Neurogenesis and neuroplasticity mechanisms

Building functional circuits in multispecies brains.

This study uses interspecies neural blastocyst complementation to build and test functional rat-mouse neural circuits in rat-mouse brains, showing synaptic activity and partial behavioral rescue.

Lifelong regeneration of cerebellar Purkinje neurons after induced cell ablation in zebrafish

This study shows that zebrafish cerebellar Purkinje neurons can regenerate throughout life after induced cell ablation, restoring function and behavior.

Foxp- and Skor-family proteins control differentiation of Purkinje cells from Ptf1a and Neurogenin1-expressing progenitors in zebrafish

This study identifies Foxp1b/4 and Skor1b/2 as key transcriptional regulators controlling Purkinje cell differentiation from ptf1a/neurogenin1-expressing progenitors in zebrafish.

A population of gray matter oligodendrocytes directly associates with the vasculature

The paper investigates the interaction between mature oligodendrocytes and blood vessels in the mouse brain, finding that ~17% of oligodendrocytes are in contact with capillaries and suggesting a role in vascular microenvironment.

Connexin 43-mediated Neurovascular Interactions Regulate Neurogenesis in the Adult Brain Subventricular Zone

This study shows that Cx43-mediated interactions between neural stem cells and endothelial cells in the SVZ regulate NSC quiescence and neurogenesis.

A network of Notch-dependent and -independent her genes controls neural stem and progenitor cells in the zebrafish thalamic proliferation zone

The paper identifies Notch-dependent and -independent her genes in zebrafish thalamic proliferation zones, showing their roles in NSC maintenance and progenitor transition.

Role of pioneer neurons and neuroblast behaviors on otic ganglion assembly

The paper investigates how pioneer neurons and neuroblast behaviors contribute to the 3D organization of the statoacoustic ganglion in zebrafish.

Oligodendrocytes in human iPS cell-derived cortical grafts remyelinate adult rat and human cortical neurons

This study shows human iPS cell-derived oligodendrocytes can remyelinate adult rat and human cortical neurons in vitro and in vivo.

A miR-124-mediated post-transcriptional mechanism controlling the cell fate switch of astrocytes to induced-neurons

This study shows miR-124 can drive astrocyte-to-neuron reprogramming independently, by targeting Zfp36l1 and enhancing neurogenic pathways, with ISX9 improving efficiency and maturation.

Pyruvate dehydrogenase dependent metabolic program affects oligodendrocyte maturation and remyelination

This study shows that pyruvate dehydrogenase (Pdh) activity is critical for oligodendrocyte maturation and remyelination by regulating mitochondrial respiration and Olig1 acetylation.

Endogenous but not sensory-driven activity controls migration, morphogenesis and survival of adult-born neurons in the mouse olfactory bulb

Integrated transcriptome and proteomeanalysis in human brain organoids revealsposttranscriptional regulation of ribosomalgenes.

The paper integrates transcriptome and proteome data from human brain organoids to uncover posttranscriptional regulation of ribosomal genes during corticogenesis.

Choroid Plexus Modulates Subventricular Zone Adult Neurogenesis and Olfaction Through Secretion of Small Extracellular Vesicles

This study shows that choroid plexus-secreted small extracellular vesicles regulate adult neurogenesis in the subventricular zone and maintain olfaction.

Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization

The paper reveals topographic organization in a zebrafish vestibular brainstem circuit by showing birthdate correlates with neuronal position, innervation patterns, and connectivity.

Exploring the role of the outer subventricular zone during cortical folding through a physics-based model

This paper develops a physics-based model to explore how the outer subventricular zone influences cortical folding by integrating cellular processes with organ-scale mechanics.

Transgenerational effects of exercise on mouse brain and cognition

This study shows that exercise in mice can transmit cognitive benefits to the second generation through miRNA-mediated mechanisms, even when cellular changes in the first generation are lost.

Deficiency in neprilysin causes laminar impairments in the visual cortex

This study investigates the role of neprilysin in the development of the mouse visual cortex, finding laminar impairments and reduced inhibitory neurons in layer 4.

Integrative single-cell transcriptomics clarifies adult neurogenesis and macroglia evolution

The paper uses zebrafish single-cell transcriptomics to study macroglia evolution and adult neurogenesis, identifying conserved features and functional origins of astrocytes and radial glia-like cells.

Long-term cellular and molecular signatures of pregnancy in the adult and ageing brain

This study examines long-term effects of pregnancy on brain cellular and molecular changes in rats, finding increased synaptic proteins and altered aging trajectories.

Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells

The paper shows that immature dentate granule cells exhibit reduced transcriptional responses to spatial exploration compared to mature cells.

Dentate Neurogenesis Modulates Dorsal Hippocampal Excitation/Inhibition Balance Crucial for Cognitive Flexibility

This study shows that silencing newborn neurons in the dentate gyrus disrupts the excitation/inhibition balance in the dorsal hippocampus, impairing cognitive flexibility in mice.

Bulk and Mosaic Deletions of Egfr Reveal Regionally Defined Gliogenesis in the Developing Mouse Forebrain

This study investigates the role of EGFR in mouse forebrain development through bulk and mosaic deletions, revealing region-specific effects on glial lineage formation.

Neurogenin 2 and Neuronal Differentiation 1 control proper development of the chick trigeminal ganglion and its nerve branches

This study shows that Neurog2 and NeuroD1 are essential for proper development of the chick trigeminal ganglion and its nerve branches.

The differentiation and integration of the hippocampal dorsoventral axis are controlled by two nuclear receptor genes

This study identifies Nr2f1 and Nr2f2 as critical regulators of hippocampal dorsoventral axis differentiation and integration in mice.

Chronic Changes In Oligodendrocyte Sub-Populations After Middle Cerebral Artery Occlusion in Neonatal Mice.

This study uses scRNA-seq to analyze oligodendrocyte gene expression changes in a neonatal mouse model of stroke, identifying a reactive subset that may be a target for white matter repair.

Dephosphorylation of 4EBP1/2 Induces Prenatal Neural Stem Cell Quiescence

This study identifies the role of 4EBP1/2 dephosphorylation in inducing quiescence in embryonic neural stem cells, offering insights into adult brain development and potential therapeutic strategies.

Prdm16 and Vcam1 regulate the postnatal disappearance of embryonic radial glia and the ending of cortical neurogenesis

This study identifies Prdm16 and Vcam1 as regulators of postnatal radial glia disappearance and the termination of cortical neurogenesis.

Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase 1 promote oligodendrocyte development and myelination

ADAM10 mediates macroglial cell fate decisions in the developing brain

The paper shows ADAM10 regulates macroglial cell fate by promoting astrocyte generation and inhibiting oligodendrocyte production in developing brains.

Telomerase reverse transcriptase (TERT)-expressing cells mark a novel stem cell population in the adult mouse brain

This study identifies TERT-expressing cells as a novel multipotent stem cell population in the adult mouse brain, capable of differentiating into multiple cell types.