Genetics, Aging, and Longevity in Model Organisms

GCN2 mediates access to stored amino acids for somatic maintenance during Drosophila ageing

This study shows GCN2-mediated autophagy allows Drosophila to use stored amino acids for somatic maintenance during dietary deprivation, extending lifespan.

Developmental disruption of the mitochondrial fissiongene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant

This study shows that disrupting the mitochondrial fission gene drp-1 during development extends the lifespan of daf-2 mutants by improving mitochondrial function and stress resistance.

Roles of progranulin and FRamides in neural versus non-neural tissues on dietary restriction-related longevity and proteostasis in C. elegans

This study investigates the role of progranulin and FMRFamide-like neuropeptides in longevity and proteostasis under dietary restriction in C. elegans, finding no major effects on lifespan but increased motility in specific contexts.

The neurohormone tyramine stimulates the secretion of an Insulin-Like Peptide from the intestine to modulate the systemic stress response in C. elegans

This study identifies INS-3 as a key insulin-like peptide modulated by tyramine that influences stress resistance and reproductive development in C. elegans.

Longitudinal Fragility phenotyping predicts lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice

This study uses frailty phenotyping to predict lifespan and age-associated morbidity in mice, finding it has significant predictive power but not sufficient reliability for advanced lifespan prediction.

The ACE-inhibitor drug captopril inhibits ACN-1 to control dauer formation and aging

The paper shows captopril extends lifespan in worms and mice by inhibiting ACN-1, which regulates dauer formation and interacts with daf genes.

Daily Activity Profiles over the Lifespan of Female Medflies as Biomarkers of Aging and Longevity

This study examines daily activity patterns in female Mediterranean fruit flies and links them to lifespan, diet, and age-at-death.

UPRER-immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food

The paper identifies the UPRER-immunity axis as a physiological system that evaluates food quality and promotes aversion to low-quality food.

Heat Shock Proteins Function as Signaling Molecules to Mediate Neuron-Glia Communication During Aging

The paper identifies a novel neuron-glia communication mechanism involving heat shock proteins transmitted via extracellular vesicles, which activate glial pathways to protect against aging-related decline.

Experimental variables that impact outcomes in Caenorhabditis elegans aging stress response

This study identifies experimental variables affecting stress response outcomes in C. elegans aging research and proposes standardized guidelines to improve reproducibility.

Longevity interventions in Titan mice attenuate frailty and senescence accumulation

This study shows that dietary intervention and senolytic drug treatment reduce frailty and senescence in Titan mice, making them a useful model for studying longevity interventions.

Optimising age-specific insulin signalling to slow down reproductive ageing increases fitness in different environments

The paper shows that optimizing insulin signaling in adulthood improves late-life reproduction and fitness in C. elegans across different environments.

A pair of RNA binding proteins inhibit ion transporter expression to maintain lifespan

The paper identifies an ion transporter gene, nhx-6, as a causative target of RNA binding proteins exc-7 and mbl-1, whose inhibition extends lifespan in C. elegans.

A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons

The paper identifies drh-1 as a mechanism to counteract excessive SKN-1 transcriptional activity in C. elegans, improving healthspan by opposing age-related pathology.

Male-specific features of C. elegans neuronal aging

This study identifies sex-dimorphic neuronal aging features in C. elegans males and hermaphrodites, revealing differential gene expression and X-chromosomal dysregulation associated with cognitive decline.

A non-canonical role of somatic CYCLIN D/CYD-1 in oogenesis and reproductive aging, dependent on the FOXO/DAF-16 activation state

This study shows that CYCLIN D/CYD-1 in somatic tissues interacts with FOXO/DAF-16 to regulate oogenesis and reproductive aging in C. elegans.

Probiotic bacteria Lacticaseibacillus rhamnosus L108 and Lacticaseibacillus delbrueckii R2 increase lifespan and influence the expression of Caenorhabditis elegans longevity genes

Repeated Activation of Gαq by neurotransmitters causes age-dependent accumulation of stress granules in C.elegans

This study shows that repeated Gαq activation in C. elegans leads to stress granule accumulation and age-dependent neuronal defects, reducing lifespan.

Integrated Multi-Omics Analysis of Brain Aging in Female Nonhuman Primates Reveals Altered Signaling Pathways Relevant to Age-Related Disorders

The paper integrates multi-omics data from female baboons to identify age-related molecular changes in the prefrontal cortex, revealing altered signaling pathways and potential biomarkers for age-related cognitive decline.

Epithelial cells of the intestine acquire cell-intrinsic inflammation signatures during ageing

This study shows that aged intestinal epithelial cells exhibit a persistent inflammation signature, marked by MHC class II upregulation and increased chromatin accessibility of inflammation-associated loci.

Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4- and RMD9-dependent mechanisms

This study identifies YBR238C as a regulator of cellular aging in yeast, showing it modulates mitochondrial function through HAP4 and RMD9, and links TORC1 activity to mitochondrial feedback loops affecting aging.

SHC-3: a previously unidentified C. elegans Shc family member functions in the insulin-like signaling pathway to enhance survival during L1 arrest

Gain of function in linc-133 compensates for daf-18/PTEN loss and rescues survival

The paper shows that linc-133 gain of function compensates for daf-18 loss by restoring survival in C. elegans through protein homeostasis mechanisms.

Transcriptome analysis of different strains of the turquoise killifish Nothobranchius furzeri identifies signatures associated with heritable lifespan differences

Tissue-specific overexpression of the double-stranded RNA transporter SID-1 limits lifespan in C. elegans

This study shows that tissue-specific overexpression of SID-1 in C. elegans reduces lifespan, implicating systemic RNA transport in lifespan regulation.

3-phenyllactic acid promotes healthspan through SKN-1/ATFS-1-mediated mitochondrial activation and stress resilience

This study identifies 3-phenyllactic acid (PLA) as a metabolite from lactic acid bacteria that extends healthspan in C. elegans by enhancing mitochondrial function and stress resilience, and links PLA levels to sarcopenia in humans.

Transcriptomic reprogramming screen identifies SRSF1 as rejuvenation factor

This study identifies SRSF1 as a rejuvenation factor through transcriptomic reprogramming, showing it improves cellular function and is linked to longevity.

Sterility-Independent Enhancement of Proteasome Function via Floxuridine-Triggered Detoxification in C. elegans

This study shows that floxuridine enhances proteasome function in C. elegans, improves cold survival, and activates a detoxification pathway independent of SKN-1 and the germline.

Screening and characterization of aging regulators using synthesized yeast chromosome XIII

The paper constructs a synthetic yeast chromosome and identifies aging regulators through replicative lifespan studies and genome-scale analysis.

Cell age drives asynchronous transcriptome aging

The paper investigates how cell-specific turnover rates influence transcriptome aging across organs and develops a model to explain differential aging rates.