Neurogenesis and neuroplasticity mechanisms

Gene regulatory mechanisms guiding bifurcation of inhibitory and excitatory neuron lineages in the anterior brainstem

The paper investigates gene regulatory mechanisms controlling the differentiation of inhibitory GABAergic and excitatory glutamatergic neurons in the anterior brainstem using chromatin accessibility and transcription factor analysis.

Tet3 Mediates O-GlcNAcylation-Induced Remyelination

This study identifies O-GlcNAcylation as a driver of remyelination, with Tet3 as a key downstream effector that modulates demethylation and myelin gene expression.

Transient upregulation of procaspase-3 during oligodendrocyte fate decisions

The paper identifies transient procaspase-3 upregulation in differentiating oligodendrocytes and shows its role in promoting differentiation and survival decisions.

Multi-Region Brain Organoid: Fusion Organoid with Cerebral, Endothelial and Mid-Hindbrain Components

This paper introduces Multi-Region Brain Organoids (MRBOs) that integrate cerebral, mid/hindbrain, and complex endothelial components, revealing new roles for endothelial cells in brain development.

A human-specific, concerted repression of microcephaly genes contributes to radiation-induced growth defects in forebrain organoids

The paper shows that radiation-induced DNA damage in human forebrain organoids leads to microcephaly through a human-specific p53-E2F4 repression of microcephaly genes.

Primate-specific microRNA-1202 regulates dopaminergic neurogenesis by targeting APC2 and modulates WNT/β-catenin signaling pathway in midbrain organoid

Transcriptional Landscape of THAP9 across Oligodendrocyte Developmental Stages: Molecular Mechanisms and Network Analysis

This study identifies THAP9 as a human-specific regulator of oligodendrocyte maturation through transcriptomic analysis of human oligodendrocyte progenitor cells and mature oligodendrocytes.

NUBP2 deficiency disrupts the centrosome-check point in the brain and causes primary microcephaly

This study identifies NUBP2 deficiency as a cause of primary microcephaly by showing its role in centrosome and cilia regulation during neurogenesis.

Incomplete remyelination via endogenous or therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function

This study shows that partial oligodendrocyte restoration after demyelination is sufficient to recover visual cortical function in mice.

Cellular signalling protrusions enable dynamic distant contacts in spinal cord neurogenesis

The paper investigates how cellular protrusions in mouse spinal cord neural progenitors enable long-distance Notch signaling, affecting HES5 expression patterns.

AUTS2, a causative gene for microcephaly, regulates division of intermediate progenitor cells and production of upper-layer neurons

This study identifies AUTS2's role in regulating intermediate progenitor cell division and upper-layer neuron production through interaction with PRC2 and repression of genes like Robo1.

Spatio-temporal dynamics of macroglial cell organisation and proximity to blood vessels during postnatal development

This study examines the spatial organization and proximity of macroglial cells to blood vessels during postnatal brain development, revealing distinct developmental patterns for astrocytes and oligodendrocytes.

Perdurant TTC21B protein in the early mouse embryo is required for proper forebrain neural progenitor proliferation.

This study shows that Ttc21b is essential for forebrain neural progenitor proliferation and differentiation in mice, leading to microcephaly due to disrupted cell cycle and cytoskeletal defects.

Audiovisual gamma stimulation enhances hippocampal neurogenesis and neural circuit plasticity in aging mice

This study shows that audiovisual gamma stimulation improves hippocampal neurogenesis and circuit plasticity in aging mice by enhancing progenitor cell activity and synaptic integration.

Developmental axon diameter growth of central nervous system axons does not depend on ensheathment or myelination by oligodendrocytes

This study shows that CNS axon diameter growth does not require oligodendrocyte ensheathment or myelination, contrasting with PNS findings.

Development of catecholaminergic neurons of Otp-lineage in the medial extended amygdala and other centers of the social behavior network

The paper investigates the origin of catecholaminergic neurons in the medial extended amygdala and related brain regions using Otp-eGFP mice and immunofluorescence.

Mechanical cues stabilize a conserved morphometric state associated with radial glia-like competence across systems

The paper shows mechanical cues induce nuclear remodeling linked to radial glia-like competence across species, using a model based on nuclear geometry and cell density.

Endogenous gene tagging with FnCas9 to track and sort neural lineages from 3D cortical organoids

This study uses FnCas9 to generate fluorescently labeled hESC lines for tracking and sorting neural lineages in 2D cultures and 3D cortical organoids.

Functional Equivalence of the Proneural Genes Neurog1 and Neurog2 in the Developing Dorsal Root Ganglia Highlights the Importance of Timing of Neurogenesis in Biasing Somatosensory Precursor Fates

The paper shows Neurog1 and Neurog2 are functionally equivalent in DRG development, with neuronal fate determined by neurogenesis timing rather than TF identity.

Two independent translocation modes drive neural stem cell dissemination into the human fetal cortex

The paper identifies two translocation modes for human fetal neural stem cells, showing that interphasic somal translocation (IST) accounts for 85% of their movement during cortical colonization.

Modeling the acutely injured brain environment in vitro.

This study develops an in vitro model of brain injury that recapitulates key features of injury and regeneration, enabling the study of glia-to-neuron reprogramming and stem cell dynamics.

Reactivation of a dormant developmental plasticity program drives synaptic rejuvenation and antidepressant-like responses

This study shows that fluoxetine reactivates a dormant developmental plasticity program in mature neurons, leading to synaptic rejuvenation and antidepressant-like effects.

miR-126 modulates neural progenitor cell development

This study shows miR-126 regulates neural progenitor cell differentiation by targeting IGF1R pathway genes and affects motor neuron development.

Genetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal Activity

This study generates a genetically labeled premyelinating oligodendrocyte mouse line to study their morphology, transcriptomics, and role in axon ensheathment and neuronal activity.

Phylogenetic variation of immature neurons in mammalian amygdala: high prevalence in primate expanded nuclei projecting to neocortex

The paper examines immature neurons in the amygdala across eight mammalian species, finding greater prevalence in primates, suggesting a link to complex socio-cognitive functions.

Cytoplasmic expression of the cell cycle regulator cyclin D1 in radial glial progenitor cells modulates brain cortex development

This study identifies a cytoplasmic function of cyclin D1 in radial glial progenitor cells that regulates cortical layering independent of cell cycle regulation.

WWOX deficiency impairs neurogenesis and neuronal function in human organoids

This study identifies WWOX mutations' impact on neurogenesis and neuronal function in human organoids, showing gene therapy can restore function.

Mouse brain organoids model in vivo neurodevelopment and function and capture differences to human

This study develops protocols for generating mouse brain organoids that mimic in vivo neurodevelopment and function, showing they closely resemble in vivo models across multiple readouts.

Neuronal expression of E2F4DN restores adult neurogenesis in homozygous 5xFAD mice via TrkB signaling

This study shows that neuronal expression of E2F4DN restores adult neurogenesis in 5xFAD mice by enhancing TrkB signaling in neural stem cells.

Axonal selectivity of myelination by single oligodendrocytes established during development in mouse cerebellar white matter

The paper shows that oligodendrocytes selectively myelinate Purkinje cell axons in the mouse cerebellar white matter, with this preference established during development.