Cell death mechanisms and regulation

C. elegans E3 ubiquitin ligase EBAX-1 promotes non-apoptotic linker cell-type death through target-directed miRNA degradation

A kinome inhibitor screen implicates adhesion and growth factor signaling in cellular recovery after caspase activation

This study identifies kinases involved in cellular recovery after caspase activation using a kinome inhibitor screen, revealing roles for adhesion, cytoskeleton, and growth factor signaling.

De novo Cyclic Peptides Allow Visualisation of the Monomeric and Functional Amyloid Conformations of the Kinase RIPK3

The paper identifies cyclic peptides that bind RIPK3's RHIM-containing region, enabling visualization of its monomeric and functional amyloid conformations in live cells.

Characterization of the direct and indirect inhibition ofapoptosis by full-length recombinant Bcl-xL monomers

This study characterizes how full-length recombinant Bcl-xL monomers inhibit apoptosis through direct and indirect mechanisms using in vitro and organelle assays.

Zbtb38 transcriptionally activates XIAP to regulate apoptosis in development and cancer

This study identifies Zbtb38 as a transcriptional activator of XIAP, showing its role in regulating apoptosis during development and cancer, with implications for therapeutic targeting.

A high-resolution dimeric structure reveals a critical role of alpha-helix 9 in apoptotic Bax pore assembly in the mitochondrial membrane

This paper presents a high-resolution NMR structure of Bax helix 9, showing its role in dimerization and pore formation during apoptosis, supported by mutagenesis and simulations.

Drug tolerant persisters and immunotherapy persister cells exhibit cross-resistance and share common survival mechanisms

This study identifies common survival mechanisms between drug-tolerant persisters and immunotherapy persisters, showing they share reduced mitochondrial apoptotic sensitivity and cross-resistance to therapies.

Stochasticity contributes to explaining minority and majority MOMP during apoptosis

This study shows stochasticity in protein distributions and interactions contributes to heterogeneity in mitochondrial MOMP during apoptosis, affecting both minority and majority MOMP scenarios.

The Homeodomain-interacting protein kinase Hipk promotes apoptosis by stabilizing the active form of Dronc

This study identifies Hipk as a regulator of Dronc stability and apoptotic signaling in Drosophila, revealing a feedback loop between Hipk and Dronc.

Modification of Death receptor-mediated cell death in osteosarcoma cell lines using epigenetic modifiers

This study evaluates the combination of epigenetic modifiers with an anti-DR5 agonistic mAb to enhance anti-cancer efficacy in osteosarcoma cell lines.

Non-apoptotic death of the C. elegans linker cell is primed by MYRF-1 activation of pqn-41/polyQ

The paper identifies MYRF-1 as a regulator of non-apoptotic linker cell death in C. elegans, showing its role in priming death through activation of pqn-41/polyQ.

Bcl-xL interaction with VDAC1 reduces mitochondrial Ca2+ uptake, allowing the establishment of Therapy-Induced Senescence.

This study identifies Bcl-xL-VDAC1 interaction as a mechanism that reduces mitochondrial Ca2+ uptake, promoting therapy-induced senescence by preventing apoptosis.

The Initiator Caspase Dronc Drives Compensatory Proliferation of Apoptosis-Resistant Cells During Epithelial Tissue Regeneration After Ionizing Radiation

This study identifies Dronc-driven compensatory proliferation in Drosophila wing imaginal discs after ionizing radiation, revealing molecular mechanisms and interactions that maintain tissue regeneration balance.

EOR-1/PLZF-regulated WAH-1/AIF sequentially promotes early and late stages of non-apoptotic corpse removal

This study identifies EOR-1/PLZF as a regulator of WAH-1/AIF, which sequentially promotes non-apoptotic corpse removal during development.

A clinical-stage oncology compound selectively targets drug-resistant cancers

This study reveals that PAC-1, a clinical-stage oncology compound, targets drug-resistant cancers by disrupting iron homeostasis and exploiting MDR1 expression to induce iron depletion.

