Cell death mechanisms and regulation

The MIRO1-BAX Complex Dictates Life and Death at the Mitochondrial Gate

This study identifies MIRO1 as a context-specific modulator of BAX activity, showing it drives distinct cell death pathways in glioma cells and Parkinsonian neurons through different mechanisms.

Species-Specific Roles of RIPK1 and TRADD in TNF-Induced Cell Death Reveal a Translational Gap Between Mouse Models and Human Biology

This study identifies species-specific differences in TNF-induced cell death mechanisms between human and mouse cells, highlighting discrepancies in RIPK1 and TRADD function that affect drug efficacy.

Endophilin B1 primes mitochondria for execution

This study identifies endophilin B1 as a membrane remodeling protein that primes mitochondria for Bax-mediated permeabilization during apoptosis.

Dynamic regulation of the Bcl-xL-BAD interaction

This study uses FLIM-FRET to show that apoptotic stress increases Bcl-xL-BAD interaction, with structural mutants revealing distinct binding requirements and functional outcomes.

Mechanistic Insights into MLKL Activation via Allosteric Pathways Identified Through Molecular Models

The paper uses molecular models to study MLKL activation mechanisms, identifying conformational changes and allosteric pathways critical for necroptosis.

Targeting primary and metastatic ovarian cancer with a peptide derived from the human NAF-1/CISD2 protein

This paper demonstrates that a peptide derived from CISD2/NAF-1 selectively targets and destroys ovarian cancer mitochondria, reducing tumor size and growth in vivo.

Inhibition of IAPs induces programmed cell death and inflammatory signaling in patient-derived metastatic breast cancer organoids

This study shows that Smac mimetics induce apoptosis in breast cancer organoids and that necroptosis, associated with inflammation, can be inhibited by LUBAC inhibitors.

ATF2 phosphorylation is a core transcriptional driver of neuron apoptosis

The paper identifies ATF2 phosphorylation as a key driver of neuron apoptosis and shows that inhibiting ATF2 protects neurons in culture and in vivo.

Molecular determinants of Bcl-xL membrane insertion - Structural plasticity exploration in solution and in nanodiscs identifies IsoAsp deamidation as a loss-of function mechanism in vivo.

Hepatocyte-like cells die via steroid hormone and nuclear receptor E75-mediated apoptosis

The paper shows that larval oenocytes in Drosophila die by apoptosis regulated by ecdysone and E75, revealing how systemic hormones control cell death in metabolic organs.

Structural and dynamic basis of indirect apoptosis inhibition by Bcl-xL: a case study with Bid

This study provides the structural model of the Bcl-xL/tBid complex at the mitochondrial membrane, revealing its dynamic architecture and mechanism of indirect apoptosis inhibition.

CD95/Fas Apoptosis Signal Initiation Depends on the Ligand Oligomerization State and Formation of Small Ligand-Receptor Complexes

This study investigates how CD95 ligand oligomerization and receptor-ligand stoichiometry influence apoptotic signaling, showing that trimeric ligands and bridging enhance receptor engagement and signaling potency.

MNT loss in MYC-driven B lymphoma cells enhances apoptosis, inhibits proliferation and increases sensitivity to cancer drugs.

This study shows that losing MNT in MYC-driven lymphoma cells increases apoptosis, reduces proliferation, and makes them more sensitive to cancer drugs.

PARP1 Suppression Drives ROS Resistance in Aneuploid Cancer Cells

This study shows that aneuploidy promotes ROS resistance by suppressing PARP1, which enhances metastasis, and identifies CEBPB as a key mediator of this process.

Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR

This paper reports the high-resolution structure of a viral:host hetero-amyloid complex between M45 and RIPK3, revealing its mechanism of inhibiting necroptosis.

Sanguinarine activates ATM/ATR-mediated CHK-1 signaling to drive p53-dependent apoptosis in the C. elegans germline

This study shows sanguinarine induces apoptosis in C. elegans germline via ROS-mediated activation of p53/CEP-1-dependent DNA damage pathways.

AlphaFold3-based modeling uncovers the dynamic structural interface between full-length IAP antagonists and DIAP1 for apoptosis regulation in Drosophila

The paper uses AlphaFold3 to model the 3D structures of IAP antagonists and DIAP1, revealing structural interactions and mechanisms of apoptosis regulation in Drosophila.

Inhibition of V-ATPase function drives apoptosis via GCN1/GCN2 kinase signaling

The paper identifies V-ATPase inhibition as a trigger for apoptosis via GCN1/GCN2 kinase signaling and MCL-1 depletion, revealing a therapeutic target in certain cancers.

Proximity labelling of the BAK macropore uncovers a new role for SLC35A4-MP in mitochondrial dynamics

This study uses proximity labeling to identify proteins near the BAK pore during apoptosis, revealing SLC35A4-MP's role in modulating mitochondrial dynamics.

Paclitaxel sensitizes TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-resistant breast cancer cells towards TRAIL-mediated apoptosis

This paper shows that paclitaxel sensitizes TRAIL-resistant breast cancer cells to TRAIL-induced apoptosis by altering TRAIL receptor expression.

A Mechanistic Model of Caspase-mediated Apoptosis Signaling Reveals Regulators of Drug Resistance in Prostate Cancer Cells

The paper develops a mechanistic model of caspase-mediated apoptosis in prostate cancer to identify regulators of drug resistance and predict therapeutic strategies.

A gated hydrophobic funnel within BAX binds long-chain alkenals to potentiate pro-apoptotic function

The paper identifies a hydrophobic funnel in BAX that binds 2t-hexadecenal, enhancing BAX activation with BIM, and shows proline 168 regulates this interaction.

Metacaspases mediate thermotolerance of diatoms following marine heat waves

This study shows that metacaspases in diatoms are crucial for thermotolerance during marine heat waves, as their absence leads to increased heat sensitivity and oxidative stress.

Systematic mutational mapping reveals optimal amyloid formation for RIPK function

This study maps mutations in RIPK1 and RIPK3 to reveal how amyloid formation is optimized for necroptosis, showing conserved mechanisms across species and evolutionary constraints.

Bcl-2 Oligomerizes Bax on the Mitochondrial Membrane Surface Preventing the Initial Stages of Apoptosis

This study shows Bcl-2 sequesters Bax into a complex on mitochondrial membranes, preventing pore formation and apoptosis initiation.

A live cell biosensor protocol for high-resolution screening of therapy-resistant cancer cells

This paper describes a protocol for using the GEDI biosensor to screen therapy-resistant cancer cells at single-cell resolution through time-resolved imaging and analysis.

Spatiotemporal dynamics of Mcl-1 abundance and its influence on apoptosis susceptibility

This study shows Mcl-1 accumulation and redistribution during the cell cycle increase MOMP thresholds, contributing to cell-to-cell variability in apoptosis susceptibility and intra-tumour heterogeneity.

The Second Mitochondrial Activator of Caspases (SMAC) regulates growth, inflammation and mitochondrial integrity in cancer cells

This study identifies SMAC as a regulator of cancer cell growth, inflammation, and mitochondrial integrity, showing its role in both apoptotic and non-apoptotic contexts.

The kinase domain of RIPK3 tunes its scaffolding functions

This study compares three RIPK3 kinase-dead variants to show that their scaffolding functions differ based on kinase domain conformation, not just kinase activity, and highlights implications for inhibitor development.

Hypoxia-inducible factor 1 protects neurons from Sarm1-mediated neurodegeneration

The paper identifies HIF-1 as a regulator of Sarm1-mediated neurodegeneration, showing that stabilized HIF-1 prevents NAD+ loss and protects neurons.