Telomeres, Telomerase, and Senescence

Senescent cells are more susceptible to reductive stress-induced cell death: implications for senolytic research.

The paper shows human senescent myoblasts are more susceptible to reductive stress-induced cell death than proliferating cells, suggesting senolytic compounds may work via reductive stress.

Constitutive macropinocytosis sustains the inflammatory phenotype of senescent cells

This study identifies macropinocytosis as a key driver of the senescence-associated secretory phenotype (SASP) through PAK1 and TGFβ signaling in senescent cells.

Acetylation-dependent remodeling of the secretory pathway shapes the senescence-associated secretome

This study identifies acetylation-dependent remodeling of the secretory pathway in senescence, showing its role in shaping the senescence-associated secretome.

Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1

This study investigates how telomeres impede replication by showing G-rich DNA and shelterin subunit POT1 block lagging strand replication, with POT1 causing Okazaki fragment skipping and large single-stranded gaps.

Inherited long telomeres induce a genome-wide transcriptional response in budding yeast

This study shows that inherited long telomeres in budding yeast cause a genome-wide transcriptional response, affecting gene expression across the genome.

Multiscale Analysis of Cellular Senescence through Ripley's Functions and Functional Statistics.

This paper develops a multiscale framework to analyze the spatial organization of senescent cells in post-infarction mouse hearts using statistical and functional methods.

Matrix stiffness induces endothelial network senescence

This study shows matrix stiffness induces endothelial cell senescence through a Notch-JNK-FOS pathway, supported by in vitro models and patient tissue analysis.

Senescence targeting re-enables injury-responsive repair in a human RPE aging model

This study uses a human RPE aging model to show that targeting senescent cells can re-enable injury-responsive repair in aged RPE.

Bidirectional modulation of aging-associated cellular phenotypes by mitochondrial genome replacement

This study shows mitochondrial genome replacement can reverse or accelerate aging-related cellular decline in fibroblasts and T cells from mice and humans.

Differential Enhancer Activity and FOXF1 Levels Contribute to Higher Inflammatory Gene Expression of Fetal/Neonatal Versus Adult Fibroblasts in IR-induced Senescence

The paper shows that fetal/neonatal fibroblasts show higher inflammatory gene expression than adult fibroblasts in IR-induced senescence due to differences in enhancer activity and FOXF1 levels.

miR-425-5p Regulates Cellular Senescence Through Modulation of Retinoblastoma Protein Phosphorylation

This study identifies miR-425 as a regulator of cellular senescence through modulation of RB phosphorylation and PPP2CB expression, with implications for therapeutic interventions.

Decoding and Targeting Coordinated CDKN1A and CDKN2A Senescence Programs in ECM-Dominant Cardiovascular Pathologies

This study identifies ECM-dominant cardiovascular diseases as driven by coordinated CDKN1A and CDKN2A senescence programs in fibroblasts and shows senolytic treatments improve cardiac function.

Replicative senescence of neural progenitors induces astrocyte senescence in 2D cultures and human midbrain organoids

This study uses human iPSC-derived cells to model replicative senescence in neural progenitors and shows it induces astrocyte senescence in 2D cultures and midbrain organoids, linking it to Parkinson's disease.

Uncovering senescent fibroblast heterogeneity connects DNA damage response to idiopathic pulmonary fibrosis

The paper identifies senescent fibroblast heterogeneity in IPF and links it to DNA damage response dysregulation using gene expression analysis.

The Translatome of Senescent Cells Revealed by Sequencing Actively Translated mRNA

This study uses AHARIBO to profile the translatome of human fibroblasts, revealing post-transcriptional regulation of senescence programs and identifying L1HS elements involved in inflammatory cDNA production.

TERT drives liver tumorigenesis beyond telomere elongation

This study shows TERT promotes liver tumors independently of telomere elongation, revealing molecular and metabolic features relevant to immunotherapy response.

Telomere Length as an Indicator of Lifestyle-Related Biological Aging in Hypertensive Adults: A Pilot Exploratory Study

This study examines the relationship between lifestyle factors and telomere length in hypertensive adults, finding higher telomere ratios in hypertensive individuals compared to controls.

SenCat: Cataloging human cell senescence through multiomic profiling of multiple senescent primary cell types

SenCat catalogs senescence markers across 14 human cell types using transcriptomic and proteomic profiling, revealing shared metabolic pathways and enabling machine learning-based identification of senescent cells.

Distinct fibroblast and perivascular senotypes define spatial niches that regulate fibrosis

The paper identifies distinct fibroblast and perivascular senescence subtypes in fibrosis using single-cell and spatial transcriptomics, showing their spatial organization and roles in fibrosis progression.

Alternative Lengthening of Telomeres and CINSARC are interconnected toward non-translocation-related sarcomas progression

The paper investigates the relationship between alternative lengthening of telomeres (ALT) and the CINSARC signature in non-translocation-related sarcomas, showing their strong association.

A tumour-host feed-forward loop contributes to malignant growth in chromosomal instability-induced epithelial tumours

The paper shows that aneuploidy-induced senescent cells in Drosophila tumours secrete proteins that promote non-autonomous cell death, which in turn enhances tumour growth through feedback mechanisms.

Saturating variant analysis of TERC redefines the human telomerase reverse transcription mechanism

The paper functionally analyzes TERC variants to redefine the human telomerase reverse transcription mechanism, revealing eight templating residues and a hyperactive variant that lengthens telomeres.

Senescent myoblasts exhibit ROS-dependent Akt-mTORC1 dysregulation and are susceptible to reductive stress-induced cell death.

This study identifies ROS-dependent Akt-mTORC1 dysregulation in senescent myoblasts and shows antioxidants can suppress inflammation and promote differentiation but also induce cell death.

The Ets family transcription factor EHF suppresses senescence-associated inflammatory responses

This study identifies EHF as a negative regulator of senescence-associated secretory phenotype (SASP) by linking it to the p38/NF-κB/IκBζ inflammatory pathway.

An Open Competition for Biomarkers of Aging

The paper presents results from an open competition to develop aging biomarkers using DNA methylation data, showing improved predictive models for age, mortality, and multi-morbidity.

Shaving black fur uncovers hidden issues in p16-3MR mice

The paper identifies issues with the p16-3MR mouse model for in vivo bioluminescence imaging, showing that fur shaving is necessary for accurate signal detection and that previous results may be unreliable.

Tabular foundation model predicts alternative lengthening of telomeres (ALT) and identifies SMARCAL1 as a target in ALT-driven cancers

The paper develops ALTitude, a machine learning model to predict ALT status from whole genome sequencing data, identifies SMARCAL1 as a therapeutic target in ALT-driven cancers.

Early-life telomere length variation under changing developmental conditions in long-lived bats

The paper examines how early-life environmental conditions and maternal age affect telomere length in two bat species and finds no link between early telomere length and short-term survival.

Mapping the genomic and transcriptomic features associated with telomere maintenance mechanisms in complex karyotype sarcomas

The paper identifies genomic and transcriptomic features of telomere maintenance mechanisms in complex karyotype sarcomas, linking ALT status to therapeutic vulnerabilities.

Telomere maintaining germline and somatic variants in thyroid cancer and melanoma

The paper examines the mutual exclusivity and clinical associations of germline long-telomere syndrome variants and somatic TERT promoter mutations in thyroid cancer and melanoma, finding they are mutually exclusive but have distinct clinical impacts.