinal peptide transporter PEPT-1

The paper shows that insulin/IGF-1 signaling regulates germline proteostasis in C. elegans by promoting dietary protein absorption through the intestinal transporter PEPT-1.