Cancer Cells and Metastasis

A human lung organoid co-culture model of early bone sarcoma metastasis reveals contact-dependent epithelial remodeling at the metastatic interface

This paper introduces a 3D co-culture model of bone sarcoma metastasis in the lung and identifies a contact-dependent epithelial remodeling response with potential therapeutic targets.

TGF-β1-induced differentiation enhances chemotherapy response in metastatic colorectal cancer organoids

This study shows that TGF-β1-induced differentiation in colorectal cancer organoids enhances chemotherapy response by reducing clonogenic capacity and increasing oxaliplatin cytotoxicity.

EMT associated transcription factors Slug and Snail demonstrate specific expression patterns in breast cancer subtypes, involving tumor or stroma components and correlating with proliferation status and complex clinical prognosis.

This study examines the expression patterns of Slug and Snail in breast cancer subtypes, linking their expression to proliferation status and clinical outcomes.

Cross-Cancer Profiling of Cadherin-1 Reveals Context-Dependent Epithelial-Mesenchymal Transition Decoupling, Immune Heterogeneity, and Prognostic Variability in Epithelial Cancers

This study profiles CDH1 across multiple cancers, revealing context-dependent prognostic significance, EMT relationships, immune heterogeneity, and methylation patterns.

TUMOR HETEROGENEITY AND STEMNESS CAN BE SHAPED BY MECHANO-STRUCTURAL PARAMETERS IN OSTEOSARCOMA

This study shows that softer, anisotropic niches promote OS-CSC properties, including chemoresistance and tumorigenicity, through transcriptional and epigenetic changes.

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

This study identifies developmental programmes driving cellular plasticity in lung adenocarcinoma, linking BM activation to poor prognosis and therapy resistance.

Multidimensional Cellular Micro-Compartments to Model Invasive Lobular Carcinoma Dormancy

This study develops multidimensional in vitro models to investigate anti-estrogen resistance and dormancy in invasive lobular carcinoma, identifying p27Kip1 signaling as central to dormant phenotype.

ETS1 Orchestrates a Hybrid EMT Program Driving in vivo Metastasis and Immune Evasion

This study identifies ETS1 as a master regulator of a hybrid EMT program in UASCC that drives metastasis and immune evasion, and shows HSP90 inhibitors can target ETS1-driven tumors.

Restoration of E-cadherin Expression Alters Metastatic Organotropism in Invasive Lobular Breast Carcinoma Models

This study shows that restoring E-cadherin in ILC models reduces metastasis to specific organs but has limited effects on primary tumor growth and 2D cell growth.

SOX9 and SEMA7A regulate cell plasticity in the postpartum mammary gland with implications for breast cancer

This study identifies SOX9 and SEMA7A as regulators of cell plasticity in postpartum mammary glands and links their dysregulation to breast cancer progression and metastasis.

Cellular stemness identifies high-risk ductal carcinoma in situ and offers a therapeutic interception opportunity

This study identifies stemness features in luminal hormone-responsive cells within DCIS that correlate with invasive progression and shows that targeting FOXA1 reduces tumor growth.

Direct interaction between cancer cells and fibroblasts promotes early chemoresistance to standard-of-care drug therapy in small cell lung cancer (SCLC)

This study shows direct contact between SCLC cells and fibroblasts causes early chemoresistance to etoposide and cisplatin, with idarubicin remaining effective.

Keratin 5 marks cancer-propagating cells sustained by an osteopontin-producing niche in high-grade serous ovarian carcinoma

This study identifies KRT5-expressing cells as cancer-propagating cells in HGSC that depend on an OPN-producing niche for survival and chemoresistance.

PTHrP drives aggressive traits in colorectal cancer cells: Implications of tumor-stromal cells

This study shows PTHrP enhances CRC aggressiveness by modulating Met receptor and TGFβ1 signaling in tumor-stromal interactions.

Dedifferentiation-Driven Oncogenic Stemness Promotes Tumor-Sustaining Adaptability in the Intestinal Epithelium

This study shows dedifferentiation-derived oncogenic stem cells sustain intestinal tumorigenesis more effectively than mutant stem cells, with aberrant Notch signaling and metabolic plasticity contributing to tumor growth.

