Cell death mechanisms and regulation

Mitochondria transported by Kinesin 3 prevent localized calcium spiking to inhibit caspase-dependent specialized cell death

The paper investigates the role of mitochondrial transport by kinesin motors in preventing localized calcium spiking and caspase-dependent cell death during specialized elimination in C. elegans neurons.

Integrated Multi-Optosis Model for Pan-Cancer Candidate Biomarker and Therapy Target Discovery

The paper develops a multi-optosis model integrating 25 RCD forms across 33 cancer types to discover candidate biomarkers and therapy targets using multi-omic and phenotypic data.

Pol II degradation activates cell death independently from the loss of transcription

The paper shows that loss of Pol II protein, specifically Rbp1, triggers apoptosis independently of transcriptional loss, revealing a new apoptotic response mechanism contributing to cancer therapy efficacy.

Arginyltransferase1 drives a mitochondria-dependent program to induce cell death

This study shows that Ate1 induces cell death via a mitochondria-dependent pathway, independent of cytosolic degradation pathways and mitochondrial ROS.

DFFB suppresses interferon to enable cancer persister cell regrowth

The paper identifies DFFB as a mechanism by which cancer persister cells suppress interferon to escape growth arrest and regrow after oncogene-targeted therapy.

Cul5Wsb2 uses BCL2 proteins as co-receptors to target Bim for degradation.

The paper identifies BCL2 proteins as co-receptors for CUL5WSB2 to target BIM for degradation, revealing a novel mechanism in apoptosis regulation with therapeutic implications for neuroblastomas and cancers.

The Role of c-Jun Signaling in Cytidine Analog-Induced Cell Death in Melanoma

This study investigates how melanoma cells respond to cytidine analogs like gemcitabine, showing that c-Jun signaling is involved in drug-induced cell death and cycle arrest.

High yield purification of an Isoleucine zipper modified CD95 Ligand with either biotin or DNA-oligomer binding domain for efficient Cell Apoptosis Induction

This paper describes the design and production of a stabilized CD95L variant with improved apoptosis induction efficiency and functionalization capabilities.

SNAI2 cooperates with MEK1/2 and HDACs to suppress BIM- and BMF-dependent apoptosis in TERT promoter mutant cancers

This study identifies that TPM cancers are vulnerable to MEK and HDAC inhibition, which synergize to enhance apoptosis via BIM and BMF pathways.

Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-XL degradation to overcome cancer chemoresistance

SARM1 base-exchange inhibitors induce SARM1 activation and neurodegeneration at low doses

This study shows that low doses of SARM1 base-exchange inhibitors paradoxically increase SARM1 activity and worsen neurodegeneration in vitro and in vivo.

A histidine switch regulates pH-dependent filament formation by the caspase-9 CARD

This study identifies a histidine switch in C9CARD that regulates pH-dependent filament formation through electrostatic interactions and structural changes.

Chlamydial membrane vesicles deliver the chlamydial porin OmpA to mitochondria to inhibit apoptosis

This study shows that Chlamydia trachomatis uses membrane vesicles to deliver OmpA to mitochondria, inhibiting apoptosis and promoting bacterial survival in human cells.

Multiplexed proximity labelling proteomics identifies a non-canonical Bcl-2 family interactome associated with apoptotic priming

The paper identifies a non-canonical Bcl-2 family interactome using proteomics, showing dynamic changes in response to apoptotic stimuli.

Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

The paper analyzes the evolutionary and functional roles of RIPK3 and its RHIM domain across vertebrates, finding that RHIM diversity tunes NF-κB activation while preserving cell death function.

Transgenic Bax gene efficiently induces lethality in mouse early embryos

This study compares the lethality-inducing potential of Bax, Casp3, and Casp9 in mouse early embryos and finds Bax most effective in causing embryo death.

Inhibition of TBK1/IKKe mediated RIPK1 phosphorylation sensitizes tumors to immune cell killing

This study shows that inhibiting TBK1/IKKe-mediated RIPK1 phosphorylation increases tumor sensitivity to immune cell killing by disrupting TNF signaling.

Integration of past caspase activity biases cell elimination in vivo

The paper shows that past sublethal caspase activity influences cell elimination decisions in Drosophila, revealing a new layer of apoptosis regulation.

Transcriptional Repression of reaper by Stand Still Safeguards Female Germline Development in Drosophila

This study identifies stand still as a regulator of apoptosis in Drosophila female germline cells, revealing two mechanisms that suppress reaper transcription and prevent cell death.

SARM1 is an essential component of neuronal Parthanatos

This study shows SARM1 is essential for neuronal Parthanatos, a cell death pathway triggered by DNA damage and linked to neurodegenerative diseases.

Mechanical forces drive mitochondrial matrix extrusion and apoptotic pore growth

The paper investigates the role of mechanical forces in mitochondrial inner membrane extrusion and apoptotic pore growth using CLOSE microscopy.

Harmonizing terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) with multiplexed iterative immunofluorescence enriches spatial contextualization of cell death

This paper harmonizes TUNEL with multiplexed immunofluorescence to improve spatial contextualization of cell death in tissues.

Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics

This study shows that ferroptosis and apoptosis can intersect, and BH3-mimetics can either enhance or suppress cell death depending on context.

The Discovery of Small Molecule Inhibitors of cFLIP that Sensitise Tumour Cells to TRAIL

This paper identifies small molecule inhibitors of cFLIP that enhance TRAIL-induced apoptosis in breast cancer cells and improves their potency through structure-activity relationship studies.

Functional Dissection of the Zdhhc5-GOLGA7 Protein Palmitoylation Complex

This study investigates the Zdhhc5-GOLGA7 protein complex involved in non-apoptotic cancer cell death induced by CIL56, revealing key residues critical for complex formation and cell death.

Cnidaria XIAP activates caspase-mediated cell death

This study investigates the function of XIAP in Cnidaria, showing it activates caspase-mediated cell death through BIR and RING domains, unlike its vertebrate counterpart.

Cathepsin X is a conserved cell death protein involved in algal response to environmental stress

The paper identifies cathepsin X as a conserved cell death protein in algae involved in responses to environmental stress through transcriptome analysis and mutant studies.

The tumour suppressor LACTB remodels mitochondria to promotecytochrome c release and apoptosis

This study identifies LACTB as a regulator of inner mitochondrial membrane dynamics during apoptosis, promoting cytochrome c release and apoptosis by remodeling cardiolipin-enriched membrane nanotubes.

Drug combinations with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids

The paper evaluates combinations of apoptosis pathway inhibitors with other agents in multi-cell type tumor spheroids to identify effective therapeutic strategies.

Epigenetic modulation of RIPK3 by Transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis

This study shows that Transglutaminase 2 (TG2) promotes necroptosis by serotonylating H3K4me3 at the Ripk3 promoter, preventing its methylation and enabling Ripk3 expression.