Ferrapoptosis: Discovery of a Hybrid Programmed Cell Death

This paper defines and validates a new form of cell death called Ferrapoptosis, which combines features of ferroptosis and apoptosis in traumatic brain injury, and identifies Smg7 as a key regulator.

Dynamical analysis of a model of BCL-2-dependent cellular decision making

This study uses mathematical modeling to show that BCL-2 network architecture enables tristability in cell-fate decisions, with stochastic fluctuations driving heterogeneous outcomes.

Allosteric regulation of BH3-in-groove interactions by tail anchors of BCL-xL complexes limits BH3 mimetic antagonism.

The paper shows that tail anchors of BCL-xL and PUMA modulate BH3-in-groove interactions, affecting BH3 mimetic antagonism and cell survival.

Challenging a role for ceramide channels and microdomains in apoptosis induction using a bottom-up approach

This study challenges models of ceramide-induced apoptosis by showing ceramides cannot form channels or substitute for cardiolipin in Bax pore formation.

Endothelial RIPK3 minimizes organotypic inflammation and vascular permeability in ischemia-reperfusion injury

This study shows that endothelial RIPK3 reduces vascular permeability and inflammation in ischemia-reperfusion injury by regulating IL-6 secretion and adhesion molecule expression.

Structural basis of apoptosis induction by the mitochondrial voltage dependent anion channel

This study reveals how VDAC1 oligomerization triggers apoptosis by exposing its N-terminal helix, which neutralizes anti-apoptotic BclxL and promotes pore formation by Bak.

Large transient assemblies of Apaf1 constitute the apoptosome in cells

The paper shows that Apaf1 forms transient foci during apoptosis, which correspond to the apoptosome and regulate apoptosis progression.

GDF15 regulates necroptotic cell death through direct interaction with RIPK3

The paper identifies GDF15 as a negative regulator of necroptotic cell death by directly interacting with RIPK3, enhancing necroptosis in tumor cells.

Extrinsic Apoptosis and Necroptosis in Telencephalic Development: A Single-Cell Mass Cytometry Study

This study uses single-cell mass cytometry to show that deleting RIPK3 and Caspase-8 increases cell count in the mouse telencephalon, indicating non-exclusive roles for extrinsic apoptosis and necroptosis in developmental cell elimination.

Bergeyella cardium variant induces unique cytoplasmic vacuolization cell death

This study identifies Bergeyella cardium variant-induced cytoplasmic vacuolization cell death and shows SLC9A9 and OMVs play key roles in this process.

A New anticancer substance from cancer cell apoptosis. CSS (Cancer cell Suicide Substance) production in culture.

This study identifies a unique low molecular weight substance (CSS) produced by cancer cells that exerts cytocidal effects on other cancer cells and extends lifespan in mice.

C. elegans CED-3 caspase promotes non-apoptotic linker cell dismantling but not death onset

The paper shows that CED-3 caspase in C. elegans promotes non-apoptotic linker cell dismantling but not death onset, and reveals similar mechanisms in mouse cells.

Quiescent OXPHOS-high triple-negative breast cancer cells that persist after chemotherapy depend on BCL-XL for survival

This study identifies OXPHOS-high quiescent triple-negative breast cancer cells that survive chemotherapy and depend on BCL-XL for survival, showing that targeting BCL-XL enhances chemotherapy efficacy.

Atypical contribution of caspase-3 to melanoma cancer cell motility by regulation of coronin 1B activity

This study identifies a non-apoptotic role for caspase-3 in melanoma cell motility by regulating coronin 1B activity, suggesting it as a potential target for anti-metastatic therapies.

The regulatory effect of Ca2+/calmodulin dependent protein kinase II mediated by receptor interacting protein kinase 3 on necroptosis of hypertrophic cardiomyocytes

This study investigates how RIPK3 regulates necroptosis and CaMKII activity in hypertrophic cardiomyocytes, showing that inhibiting RIPK3 alleviates myocardial hypertrophy and oxidative stress.