Neurogenesis and neuroplasticity mechanisms

IDENTIFICATION OF AN EARLY SUBSET OF CEREBELLAR NUCLEI NEURONS IN MICE

The paper identifies a novel subset of cerebellar nuclei neurons in mice that originate from an extrinsic germinal zone, distinct from the rhombic lip and ventricular zone.

NEUROG2 regulates a human-specific neurodevelopmental gene regulatory program

The paper identifies NEUROG2's role in regulating a human-specific gene regulatory program in neural progenitor cells through transcriptomic analysis of knock-in organoids.

Her9 controls the stemness properties of the hindbrain boundary cells

This study identifies Her9's role in maintaining hindbrain boundary cells as proliferative progenitors by inhibiting neurogenesis and promoting symmetric divisions.

Human stem cell-derived GABAergic interneuron development reveals early emergence of subtype diversity followed by gradual electrochemical maturation

The paper develops human MGE-pINs from pluripotent stem cells and shows their maturation into SST and PVALB subtypes with functional and molecular characteristics.

KIF3C Regulates Bergmann Glia Density and Patterning during Cerebellar Development

This study shows KIF3C is essential for cerebellar development through regulating Bergmann glia density and patterning, independent of Hedgehog signaling.

Generating human neural diversity with a multiplexed morphogen screen in organoids

This study uses a morphogen screen in human neural organoids to generate diverse neural cell types and uncover design principles of brain region specification.

The Nucleoporin Nup153 Is the Anchor for Kif1a during Basal Nuclear migration in Brain Progenitor Cells

The paper identifies Nup153 as the anchor for Kif1a during G1-phase basal nuclear migration in radial glial progenitor cells, completing the model for interkinetic nuclear migration.

Purinergic Receptor P2Y13 Controls Activation and Mode of Division in Subependymal Adult Neural Stem Cells

This study identifies P2Y13 as a key regulator of NSC activation and division mode in the adult SEZ, distinguishing quiescent from activated NSCs and influencing self-renewal versus differentiation.

Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons and heterogeneity

The paper identifies four V1 interneuron clades in the spinal cord based on birthdate, lineage, and connectivity, showing functional differences in their synaptic connections and circuit roles.

MYT1L deficiency impairs excitatory neuron trajectory during cortical development

This study examines the role of MYT1L in neuronal development by analyzing gene expression in wild-type and MYT1L-deficient mice, finding disruptions in excitatory neuron proportions and gene expression.

Embryonically generated interneurons (EGINs) exhibit a distinctive developmental program and lamination in the olfactory bulb

The paper investigates embryonically generated interneurons in the mouse olfactory bulb, showing their distribution, developmental timing, and distinct lamination patterns.

Switching of RNA splicing regulators in immature neuroblasts: a key step in adult neurogenesis

The paper identifies an immature neuroblast population with plasticity and molecular switches in splicing regulators during neurogenesis.

Marcks and Marcks-like 1 proteins promote spinal cord development and regeneration in Xenopus

This study shows Marcks and Marcksl1 proteins are essential for spinal cord development and regeneration in Xenopus, with some functions mediated by PLD signaling.

Non-apoptotic caspase events and Atf3 expression underlie direct neuronal differentiation of adult neural stem cells

Pharmacogenomic screening identifies and repurposes leucovorin and dyclonine as pro-oligodendrogenic compounds in brain repair

This paper identifies leucovorin and dyclonine as pro-oligodendrogenic compounds through pharmacogenomic screening and validates their therapeutic potential in mouse models of myelin pathologies.

Timely neurogenesis enables increased nuclear packing order during neuronal lamination

The paper shows that nuclear shape changes and packing order during neurogenesis are critical for retinal lamination in zebrafish.

Neural stem and progenitor cells support and protect adult hippocampal function via vascular endothelial growth factor secretion.

This study shows that adult hippocampal NSPCs secrete VEGF, which supports and protects hippocampal function independently of neurogenesis.

How serially homologous neuroblasts produce different temporal cohorts along the Drosophila larval body axis

This study shows how a single neural stem cell type generates segment-specific lineages by producing different temporal cohorts through variations in division patterns and post-mitotic mechanisms.

Molecular signatures of cortical expansion in the human fetal brain

The paper presents a 3D digital atlas of the human fetal brain at 21 weeks gestation, revealing molecular signatures of cortical expansion linked to neurogenesis timing and evolutionary boundaries.

Targeted H3K9 acetylation at lncSox1 promoter by cell type-specific epigenome editing promotes intermediate progenitor proliferation in developing mouse cortex

Cspg4 sculpts oligodendrocyte precursor cell morphology

This study shows that Cspg4 regulates oligodendrocyte precursor cell morphology in zebrafish without affecting myelin sheath production.

FGF8-mediated gene regulation affects regional identity in human cerebral organoids

This study shows FGF8 signaling influences regional identity and cellular diversity in human cerebral organoids, affecting neural progenitor fate and genes linked to neurodevelopmental disorders.

IL-17A Alters Human Cortical Development in a 3D Ex Vivo Model of Maternal Immune Activation

The paper shows IL-17A disrupts human cortical development in a 3D ex vivo model of maternal immune activation by altering neurogenesis and ECM pathways.

Transcriptional profiles of murine oligodendrocyte precursor cells across the lifespan

This study investigates how aging affects oligodendrocyte precursor cells (OPCs) by analyzing their transcriptional profiles across the lifespan using single-cell RNA sequencing.

Dispensable regulation of brain development and myelination by the immune-related protein Serpina3n

This study investigates the role of Serpina3n in postnatal brain development and myelination, finding it dispensable under homeostatic conditions but involved in oxidative stress responses.

Olduvai domains downregulate mitochondrial pathways to promote human brain evolution and neoteny

This study shows Olduvai domains suppress mitochondrial pathways, delaying cellular maturation and promoting brain size increase in humans.

Molecular Specification of Claustro-Amygdalar and Paleocortical Neurons and Connectivity

This study identifies SOX4, SOX11, and TFAP2D as critical regulators of ventropallial excitatory neuron development and PFC connectivity in mice, with conserved roles in humans.

RSPO/LGR signaling mediates astrocyte-induced proliferation of adult hippocampal neural stem cells

This study identifies RSPO/LGR signaling as a mechanism by which astrocytes regulate proliferation of adult hippocampal neural stem cells through Wnt signaling.

Spatial transcriptomic analysis of adult hippocampal neurogenesis in the human brain

The paper uses spatial transcriptomics and FISH to analyze adult hippocampal neurogenesis in the human dentate gyrus across ages, finding few neural stem cell markers but significant DCX expression with mixed inhibitory and excitatory phenotypes.

Microglia attenuate regenerative neurogenesis via sema4ab after spinal cord injury in zebrafish

This study shows that sema4ab in microglia suppresses regenerative neurogenesis after spinal cord injury in zebrafish by altering microglia activation and fibroblast cytokine expression.