Cell fusion reprograms tumor cells and promotes RUNX1-mediated invasion and dissemination in colorectal cancer

This study identifies RUNX1 as a key driver of tumor-immune hybrid cell invasion and dissemination in colorectal cancer, highlighting circulating hybrid cells as a biomarker for metastasis.

Enforced ZFP281 expression delays breast cancer initiation and can provide lifelong protection against breast cancer metastasis

This study shows that ZFP281 expression delays breast cancer initiation and prevents metastasis by enforcing a dormant state in cancer cells.

Suppression of PP2A-B56α Drives EMT in EGFR Mutant Non-Small Cell Lung Cancer

This study shows that suppressing PP2A-B56α promotes EMT in EGFR mutant NSCLC by reducing epithelial markers and increasing mesenchymal markers, leading to migratory and invasive phenotypes.

Brief report on the development of patient-derived lung cancer organoids with keratinizing squamous cell carcinoma morphology

This paper develops patient-derived lung cancer organoids that replicate histological features of keratinizing squamous cell carcinoma, offering a tool for studying tumor biology and drug testing.

EMT and cell cycle control invadopodia and metastasis in breast cancer via Filip1L

The paper identifies FILIP1L as a key regulator linking EMT, cell cycle, and invadopodia in breast cancer, showing its role in ECM degradation and metastasis.

Integrated analysis of stemness-associated immune modulatory circuits in squamous cell carcinomas

The paper identifies SOX2 as a master regulator of immune modulatory circuits in tumor-initiating stem cells, enabling immunosuppressive myeloid cell development.

Chemotherapy reshapes cellular clonal landscape via persister programs in breast cancer xenografts

This study shows chemotherapy reshapes clonal architecture in breast cancer xenografts by selecting for chemotherapy-resistant clones and stress response programs.

Selection for targeted therapy resistance leads to an indirect selection for higher phenotypic plasticity and enhanced evolvability to orthogonal stressors

The paper shows that targeted therapy resistance in cancer selects for cells with higher phenotypic plasticity, which enhances their ability to adapt to other stressors and promotes metastasis.

Reprogramming breast cancer cells to breast cancer stem cell-like by the POU1F1 transcription factor

This study shows POU1F1 reprograms breast cancer cells into BCSC-like by altering key markers and activating the IL-6/JAK2/STAT3 pathway, suggesting therapeutic targeting of this pathway in hormone therapy-resistant tumors.

Advanced models of lobular breast cancer metastasis capture clinical organ tropism, endocrine response, and bone remodeling

This study develops a metastatic ILC mouse model to study organ tropism, endocrine response, and bone remodeling in mILC.

An in vitro model of breast cancer metastatic niche priming

This paper develops an in vitro model to study metastatic niche priming and interactions between primary and metastatic sites in breast cancer.

An Organotypic Oral Squamous Cell Carcinoma Model Recapitulates Epithelial-Stromal Complexity at Single-cell Resolution and Reveals Matrix-derived Signalling as a Therapeutic Target.

This paper develops an organotypic HNSCC model that captures epithelial-stromal complexity and identifies matrix-derived signals as therapeutic targets.

Plasticity of squamous differentiation drives drug resistance in HNSCC

This study shows that some HNSCC cells resist differentiation despite being capable of it, highlighting a barrier to differentiation-based therapies.

Androgen receptor activation stabilizes a hybrid epithelial/mesenchymal phenotype in presence of Notch-Jagged signaling

The paper develops a mathematical model showing that Androgen Receptor stabilizes a hybrid epithelial/mesenchymal phenotype in prostate cancer cells with Notch-Jagged signaling, correlating with worse patient outcomes.

Patient-derived organoids from malignant pleural effusion to explore for alternative therapies in thoracic tumors

This study generates patient-derived organoids from malignant pleural effusions to assess chemotherapy sensitivity in thoracic tumors, revealing significant inter-model variability in treatment response.