Dietary Effects on Health

Tumbly: An Open-Source Home-Cage Device for Time-Restricted Feeding in Mice

Tumbly is an open-source, automated device for time-restricted feeding in mice, validated to maintain body weight and food intake with low error rates.

Integrated Multiomics Reveals Intergenerational Brain Sensory System Remodeling Induced by Parental Intermittent Fasting

This study shows that parental intermittent fasting induces intergenerational molecular changes in the brain, affecting sensory pathways and sex-dependent gene expression in offspring.

The Neural Protective Effects of Intermittent Fasting in Adult Drosophila Following Traumatic Brain Injury Exposure.

This study shows that intermittent fasting improves survival and behavior in Drosophila after traumatic brain injury and reduces inflammation in neural tissues.

Time restricted feeding ameliorates colitis through clock-dependent and nutrition-dependent processes

This study shows that a 12-hour time-restricted feeding regimen reduces colitis in mice through both clock-dependent and nutrition-dependent mechanisms.

Time-restricted eating promotes sustained fat loss in Drosophila

This study shows that time-restricted eating in Drosophila leads to sustained fat loss and improved muscle function without calorie restriction.

Neuronal ketone body utilization couples exercise and time-restricted feeding to cognitive enhancement

This study investigates the role of neuronal and hepatic ketone metabolism in cognitive enhancement from exercise and time-restricted feeding in mice, finding neuronal utilization is essential while hepatic production is contributory.

Caloric restriction and intermittent fasting during lactation are linked to impaired maternal care, increased impulsivity and amygdala redox imbalance in dams

This study shows that caloric restriction and intermittent fasting during lactation in rats impair maternal care, increase impulsivity, and cause amygdala redox imbalance.

Fasting-mimicking diet counteracts gut microbial dysbiosis in experimental Lynch syndrome

This study shows that fasting-mimicking diets reduce gut microbial dysbiosis in Lynch syndrome mouse models, preserving beneficial bacteria and altering metabolic pathways linked to cancer progression.

Effects of long-term fasting: longitudinal epigenetic responses in humans

This study examines the epigenetic effects of prolonged fasting in humans, finding changes in DNA methylation and epigenetic aging clocks linked to metabolic responses.

Time-Restricted Feeding Extends Healthspan in Both Sexes and Lifespan in Male C57BL/6J Mice

This study shows that time-restricted feeding extends healthspan in both sexes and lifespan in male mice under normal dietary conditions.

Time-restricted feeding corrects aggravation of glucose intolerance and circadian disruption induced by weight cycling in obese young mice

This study shows that time-restricted feeding improves glucose intolerance and circadian disruption caused by weight cycling in young obese mice, but not in mid-aged mice.

Fasting disrupts the InsP6 HDAC3 axis to drive ER stress-mediated clearance of DNA-damaged cells and enforce tissue quality control.

The paper shows that fasting disrupts the TGF-β-InsP6-HDAC3 axis, inducing ER stress and eliminating DNA-damaged cells to maintain tissue quality.

Uncovering Shared and Tissue-Specific Molecular Adaptations to Intermittent Fasting in Liver, Brain, and Muscle

This study identifies tissue-specific and shared molecular adaptations to intermittent fasting in liver, brain, and muscle using proteomics and transcriptomics.

Anticipatory metabolic reprogramming distinguishes caloric restriction from fasting-refeeding cycles

This study compares caloric restriction (CR) and fasting-refeeding (FRF) in mice, finding that CR uses anticipatory metabolic control while FRF relies on direct nutrient cues.

Ketogenesis is dispensable for the metabolic adaptations to caloric restriction

This study shows that ketogenesis is not essential for the metabolic benefits of caloric restriction in mice, as Hmgcs2 deletion does not impair key metabolic adaptations.

Sex- and ketogenesis-dependent effects of intermittent fasting against diet-induced obesity and fatty liver disease

This study shows that intermittent fasting improves systemic metabolism regardless of ketogenesis but has sex-specific hepatic benefits requiring ketogenesis in mice.

Time-restricted feeding attenuates allergic dermatitis in mice and is associated with modulation of leptin-driven inflammatory pathways

This study shows that time-restricted feeding reduces allergic dermatitis in mice by modulating leptin-driven inflammatory pathways.

Limited microglial metabolic improvement with time-restricted feeding in diet-induced obesity

This study examines how time-restricted feeding affects microglial immunometabolism in obese rats, finding that TRF during the active phase reduces fat mass and alters microglial transcriptome rhythmicity, but does not reverse HFD-induced metabolic inflexibility.

Time-restricted feeding leads to sex- and organ-specific responses in the murine digestive system

This study examines sex- and organ-specific responses to time-restricted feeding in mice, showing differential effects on weight gain, glucose levels, and gene expression across tissues.

Time-Restricted Feeding Attenuates Kidney Damage and Preserves Renal Function in Mouse Model of Chronic Kidney Disease

Systemic multi-omic remodelling underlies health benefits of intermittent fasting

This study examines the systemic effects of intermittent fasting in humans over six months, revealing changes in iron metabolism, immune markers, and microbiota, with implications for aging and health.

In vitro efficacy of Fasting Mimicking Conditions combined with targeting of starvation escape pathways against prostate cancer cells

This study shows that fasting mimicking conditions combined with targeted therapies enhance the efficacy of prostate cancer treatments by exploiting metabolic vulnerabilities.

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer&aposs disease

This study shows that fasting, not just calorie reduction, is necessary for many benefits of caloric restriction in 3xTg mice with Alzheimer's disease.

Insulin Prevents Fat Loss and Promotes Muscle Loss During Intermittent Fasting in Obesity

This study shows that high insulin levels in obesity reduce fat loss and increase muscle loss during intermittent fasting.

Unraveling cysteine deficiency-associated rapid weight loss

This study shows that cysteine restriction in mice causes rapid weight loss by depleting glutathione and coenzyme A, activating stress responses, and increasing lipolysis.

Succinate Modulation as a Novel Mechanism Underlying the Effects of Intermittent Fasting on Brain Function and Metabolism in Diet-Induced Obesity

Pre-exposure to time-restricted feeding reduces tissue CD4+ T cells with a limited effect on Mycobacterium tuberculosis clearance at the early time point

This study shows that time-restricted feeding improves metabolic health in mice but has limited effect on reducing Mycobacterium tuberculosis burden early after infection.

Ability to predict irregular periods of food deprivation improves body-weight regulation and reduces weight gain in food-insecure starlings

This study shows that predictable food deprivation in starlings reduces weight gain and improves body-weight regulation compared to unpredictable deprivation.

Time restricted feeding with or without ketosis influences metabolism-related gene expression in a tissue-specific manner in aged rats

This study examines how different diets affect metabolism-related gene expression in aged rats' tissues and links these changes to cognitive performance.

Feeding-fasting cycle of obesogenic food determines glucocorticoid neuromodulation of cortico-hippocampal activities sustaining long-term memory

This study shows that adjusting meal timing can reverse memory impairments and glucocorticoid signaling imbalances caused by constant access to high-calorie food in mice.