Mitochondrial Function and Pathology

Inherited mitochondrial dysfunction triggered by OPA1 mutation impacts the sensory innervation fibre identity, functionality and regenerative potential in the cornea

This study shows that OPA1 mutation causes corneal innervation issues, including reduced sensitivity and impaired regeneration, despite normal epithelial function.

Heterogeneous brain region-specific responses to astrocytic mitochondrial DNA damage in mice

This study shows brain-region-specific differences in astrocytic responses to mitochondrial DNA damage using a novel AAV-based tool in mice.

Mfn2 promotes NCLX-mediated Ca2+ release from mitochondria

This study identifies Mfn2's role in promoting NCLX-mediated Ca2+ release from mitochondria, linking mitochondrial ROS to mitophagy via Ca2+ signaling.

Disruption of mitochondrial folate metabolism leads to mitochondrial DNA leakage and activation of apoptotic or inflammatory pathways

This study shows that reduced Shmt2 expression causes mtDNA leakage into the cytosol, triggering different downstream effects like apoptosis or activation of the cGAS/STING pathway in different cell types.

The role of the synaptic vesicle protein SV2A in regulating mitochondrial morphology and autophagy.

This paper identifies SV2A as a mitochondrial outer membrane protein that regulates mitochondrial morphology and autophagy through interactions with DRP1 and ATG9A.

MitoNEET reduces the mitochondrial oxidative phosphorylation during epithelial-mesenchymal transition

This study shows that mitoNEET downregulation during EMT impairs OXPHOS and cell motility in mouse mammary epithelial cells.

Single-Mitochondrion Sequencing Uncovers Distinct Mutational Patterns and Heteroplasmy Landscape in Mouse Astrocytes and Neurons.

The paper analyzes mtDNA SNVs in single mitochondria from mouse neurons and astrocytes, revealing cell-type-specific mutation patterns and purifying selection.

Cardiolipin remodeling maintains the inner mitochondrial membrane in cells with saturated lipidomes

This study shows that cardiolipin remodeling is essential for maintaining inner mitochondrial membrane structure in yeast under low oxygen conditions and identifies Ddl1p as a regulator of CL levels.

The guardians of mitochondrial dynamics: a novel role for intermediate filament proteins

The paper identifies ITPRIPL2 as a novel protein involved in mitochondrial dynamics through computational interaction analysis and shows its role in vimentin-associated intermediate filament structure.

Lactate-carried Mitochondrial Energy Overflow

The paper investigates mitochondrial lactate metabolism, finding that mitochondria produce lactate as an overflow mechanism to regulate redox levels and conserve energy.

Structural diversity of mitochondria in the neuromuscular system across development

The paper studies mitochondrial structural diversity in C. elegans neuromuscular system across development using 3D electron microscopy and deep learning, finding correlations between mitochondrial properties and synaptic connections, and identifying stage-specific mitochondrial features in dauer.

Protein-Induced Membrane Strain Drives Supercomplex Formation

This study shows that mitochondrial supercomplex formation reduces membrane strain and enhances allosteric crosstalk, with implications for OXPHOS efficiency.

Amino acids trigger MDC-dependent mitochondrial remodeling by altering mitochondrial function

The paper shows amino acids trigger MDC-dependent mitochondrial remodeling by altering mitochondrial metabolism and TCA cycle metabolite levels.

Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease

The paper identifies repurposable drugs for mitochondrial disease by using deep learning to screen for compounds that improve neuronal commitment and neurogenesis in Leigh syndrome organoids.

NCLX controls hepatic mitochondrial Ca2+ extrusion and couples hormone-mediated mitochondrial Ca2+ oscillations with gluconeogenesis

This study identifies NCLX as the primary mitochondrial Ca2+ extruder in hepatocytes, linking hormone-mediated mitochondrial Ca2+ oscillations to gluconeogenesis.

Simple prerequisite of presequence for mitochondrial protein import in the unicellular red alga Cyanidioschyzon merolae

The paper investigates mitochondrial protein import in Cyanidioschyzon merolae by designing synthetic targeting peptides and showing that basic residues and specific amino acid composition are sufficient for import, with a simplified authentication mechanism involving TOM22.

Vertebrates show coordinated elevated expression of mitochondrial and nuclear genes after birth: a conserved metabolic switch

The paper identifies a conserved post-birth metabolic switch in vertebrates characterized by elevated mitochondrial and nuclear gene expression across multiple tissues.

Changes in mitochondrial distribution occur at the axon initial segment in association with neurodegeneration in Drosophila

The paper investigates mitochondrial distribution changes in Drosophila neurodegeneration, finding altered mitochondrial localization at the axon initial segment associated with reduced Cdk5 activity.

Compositionally unique mitochondria in filopodia support cellular migration

The paper identifies METEORs, mitochondria specialized for filopodia, and shows their role in supporting cellular migration.

Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

Time-resolved mitochondrial-focused screening identifies regulatory components of oxidative metabolism

This study uses CRISPR/Cas9 screening to identify novel regulators of mitochondrial oxidative metabolism, revealing key genes involved in complex I assembly and BCAA catabolism.

Effects of time-dependent ATP consumption caused by neuron firing on ATP concentrations in synaptic boutons containing and lacking a stationary mitochondrion

This paper models ATP concentration dynamics in presynaptic boutons with and without stationary mitochondria, finding that ATP levels remain sufficient for synaptic activity even without mitochondria.

Age-specific and compartment-dependent changes in mitochondrial homeostasis and cytoplasmic viscosity in mouse peripheral neurons

This study investigates age-related changes in mitochondrial function and cytoplasmic viscosity in mouse peripheral neurons, finding compartment-specific effects on mitochondrial trafficking and homeostasis.

Nanobiopsy investigation of the subcellular mtDNA heteroplasmy in human tissues

This study uses nanobiopsy and next-generation sequencing to assess subcellular mtDNA mutation loads in human tissue from mitochondrial disease patients.

Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes

This study shows that Drp1-mediated mitochondrial fragmentation ensures symmetric organelle partitioning and faithful chromosome segregation in mouse zygotes.

Increase in ER-mitochondria contacts and mitochondrial fusion are hallmarks of mitochondrial activation during embryogenesis

The paper profiles mitochondrial activity, morphology, and associated molecular changes during zebrafish embryogenesis, identifying increased ER-mitochondria contacts and mitochondrial fusion as key contributors to mitochondrial activation.

Neuronal activity inhibits axonal mitochondrial transport in a region-specific manner

The paper shows that neuronal activity inhibits axonal mitochondrial transport in specific axonal regions during realistic firing patterns, but not in non-connecting segments.

Structure of the II2-III2-IV2 mitochondrial supercomplex from the parasite Perkinsus marinus

This study determines the structure of a unique II2-III2-IV2 mitochondrial supercomplex from Perkinsus marinus using cryo-EM, revealing novel subunit arrangements and functional features.

Biochemical and neurophysiological effects of deficiency of the mitochondrial import protein TIMM50

This study investigates the effects of TIMM50 deficiency in human fibroblasts and mouse neurons, finding reduced mitochondrial function and altered potassium channel levels linked to neurological symptoms.

Germline status and micronutrient availability regulate a somatic mitochondrial quality control pathway via short-chain fatty acid metabolism

This study shows that germline signals regulate somatic mitochondrial quality control through short-chain fatty acid metabolism and micronutrient availability in C. elegans.