biophysical modeling

Geometric confinement regulates ERK signaling dynamics and collective migration

This study shows that geometric confinement affects ERK signaling and collective migration in epithelial tissues by altering mechanical states through actomyosin contractility.

Assembly principles of a SYCP2-HORMAD1-HORMAD2 mammalian meiotic axis complex

This study identifies a new closure motif in SYCP2 and shows how HORMAD1 and HORMAD2 form a heterodimer, revising the model of mammalian meiotic axis assembly.

Inference of enhancer-specific transcription factor interactions from gene expression data using a biophysical model

The paper infers enhancer-specific transcription factor interactions from gene expression data using a biophysical model and validates it with simulated and experimental data.

Shared biosynthetic architectures generate diverse β-amino polyketide residues in cyanobacterial peptides

The paper links gene clusters in Floridanema to the production of β-amino polyketide residues, revealing shared biosynthetic architectures and evolutionary strategies.

TPR Domains Drive the Functional Phase Separation of HOP and its Regulation by Hsp90 and Hsp70

This study shows HOP forms stress-induced biomolecular condensates via phase separation driven by TPR domains, regulated by Hsp70 and Hsp90, and its dysfunction increases misfolding stress.

Inositol Pyrophosphates Mediate Chloroplast Lipid Remodeling and Nuclear Gene Repression during High-Light Acclimation in Chlamydomonas reinhardtii

Flightless I and LRRFIP work together to regulate lateral growth of the sarcomeres in Drosophila

This study identifies Flightless I and LRRFIP as regulators of lateral sarcomere growth in Drosophila flight muscle through actin filament integration at the Z-disc.

Selective inhibition of respiratory complex I reveals a bioenergetic vulnerability in Francisella

This study identifies respiratory complex I as a selective vulnerability in Francisella and shows that tolfenpyrad inhibits it with species-specific antibacterial activity.

Supraphysiological Estradiol During Ovarian Stimulation Reveals Microbiome Resilience and Prevotella Opportunism

The paper examines how the oral microbiome responds to high estradiol levels during ovarian stimulation, finding saliva tracks systemic hormone changes and Prevotella species exploit hormonal surges.

Enhanced strand transfer and mismatch extension by HIV-1C reverse transcriptase promote sequence motif duplication

This study identifies subtype-specific biochemical properties of HIV-1C reverse transcriptase that enhance sequence motif duplication through improved strand transfer and mismatch extension.

RNA G-Quadruplexes Function as a Tunable Switch of FUS Phase Separation

This study identifies RNA G-quadruplexes as tunable regulators of FUS phase separation, showing they can inhibit or nucleate aggregation depending on structure and concentration.

DNA remodeling couples target recognition to directional transposition in a Tn7-like CAST

This study defines the assembly pathway of a Tn7-like CAST, showing how DNA remodeling and TnsC positioning convert target recognition into directional transposition.

Intramolecular interactions between folded and disordered regions shape ubiquilin structure and function

The paper investigates how intramolecular interactions between folded and disordered regions of ubiquilin proteins influence their structure and function across different species.

Quantitative biophysical analysis of human septin hexamer and octamer self-assembly on model membranes

This study quantitatively compares the membrane binding and self-assembly of human septin hexamers and octamers using biophysical methods, revealing distinct structural properties and functional implications.

Heterologous iron-sulfur cluster biogenesis and delivery for cytosolic isobutanol and isopentanol production in Saccharomyces cerevisiae

This study enhances cytosolic isobutanol and isopentanol production in yeast by introducing prokaryotic iron-sulfur cluster biosynthesis genes and accessory proteins.

The R2T(P) complex orchestrates the SHQ1 driven early steps of box H/ACA snoRNP maturation

This paper identifies a novel role for the R2T complex in early box H/ACA snoRNP maturation by characterizing interactions between SHQ1, RuvBL1:RuvBL2, and other factors.

MEMBRANE PORES ACT AS SELF-RESEALING LIPID SCRAMBLASES

The paper shows that lipid asymmetry drives pore formation in membranes, which function as self-resealing scramblases to restore balance.

BRCA1 promotes homologous recombination through separable DNA and RAD51 binding activities within its disordered region.

This study identifies DNA binding and RAD51 interaction interfaces in BRCA1's disordered region and shows their distinct roles in homologous recombination and DNA repair.

Rapid vaccine induction of macaque HIV-1 V2 Apex broadly neutralizing antibodies with immunogenetic signatures that are potentially translatable to humans

This study shows that vaccination of macaques with an Env-ferritin nanoparticle rapidly elicits V2-apex broadly neutralizing antibodies with immunogenetic features that may be applicable to humans.

FlcE latches onto the FliL-stator complex to turbocharge flagellar motility in Borrelia burgdorferi

This paper identifies FlcE as a flagellar collar protein in Borrelia burgdorferi that stabilizes the FliL-stator complex, enhancing motility and torque generation.

The GNMT N-terminus Couples Folate Feedback to Methyl-donor Homeostasis

This study identifies the GNMT N-terminal tail and its phosphorylation at S9 as a regulatory mechanism linking folate feedback to SAM homeostasis.

Canonical G-protein coupled receptors of vascular plants

The paper identifies GCR1 as the sole GPCR in vascular plants through phylogenetic and bioinformatic analysis, suggesting its role in root hair function.

Phage RyR-domain proteins degrade ADPR-based immune signals and fuel NAD synthesis

This study identifies RyDEP as an enzyme that degrades 2'cADPR and 3'cADPR immune signals, inactivating bacterial defense and restoring NAD+.

An NO-binding Cache domain receptor interacts with a Ser/Thr kinase through a conserved HAMP domain interaction

The paper identifies a bacterial NO-binding Cache_heme-HAMP receptor that interacts with a Ser/Thr kinase via conserved motifs, revealing a novel mechanism of NO signaling.

NANOG assembles into self-limiting aging micelles that drive a sol-gel transition and modulate DNA dynamics

This study investigates NANOG's rheological properties, showing it forms self-limiting micelles that modulate DNA dynamics and may regulate gene expression through gel-like environments.

Ultra-slow conformational dynamics and catch bond formation of a Bacterial Adhesin revealed by a single-domain variant of FimH.

This study investigates FimH conformational dynamics and catch bond formation using a single-domain variant, revealing ultra-slow dynamics and a dynamic allosteric mechanism.

A single mycobacterial ligand organizes multi-receptor signaling to reprogram macrophage lipid metabolism

This paper shows that the mycobacterial ligand ManLAM uses structural features to engage TLR2 and Dectin-2, reprogramming macrophage lipid metabolism and promoting foam cell formation.

Opposing regulation by Rev1 of DNA polymerase zeta activity on damaged versus undamaged DNA

This study shows Rev1 inhibits Pol zeta activity on undamaged DNA but stimulates it at damaged sites, with the N-terminal M1 motif mediating this regulation.

Endogenous RALF peptide function is required for powdery mildew host colonization

This study shows that endogenous RALF peptides, perceived by FER and LLG-LRX complexes, are required for powdery mildew colonization of Arabidopsis, with RALF function influencing cell wall remodeling and apoplastic pH.

Design principles of a membrane-spanning ubiquitin ligase

The paper describes the structure and function of a membrane-spanning E3 ubiquitin ligase complex, revealing its role in developmental processes and linking mutations to human birth defects.