multiome

Neighboring codon adjacent nucleotides have a conserved influence on mRNA decay

The paper investigates how codon usage and context affect mRNA decay rates in Arabidopsis, finding that codon optimality explains 21% of decay rate variance and that codon context also influences stability.

RNMT is recruited to RNA by interaction with RNA G-quadraplexes

This study identifies RNMT's direct interaction with RNA G-quadruplexes, revealing a mechanism for gene-specific cap methylation during RNA processing.

A Multi-Omic Atlas of Convergent and Divergent Metabolic Regulatory Circuitries in Cancer

This study develops a multi-omic framework to map convergent and divergent metabolic regulatory circuitries across cancers, revealing context-dependent regulatory patterns.

Viral protease-Initiated Pyroptosis Activator mRNA therapy as a Universal Antiviral Strategy

This paper develops VIPA mRNA therapy, which uses viral protease-initiated pyroptosis to suppress viral replication and elicit immune responses in animal models.

A Pan-Cancer Blueprint of Early Tumor Microenvironment Reprogramming

The paper integrates multi-omics data from 14 cancers to reveal early metabolic and transcriptional reprogramming in the tumor microenvironment, identifying key genes and pathways involved.

Engineering temporal alignment of mRNA delivery enables functional rescue across genetic infertility models

This study identifies temporal mismatch between mRNA delivery and spermatogenesis as a barrier to functional rescue, showing that sustained expression aligned with developmental timing enables recovery in genetic infertility models.

Chemical inhibition of Exon Junction Complex assembly impairs mRNA localization and neural stem cells ciliogenesis

This study shows that inhibiting EJC assembly with EJC-i disrupts mRNA localization and neural stem cell ciliogenesis by affecting multiple post-transcriptional processes.

Deep Generative Optimization of mRNA Codon Sequences for Enhanced mRNA Translation and Therapeutic Efficacy

RiboDecode generates optimized mRNA codon sequences using deep learning, improving protein expression and therapeutic efficacy in vitro and in vivo.

PRC2 Restricts Malignant Peripheral Nerve Sheath Tumorigenesis in a Genetically Engineered Mouse Model of MPNST

This study shows that PRC2 inactivation promotes MPNST by reprogramming Schwann-lineage cells and presents a mouse model that recapitulates human PRC2-loss MPNST.

Anti-CD38-Targeted Piperazine-Derived Lipid Nanoparticles Overcome Hepatic Clearance for mRNA Delivery to Multiple Myeloma Cells In Vivo

This study develops anti-CD38 lipid nanoparticles for targeted mRNA delivery to multiple myeloma cells, improving tumor targeting and reducing hepatic accumulation.

Hydroxychloroquine decouples reactogenicity from efficacy in mRNA and viral-vector gene delivery

This study shows hydroxychloroquine reduces inflammation from mRNA and viral-vector therapies without affecting their therapeutic effectiveness.

Signal-Level Witnessing of SU(1,1) Pair Dynamics in Brain Proton Spin Ensembles

The paper identifies SU(1,1) pair dynamics in brain proton spin ensembles using a symmetry-based framework and reanalysis of magnetic-resonance data.

Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications

The paper describes improvements in diffusion MRI processing for the HBCD study, introducing new software and observing developmental patterns in brain data.

Hox-Meis-relayed gene regulatory transition underlies cardiopharyngeal neural crest diversification

The paper maps lineage trajectories and gene regulatory networks of cardiopharyngeal neural crest cells in mice, identifying a Hox-Meis-regulated transition associated with cardiac cushion development.

RNA splicing is required for timely completion of abscission and is modulated by the abscission checkpoint

The paper investigates the role of RNA splicing factors in abscission checkpoint maintenance and identifies a unique RNA landscape associated with ACB formation.

KHSRP-mediated Decay of Axonally Localized Prenyl-Cdc42 mRNA Slows Nerve Regeneration

The paper shows that KHSRP-mediated decay of axonal Prenyl-Cdc42 mRNA slows nerve regeneration by regulating mRNA stability and transport in response to growth signals.

SynOmics: Integrating Multi-omics Data Through Feature Interaction Networks

SynOmics improves multi-omics integration by modeling feature interactions through a graph convolutional network, outperforming existing methods in biomedical classification tasks.

A kinetic ruler controls mRNA poly(A) tail length

The paper identifies a kinetic ruler mechanism where Nab2 protein concentration determines mRNA poly(A) tail length through competition between polyadenylation and RNA-binding.

Modified self-amplifying RNA mediates robust and prolonged gene expression in the mouse and ex vivo human brain

This paper demonstrates that modified self-amplifying RNA (saRNA) enables long-lasting protein expression in mouse and human brain tissues.

On the replicability of diffusion weighted MRI-based brain-behavior models

This paper evaluates the replicability of diffusion-weighted MRI-based brain-behavior models and finds moderate replicability with small sample sizes, but higher replicability for trait-like phenotypes.

CaMKII-RNMT axis directs activity-dependent control of RNA dynamics in neurons

This study identifies the CaMKII-RNMT axis as a mechanism controlling activity-dependent RNA dynamics and neuronal morphogenesis through phosphorylation and degradation of RNMT.

Small Extracellular Vesicles from Radioresistant H3K27M-Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response

This study shows that sEVs from radioresistant H3K27M-pDMG cells protect radiosensitive cells from radiation by altering metabolism and DNA repair.

DDX3X acts as a selective dual switch regulator of mRNA translation in acute ER stress

The paper identifies DDX3X as a dual switch regulator of mRNA translation, promoting or suppressing translation in non-stressed cells and switching roles in acute ER stress.

A dual genetic constraint underlies the conservation of early brains in vertebrates.

This paper integrates five vertebrate single-cell multi-omic atlases to reveal a conserved cellular blueprint and dual evolutionary constraints underlying early brain conservation across vertebrates.

Non-invasive prediction of conduction velocities in the human brain from MRI-derived microstructure features at 7 Tesla

This paper develops a whole-brain model to predict conduction velocity from MRI-derived microstructural features, explaining 29% of variance in neurophysiological conduction velocity.

Single-cell multiomics data integration and generation with scPairing

scPairing generates multiomics data from single cells using deep learning, capturing biological structures and enabling trimodal data creation.

Mammalian ZAP and KHNYN can independently restrict CpG-enriched avian viruses

The paper shows mammalian ZAP and KHNYN can restrict CpG-enriched avian viruses, with human ZAP or KHNYN independently limiting CpG-enriched IAV in chicken and human cells.

Engineering Linear Cap-independent mRNA Vaccines with Intrinsic Adjuvanticity for Potent Cancer Immunotherapy

This paper develops a cap-independent mRNA vaccine platform that enhances antitumor immunity through intrinsic adjuvanticity and improved in vivo expression.

Simulated Solute Tempering 2: An Efficient and Practical Approach to Protein Conformational Sampling and Binding Events

This paper introduces SST2, a new enhanced sampling method for molecular dynamics simulations that improves efficiency for large biomolecular systems by selectively scaling interactions within and around the molecule.

Sexually distinct multi omic responses to progressive endurance exercise training in the rat lung. Findings from MoTrPAC

This study identifies sex-specific multi-omic responses to endurance exercise training in rat lungs, revealing differences in immune pathways and mitochondrial acetylation between males and females.