Neurogenesis and neuroplasticity mechanisms

Activation of Shh/Smo is sufficient to maintain oligodendrocyte precursor cells in an undifferentiated state but is not necessary for differentiation

This study shows that Shh/Smo activation maintains oligodendrocyte precursor cells (OPCs) in an undifferentiated state but is not required for myelination or remyelination.

Serine Racemase mediates Subventricular Zone Neurogenesis via Fatty acid Metabolism.

This study shows that serine racemase (SR) influences adult subventricular zone (SVZ) neurogenesis by regulating fatty acid synthesis and lipid metabolism.

Direct and indirect neurogenesis generate a mosaic of distinct glutamatergic projection neuron types in cerebral cortex

The paper uses genetic fate mapping in mice to show how direct and indirect neurogenesis contribute differently to the diversity and connectivity of glutamatergic projection neurons in the cerebral cortex.

Neuronal lineage tracing from progenitors in human cortical organoids reveals novel mechanisms of human neuronal production, diversity, and disease

The paper uses lineage tracing in human cortical organoids to show that most neurons arise from intermediate progenitors and that genetic variants affect lineage-specific transcriptional profiles and neuron diversity.

Persistence of FoxJ1+ Pax6+ Sox2+ ependymal cells throughout life in the human spinal cord

The paper shows that FoxJ1+ Pax6+ Sox2+ ependymal cells persist in the human spinal cord throughout life, maintaining neurodevelopmental gene expression and structural features similar to those in mice and young humans.

The temporal balance between self-renewal and differentiation of human neural stem cells requires the Amyloid Precursor Protein

This study shows that Amyloid Precursor Protein (APP) is required for human neural stem cells to maintain a progenitor state during prolonged neurogenesis, unlike mouse NSCs where APP is dispensable.

Repurposing of the multiciliation gene regulatory network in fate specification of Cajal-Retzius neurons

The paper identifies a gene regulatory network involved in multiciliation that is repurposed in the fate specification of Cajal-Retzius neurons, leading to distinct cellular outcomes.

Astrocyte-Oligodendrocyte interaction regulates central nervous system regeneration

The paper shows that astrocyte-oligodendrocyte interaction is critical for remyelination and identifies a drug strategy targeting this interaction to promote central nervous system regeneration.

The Neonatal Gyrencephalic Cortex Maintains Regionally Distinct Streams of Neuroblasts

The paper identifies an expanded subventricular zone in neonatal gyrencephalic brains that supports ongoing neuronal migration to the cortex.

Ubiquitous lognormal distribution of neuron densities in mammalian cerebral cortex

The paper shows neuron densities in mammalian cerebral cortex follow a lognormal distribution across and within cortical areas, suggesting a new organizational principle.

After traumatic brain injury oligodendrocytes regain a plastic phenotype and can become astrocytes

This study shows that oligodendrocytes can convert into astrocytes after traumatic brain injury through a transitional AO cell stage, influenced by local environmental cues.

Deterministic and probabilistic fate decisions co-exist in a single retinal lineage

The paper uses live imaging to show that retinal progenitors make both deterministic and probabilistic fate decisions, with stochasticity increasing under developmental stress.

Development of Synthetic Modulator Enabling Long-Term Propagation and Neurogenesis of Human-Derived Neural Progenitor Cells

This study develops a DNA-based modulator to replace growth factors in culturing human neural progenitor cells, enabling long-term propagation and neurogenesis.

Rescue of neurogenesis and age-associated cognitive decline in SAMP8 mouse: role of transforming growth factor alpha

This study shows that targeting TGF-alpha release rescues neurogenesis and cognitive decline in SAMP8 mice, suggesting it as a potential therapeutic strategy for age-related neurological disorders.

Notch directs telencephalic development and neuron fate determination by regulating miRNA levels

This study shows Notch signaling regulates miRNA levels to control neuron fate determination and telencephalic development.

Pgbd5 impacts neuronal differentiation and double strand breaks signaling in the developing cortex

This study shows Pgbd5 is essential for neuronal differentiation and radial migration in mouse corticogenesis, with effects on DNA double-strand breaks and gene expression.

The exon junction complex component EIF4A3 is essential for mouse and human cortical progenitor mitosis and neurogenesis

This study shows EIF4A3 controls mitosis duration and cell survival in mouse and human neural progenitors, linking it to neurodevelopmental disorders.

Phosphorylation of 53BP1 by ATM enforce neurodevelopmental programs in cortical organoids

This study shows that ATM-mediated phosphorylation of 53BP1-serine 25 is essential for neural progenitor cell proliferation and neuronal differentiation in cortical organoids.

Autophagy is a cell-intrinsic driver of neural stem cell quiescence in hippocampal dentate gyrus development

This study shows autophagy is essential for establishing quiescence in hippocampal neural stem cells during development.

Diversity within olfactory sensory derivatives revealed by the contribution of Dbx1 lineages

The paper shows Dbx1-expressing progenitors in the olfactory epithelium contribute to multiple neuronal lineages, revealing unexpected diversity in their neurogenic potential.

Modeling the marmoset brain using embryonic stem cell-derived cerebral assembloids

This paper develops an in vitro marmoset brain model using cerebral assembloids to study neural development and activity.

Enhanced endogenous activity predicts elimination of adult-born neurons in the mouse olfactory bulb

The paper identifies enhanced endogenous Ca2+ signaling as a predictor of elimination in adult-born neurons in the mouse olfactory bulb.

Homeostatic Regulation of Seizure Susceptibility and Cognitive Function by Derlin-1 through Maintenance of Adult Neurogenesis

This study shows that Derlin-1 maintains adult neurogenesis by regulating Stat5b, thereby affecting seizure susceptibility and cognitive function in mice.

Biallelic null variants in PNPLA8 cause microcephaly through the reduced abundance of basal radial glia

This study identifies biallelic PNPLA8 variants causing microcephaly by reducing basal radial glia in cerebral organoids and disrupting phospholipid metabolism.

Loss of LRP1 in adult neural stem cells impairs migration to ischemic lesions

This study shows that loss of LRP1 in adult neural stem cells impairs their migration to ischemic lesions both in vivo and in vitro.

Immature neurons in the primate amygdala: changes with early development and disrupted early environment

The paper examines immature neuron development in primate amygdala, finding maturation and reduced neuron counts with age, and no effect of maternal separation on immature neuron counts but a correlation with mature neuron counts.

Early myelination involves the dynamic and repetitive ensheathment of axons which resolves through a low and consistent stabilization rate

The paper quantifies axon ensheathment dynamics in zebrafish oligodendrocytes, finding a high and consistent sheath destabilization rate despite variable initiation.

Microcephaly-associated WDR62 mutations hamper Golgi apparatus-to-spindle pole shuttling in human neural progenitors

This study shows that WDR62 mutations disrupt Golgi-to-spindle pole shuttling in neural progenitors, leading to neurodevelopmental abnormalities in microcephaly.

RGS6 mediates exercise-induced recovery of hippocampal neurogenesis, learning, and memory in an Alzheimer's mouse model

This paper shows that RGS6 in hippocampal neural progenitors mediates exercise-induced recovery of neurogenesis and cognition in Alzheimer's mice.

Low forces push the maturation of neural precursors into neurons

The paper shows that mechanical stimulation via magnetic nano-pulling accelerates neural precursor maturation into neurons and alters neuronal network organization.